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      in Data Management & Statistics

      Summer research offers a springboard to advanced studies

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      Doctoral studies at MIT aren’t a calling for everyone, but they can be for anyone who has had opportunities to discover that science and technology research is their passion and to build the experience and skills to succeed. For Taylor Baum, Josefina Correa Menéndez, and Karla Alejandra Montejo, three graduate students in just one lab of The Picower Institute for Learning and Memory, a pivotal opportunity came via the MIT Summer Research Program in Biology and Neuroscience (MSRP-Bio). When a student finds MSRP-Bio, it helps them find their future in research. 

      In the program, undergraduate STEM majors from outside MIT spend the summer doing full-time research in the departments of Biology, Brain and Cognitive Sciences (BCS), or the Center for Brains, Minds and Machines (CBMM). They gain lab skills, mentoring, preparation for graduate school, and connections that might last a lifetime. Over the last two decades, a total of 215 students from underrepresented minority groups, who are from economically disadvantaged backgrounds, first-generation or nontraditional college students, or students with disabilities have participated in research in BCS or CBMM labs.  

      Like Baum, Correa Menéndez, and Montejo, the vast majority go on to pursue graduate studies, says Diversity and Outreach Coordinator Mandana Sassanfar, who runs the program. For instance, among 91 students who have worked in Picower Institute labs, 81 have completed their undergraduate studies. Of those, 46 enrolled in PhD programs at MIT or other schools such as Cornell, Yale, Stanford, and Princeton universities, and the University of California System. Another 12 have gone to medical school, another seven are in MD/PhD programs, and three have earned master’s degrees. The rest are studying as post-baccalaureates or went straight into the workforce after earning their bachelor’s degree. 

      After participating in the program, Baum, Correa Menéndez, and Montejo each became graduate students in the research group of Emery N. Brown, the Edward Hood Taplin Professor of Computational Neuroscience and Medical Engineering in The Picower Institute and the Institute for Medical Engineering and Science. The lab combines statistical, computational, and experimental neuroscience methods to study how general anesthesia affects the central nervous system to ultimately improve patient care and advance understanding of the brain. Brown says the students have each been doing “off-the-scale” work, in keeping with the excellence he’s seen from MSRP BIO students over the years. For example, on Aug. 10 Baum and Correa Menéndez were honored with MathWorks Fellowships.

      “I think MSRP is fantastic. Mandana does this amazing job of getting students who are quite talented to come to MIT to realize that they can move their game to the next level. They have the capacity to do it. They just need the opportunities,” Brown says. “These students live up to the expectations that you have of them. And now as graduate students, they’re taking on hard problems and they’re solving them.” 

      Paths to PhD studies 

      Pursuing a PhD is hardly a given. Many young students have never considered graduate school or specific fields of study like neuroscience or electrical engineering. But Sassanfar engages students across the country to introduce them to the opportunity MSRP-Bio provides to gain exposure, experience, and mentoring in advanced fields. Every fall, after the program’s students have returned to their undergraduate institutions, she visits schools in places as far flung as Florida, Maryland, Puerto Rico, and Texas and goes to conferences for diverse science communities such as ABRCMS and SACNAS to spread the word. 

      Taylor Baum

      Photo courtesy of Taylor Baum.

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      When Baum first connected with the program in 2017, she was finding her way at Penn State University. She had been majoring in biology and music composition but had just switched the latter to engineering following a conversation over coffee exposing her to brain-computer interfacing technology, in which detecting brain signals of people with full-body paralysis could improve their quality of life by enabling control of computers or wheelchairs. Baum became enthusiastic about the potential to build similar systems, but as a new engineering student, she struggled to find summer internships and research opportunities. 

      “I got rejected from every single progam except the MIT Center for Brains, Minds and Machines MSRP,” she recalls with a chuckle. 

      Baum thrived in MSRP-Bio, working in Brown’s lab for three successive summers. At each stage, she said, she gained more research skills, experience, and independence. When she graduated, she was sure she wanted to go to graduate school and applied to four of her dream schools. She accepted MIT’s offer to join the Department of Electrical Engineering and Computer Science, where she is co-advised by faculty members there and by Brown. She is now working to develop a system grounded in cardiovascular physiology that can improve blood pressure management. A tool for practicing anesthesiologists, the system automates the dosing of drugs to maintain a patient’s blood pressure at safe levels in the operating room or intensive care unit. 

      More than that, Baum not only is leading an organization advancing STEM education in Puerto Rico, but also is helping to mentor a current MSRP-Bio student in the Brown lab. 

      “MSRP definitely bonds everyone who has participated in it,” Baum says. “If I see anyone who I know participated in MSRP, we could have an immediate conversation. I know that most of us, if we needed help, we’d feel comfortable asking for help from someone from MSRP. With that shared experience, we have a sense of camaraderie, and community.” 

      In fact, a few years ago when a former MSRP-Bio student named Karla Montejo was applying to MIT, Baum provided essential advice and feedback about the application process, Montejo says. Now, as a graduate student, Montejo has become a mentor for the program in her own right, Sassanfar notes. For instance, Montejo serves on program alumni panels that advise new MSRP-Bio students. 

      Karla Alejandra Montejo

      Photo courtesy of Karla Alejandra Montejo.

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      Montejo’s family immigrated to Miami from Cuba when she was a child. The magnet high school she attended was so new that students were encouraged to help establish the school’s programs. She forged a path into research. 

      “I didn’t even know what research was,” she says. “I wanted to be a doctor, and I thought maybe it would help me on my resume. I thought it would be kind of like shadowing, but no, it was really different. So I got really captured by research when I was in high school.” 

      Despite continuing to pursue research in college at Florida International University, Montejo didn’t get into graduate school on her first attempt because she hadn’t yet learned how to focus her application. But Sassanfar had visited FIU to recruit students and through that relationship Montejo had already gone through MIT’s related Quantitative Methods Workshop (QMW). So Montejo enrolled in MSRP-Bio, working in the CBMM-affiliated lab of Gabriel Kreiman at Boston Children’s Hospital. 

      “I feel like Mandana really helped me out, gave me a break, and the MSRP experience pretty much solidified that I really wanted to come to MIT,” Montejo says. 

      In the QMW, Montejo learned she really liked computational neuroscience, and in Kreiman’s lab she got to try her hand at computational modeling of the cognition involved in making perceptual sense of complex scenes. Montejo realized she wanted to work on more biologically based neuroscience problems. When the summer ended, because she was off the normal graduate school cycle for now, she found a two-year post-baccalaurate program at Mayo Clinic studying the role a brain cell type called astrocytes might have in the Parkinson’s disease treatment deep brain stimulation. 

      When it came time to reapply to graduate schools (with the help of Baum and others in the BCS Application Assistance Program) Montejo applied to MIT and got in, joining the Brown lab. Now she’s working on modeling the role of  metabolic processes in the changing of brain rhythms under anesthesia, taking advantage of how general anesthesia predictably changes brain states. The effects anesthetic drugs have on cell metabolism and the way that ultimately affects levels of consciousness reveals important aspects of how metabolism affects brain circuits and systems. Earlier this month, for instance, Montejo co-led a paper the lab published in The Proceedings of the National Academy of Sciences detailing the neuroscience of a patient’s transition into an especially deep state of unconsciousness called “burst suppression.” 

      Josefina Correa Menendez

      Photo: David Orenstein

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      A signature of the Brown lab’s work is rigorous statistical analysis and methods, for instance to discern brain arousal states from EEG measures of brain rhythms. A PhD candidate in MIT’s Interdisciplinary Doctoral Program in Statistics, Correa Menéndez is advancing the use of Bayesian hierarchical models for neural data analysis. These statistical models offer a principled way of pooling information across datasets. One of her models can help scientists better understand the way neurons can “spike” with electrical activity when the brain is presented with a stimulus. The other’s power is in discerning critical features such as arousal states of the brain under general anesthesia from electrophysiological recordings. 

      Though she now works with complex equations and computations as a PhD candidate in neuroscience and statistics, Correa Menéndez was mostly interested in music art as a high school student at Academia María Reina in San Juan and then architecture in college at the University of Puerto Rico at Río Piedras. It was discussions at the intersection of epistemology and art during an art theory class that inspired Correa Menéndez to switch her major to biology and to take computer science classes, too. 

      When Sassanfar visited Puerto Rico in 2017, a computer science professor (Patricia Ordóñez) suggested that Correa Menéndez apply for a chance to attend the QMW. She did, and that led her to also participate in MSRP-Bio in the lab of Sherman Fairchild Professor Matt Wilson (a faculty member in BCS, CBMM, and the Picower Institute). She joined in the lab’s studies of how spatial memories are represented in the hippocampus and how the brain makes use of those memories to help understand the world around it. With mentoring from then-postdoc Carmen Varela (now a faculty member at Florida State University), the experience not only exposed her to neuroscience, but also helped her gain skills and experience with lab experiments, building research tools, and conducting statistical analyses. She ended up working in the Wilson lab as a research scholar for a year and began her graduate studies in September 2018.  

      Classes she took with Brown as a research scholar inspired her to join his lab as a graduate student. 

      “Taking the classes with Emery and also doing experiments made me aware of the role of statistics in the scientific process: from the interpretation of results to the analysis and the design of experiments,” she says. “More often than not, in science, statistics becomes this sort of afterthought — this ‘annoying’ thing that people need to do to get their paper published. But statistics as a field is actually a lot more than that. It’s a way of thinking about data. Particularly, Bayesian modeling provides a principled inference framework for combining prior knowledge into a hypothesis that you can test with data.” 

      To be sure, no one starts out with such inspiration about scientific scholarship, but MSRP-Bio helps students find that passion for research and the paths that opens up.   More

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      in Data Management & Statistics

      Embracing the future we need

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      When you picture MIT doctoral students taking small PhD courses together, you probably don’t imagine them going on class field trips. But it does happen, sometimes, and one of those trips changed Andy Sun’s career.

      Today, Sun is a faculty member at the MIT Sloan School of Management and a leading global expert on integrating renewable energy into the electric grid. Back in 2007, Sun was an operations research PhD candidate with a diversified academic background: He had studied electrical engineering, quantum computing, and analog computing but was still searching for a doctoral research subject involving energy. 

      One day, as part of a graduate energy class taught by visiting professor Ignacio J. Pérez Arriaga, the students visited the headquarters of ISO-New England, the organization that operates New England’s entire power grid and wholesale electricity market. Suddenly, it hit Sun. His understanding of engineering, used to design and optimize computing systems, could be applied to the grid as a whole, with all its connections, circuitry, and need for efficiency. 

      “The power grids in the U.S. continent are composed of two major interconnections, the Western Interconnection, the Eastern Interconnection, and one minor interconnection, the Texas grid,” Sun says. “Within each interconnection, the power grid is one big machine, essentially. It’s connected by tens of thousands of miles of transmission lines, thousands of generators, and consumers, and if anything is not synchronized, the system may collapse. It’s one of the most complicated engineering systems.”

      And just like that, Sun had a subject he was motivated to pursue. “That’s how I got into this field,” he says. “Taking a field trip.”Sun has barely looked back. He has published dozens of papers about optimizing the flow of intermittent renewable energy through the electricity grid, a major practical issue for grid operators, while also thinking broadly about the future form of the grid and the process of making almost all energy renewable. Sun, who in 2022 rejoined MIT as the Iberdrola-Avangrid Associate Professor in Electric Power Systems, and is also an associate professor of operations research, emphasizes the urgency of rapidly switching to renewables.

      “The decarbonization of our energy system is fundamental,” Sun says. “It will change a lot of things because it has to. We don’t have much time to get there. Two decades, three decades is the window in which we have to get a lot of things done. If you think about how much money will need to be invested, it’s not actually that much. We should embrace this future that we have to get to.”

      Successful operations

      Unexpected as it may have been, Sun’s journey toward being an electricity grid expert was informed by all the stages of his higher education. Sun grew up in China, and received his BA in electronic engineering from Tsinghua University in Beijing, in 2003. He then moved to MIT, joining the Media Lab as a graduate student. Sun intended to study quantum computing but instead began working on analog computer circuit design for Professor Neil Gershenfeld, another person whose worldview influenced Sun.  

      “He had this vision about how optimization is very important in things,” Sun says. “I had never heard of optimization before.” 

      To learn more about it, Sun started taking MIT courses in operations research. “I really enjoyed it, especially the nonlinear optimization course taught by Robert Freund in the Operations Research Center,” he recalls. 

      Sun enjoyed it so much that after a while, he joined MIT’s PhD program in operations research, thanks to the guidance of Freund. Later, he started working with MIT Sloan Professor Dimitri Bertsimas, a leading figure in the field. Still, Sun hadn’t quite nailed down what he wanted to focus on within operations research. Thinking of Sun’s engineering skills, Bertsimas suggested that Sun look for a research topic related to energy. 

      “He wasn’t an expert in energy at that time, but he knew that there are important problems there and encouraged me to go ahead and learn,” Sun says. 

      So it was that Sun found himself in ISO-New England headquarters one day in 2007, finally knowing what he wanted to study, and quickly finding opportunities to start learning from the organization’s experts on electricity markets. By 2011, Sun had finished his MIT PhD dissertation. Based in part on ISO-New England data, the thesis presented new modeling to more efficiently integrate renewable energy into the grid; built some new modeling tools grid operators could use; and developed a way to add fair short-term energy auctions to an efficient grid system.

      The core problem Sun deals with is that, unlike some other sources of electricity, renewables tend to be intermittent, generating power in an uneven pattern over time. That’s not an insurmountable problem for grid operators, but it does require some new approaches. Many of the papers Sun has written focus on precisely how to increasingly draw upon intermittent energy sources while ensuring that the grid’s current level of functionality remains intact. This is also the focus of his 2021 book, co-authored with Antonio J. Conejo, “Robust Optimiziation in Electric Energy Systems.”

      “A major theme of my research is how to achieve the integration of renewables and still operate the system reliably,” Sun says. “You have to keep the balance of supply and demand. This requires many time scales of operation from multidecade planning, to monthly or annual maintenance, to daily operations, down through second-by-second. I work on problems in all these timescales.”

      “I sit in the interface between power engineering and operations research,” Sun says. “I’m not a power engineer, but I sit in this boundary, and I keep the problems in optimization as my motivation.”

      Culture shift

      Sun’s presence on the MIT campus represents a homecoming of sorts. After receiving his doctorate from MIT, Sun spent a year as a postdoc at IBM’s Thomas J. Watson Research Center, then joined the faculty at Georgia Tech, where he remained for a decade. He returned to the Institute in January of 2022.

      “I’m just very excited about the opportunity of being back at MIT,” Sun says. “The MIT Energy Initiative is a such a vibrant place, where many people come together to work on energy. I sit in Sloan, but one very strong point of MIT is there are not many barriers, institutionally. I really look forward to working with colleagues from engineering, Sloan, everywhere, moving forward. We’re moving in the right direction, with a lot of people coming together to break the traditional academic boundaries.” 

      Still, Sun warns that some people may be underestimating the severity of the challenge ahead and the need to implement changes right now. The assets in power grids have long life time, lasting multiple decades. That means investment decisions made now could affect how much clean power is being used a generation from now. 

      “We’re talking about a short timeline, for changing something as huge as how a society fundamentally powers itself with energy,” Sun says. “A lot of that must come from the technology we have today. Renewables are becoming much better and cheaper, so their use has to go up.”

      And that means more people need to work on issues of how to deploy and integrate renewables into everyday life, in the electric grid, transportation, and more. Sun hopes people will increasingly recognize energy as a huge growth area for research and applied work. For instance, when MIT President Sally Kornbluth gave her inaugural address on May 1 this year, she emphasized tackling the climate crisis as her highest priority, something Sun noticed and applauded. 

      “I think the most important thing is the culture,” Sun says. “Bring climate up to the front, and create the platform to encourage people to come together and work on this issue.” More

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      in Data Management & Statistics

      The curse of variety in transportation systems

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      Cathy Wu has always delighted in systems that run smoothly. In high school, she designed a project to optimize the best route for getting to class on time. Her research interests and career track are evidence of a propensity for organizing and optimizing, coupled with a strong sense of responsibility to contribute to society instilled by her parents at a young age.

      As an undergraduate at MIT, Wu explored domains like agriculture, energy, and education, eventually homing in on transportation. “Transportation touches each of our lives,” she says. “Every day, we experience the inefficiencies and safety issues as well as the environmental harms associated with our transportation systems. I believe we can and should do better.”

      But doing so is complicated. Consider the long-standing issue of traffic systems control. Wu explains that it is not one problem, but more accurately a family of control problems impacted by variables like time of day, weather, and vehicle type — not to mention the types of sensing and communication technologies used to measure roadway information. Every differentiating factor introduces an exponentially larger set of control problems. There are thousands of control-problem variations and hundreds, if not thousands, of studies and papers dedicated to each problem. Wu refers to the sheer number of variations as the curse of variety — and it is hindering innovation.

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      “To prove that a new control strategy can be safely deployed on our streets can take years. As time lags, we lose opportunities to improve safety and equity while mitigating environmental impacts. Accelerating this process has huge potential,” says Wu.  

      Which is why she and her group in the MIT Laboratory for Information and Decision Systems are devising machine learning-based methods to solve not just a single control problem or a single optimization problem, but families of control and optimization problems at scale. “In our case, we’re examining emerging transportation problems that people have spent decades trying to solve with classical approaches. It seems to me that we need a different approach.”

      Optimizing intersections

      Currently, Wu’s largest research endeavor is called Project Greenwave. There are many sectors that directly contribute to climate change, but transportation is responsible for the largest share of greenhouse gas emissions — 29 percent, of which 81 percent is due to land transportation. And while much of the conversation around mitigating environmental impacts related to mobility is focused on electric vehicles (EVs), electrification has its drawbacks. EV fleet turnover is time-consuming (“on the order of decades,” says Wu), and limited global access to the technology presents a significant barrier to widespread adoption.

      Wu’s research, on the other hand, addresses traffic control problems by leveraging deep reinforcement learning. Specifically, she is looking at traffic intersections — and for good reason. In the United States alone, there are more than 300,000 signalized intersections where vehicles must stop or slow down before re-accelerating. And every re-acceleration burns fossil fuels and contributes to greenhouse gas emissions.

      Highlighting the magnitude of the issue, Wu says, “We have done preliminary analysis indicating that up to 15 percent of land transportation CO2 is wasted through energy spent idling and re-accelerating at intersections.”

      To date, she and her group have modeled 30,000 different intersections across 10 major metropolitan areas in the United States. That is 30,000 different configurations, roadway topologies (e.g., grade of road or elevation), different weather conditions, and variations in travel demand and fuel mix. Each intersection and its corresponding scenarios represents a unique multi-agent control problem.

      Wu and her team are devising techniques that can solve not just one, but a whole family of problems comprised of tens of thousands of scenarios. Put simply, the idea is to coordinate the timing of vehicles so they arrive at intersections when traffic lights are green, thereby eliminating the start, stop, re-accelerate conundrum. Along the way, they are building an ecosystem of tools, datasets, and methods to enable roadway interventions and impact assessments of strategies to significantly reduce carbon-intense urban driving.

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      Their collaborator on the project is the Utah Department of Transportation, which Wu says has played an essential role, in part by sharing data and practical knowledge that she and her group otherwise would not have been able to access publicly.

      “I appreciate industry and public sector collaborations,” says Wu. “When it comes to important societal problems, one really needs grounding with practitioners. One needs to be able to hear the perspectives in the field. My interactions with practitioners expand my horizons and help ground my research. You never know when you’ll hear the perspective that is the key to the solution, or perhaps the key to understanding the problem.”

      Finding the best routes

      In a similar vein, she and her research group are tackling large coordination problems. For example, vehicle routing. “Every day, delivery trucks route more than a hundred thousand packages for the city of Boston alone,” says Wu. Accomplishing the task requires, among other things, figuring out which trucks to use, which packages to deliver, and the order in which to deliver them as efficiently as possible. If and when the trucks are electrified, they will need to be charged, adding another wrinkle to the process and further complicating route optimization.

      The vehicle routing problem, and therefore the scope of Wu’s work, extends beyond truck routing for package delivery. Ride-hailing cars may need to pick up objects as well as drop them off; and what if delivery is done by bicycle or drone? In partnership with Amazon, for example, Wu and her team addressed routing and path planning for hundreds of robots (up to 800) in their warehouses.

      Every variation requires custom heuristics that are expensive and time-consuming to develop. Again, this is really a family of problems — each one complicated, time-consuming, and currently unsolved by classical techniques — and they are all variations of a central routing problem. The curse of variety meets operations and logistics.

      By combining classical approaches with modern deep-learning methods, Wu is looking for a way to automatically identify heuristics that can effectively solve all of these vehicle routing problems. So far, her approach has proved successful.

      “We’ve contributed hybrid learning approaches that take existing solution methods for small problems and incorporate them into our learning framework to scale and accelerate that existing solver for large problems. And we’re able to do this in a way that can automatically identify heuristics for specialized variations of the vehicle routing problem.” The next step, says Wu, is applying a similar approach to multi-agent robotics problems in automated warehouses.

      Wu and her group are making big strides, in part due to their dedication to use-inspired basic research. Rather than applying known methods or science to a problem, they develop new methods, new science, to address problems. The methods she and her team employ are necessitated by societal problems with practical implications. The inspiration for the approach? None other than Louis Pasteur, who described his research style in a now-famous article titled “Pasteur’s Quadrant.” Anthrax was decimating the sheep population, and Pasteur wanted to better understand why and what could be done about it. The tools of the time could not solve the problem, so he invented a new field, microbiology, not out of curiosity but out of necessity. More

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      in Data Management & Statistics

      Making sense of all things data

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      Data, and more specifically using data, is not a new concept, but it remains an elusive one. It comes with terms like “the internet of things” (IoT) and “the cloud,” and no matter how often those are explained, smart people can still be confused. And then there’s the amount of information available and the speed with which it comes in. Software is omnipresent. It’s in coffeemakers and watches, gathering data every second. The question becomes how to take all the new technology and take advantage of the potential insights and analytics. It’s not a small ask.

      “Putting our arms around what digital transformation is can be difficult to do,” says Abel Sanchez. But as the executive director and research director of MIT’s Geospatial Data Center, that’s exactly what he does with his work in helping industries and executives shift their operations in order to make sense of their data and be able to use it to help their bottom lines.

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      Handling the pace

      Data can lead to making better business decisions. That’s not a new or surprising insight, but as Sanchez says, people still tend to work off of intuition. Part of the problem is that they don’t know what to do with their available data, and there’s usually plenty of available data. Part of that problem is that there’s so much information being produced from so many sources. As soon as a person wakes up and turns on their phone or starts their car, software is running. It’s coming in fast, but because it’s also complex, “it outperforms people,” he says.

      As an example with Uber, once a person clicks on the app for a ride, predictive models start firing at the rate of 1 million per second. It’s all in order to optimize the trip, taking into account factors such as school schedules, roadway conditions, traffic, and a driver’s availability. It’s helpful for the task, but it’s something that “no human would be able to do,” he says. 

      The solution requires a few components. One is a new way to store data. In the past, the classic was creating the “perfect library,” which was too structured. The response to that was to create a “data lake,” where all the information would go in and somehow people would make sense of it. “This also failed,” Sanchez says.

      Data storage needs to be re-imaged, in which a key element is greater accessibility. In most corporations, only 10-20 percent of employees have the access and technical skill to work with the data. The rest have to go through a centralized resource and get into a queue, an inefficient system. The goal, Sanchez says, is to democratize the information by going to a modern stack, which would convert what he calls “dormant data” into “active data.” The result? Better decisions could be made.

      The first, big step companies need to take is the will to make the change. Part of it is an investment of money, but it’s also an attitude shift. Corporations can have an embedded culture where things have always been done a certain way and deviating from that is resisted because it’s different. But when it comes to data, a new approach is needed. Managing and curating the information can no longer rest in the hands of one person with the institutional memory. It’s not possible. It’s also not practical because companies are losing out on efficiency and productivity, because with technology, “What use to take years to do, now you can do in days,” Sanchez says.

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      The new player

      The above exemplifies what’s been involved with coordinating data along four intertwined components: IoT, AI, the cloud, and security. The first two create the information, which then gets stored in the cloud, but it’s all for naught without robust security. But one relative newcomer has come into the picture. It’s blockchain technology, a term that is often said but still not fully understood, adding further to the confusion.

      Sanchez says that information has been handled and organized a certain way with the World Wide Web. Blockchain is an opportunity to be more nimble and productive by offering the chance to have an accepted identity, currency, and logic that works on a global scale. The holdup has always been that there’s never been any agreement on those three components on a global scale. It leads to people being shut out, inefficiency, and lost business.

      One example, Sanchez says, of blockchain’s potential is with hospitals. In the United States, they’re private and information has to be constantly integrated from doctors, insurance companies, labs, government regulators, and pharmaceutical companies. It leads to repeated steps to do something as simple as recognizing a patient’s identity, which often can’t be agreed upon. With blockchain, these various entities can create a consortium using open source code with no barriers of access, and it could quickly and easily identify a patient because it set up an agreement, and with it “remove that level of effort.” It’s an incremental step, but one which can be built upon that reduces cost and risk.

      Another example — “one of the best examples,” Sanchez says — is what was done in Indonesia. Most of the rice, corn, and wheat that comes from this area is produced from smallholder farms. For the people making loans, it’s expensive to understand the risk of cultivating these plots of land. Compounding that is that these farmers don’t have state-issued identities or credit records, so, “They don’t exist in the modern economic sense,” he says. They don’t have access to loans, and banks are losing out on potential good customers.

      With this project, blockchain allowed local people to gather information about the farms on their smartphones. Banks could acquire the information and compensate the people with tokens, thereby incentivizing the work. The bank would see the creditworthiness of the farms, and farmers could end up getting fair loans.

      In the end, it creates a beneficial circle for the banks, farmers, and community, but it also represents what can be done with digital transformation by allowing businesses to optimize their processes, make better decisions, and ultimately profit.

      “It’s a tremendous new platform,” Sanchez says. “This is the promise.” More

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      in Data Management & Statistics

      Statistics, operations research, and better algorithms

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      In this day and age, many companies and institutions are not just data-driven, but data-intensive. Insurers, health providers, government agencies, and social media platforms are all heavily dependent on data-rich models and algorithms to identify the characteristics of the people who use them, and to nudge their behavior in various ways.

      That doesn’t mean organizations are always using optimal models, however. Determining efficient algorithms is a research area of its own — and one where Rahul Mazumder happens to be a leading expert.

      Mazumder, an associate professor in the MIT Sloan School of Management and an affiliate of the Operations Research Center, works both to expand the techniques of model-building and to refine models that apply to particular problems. His work pertains to a wealth of areas, including statistics and operations research, with applications in finance, health care, advertising, online recommendations, and more.

      “There is engineering involved, there is science involved, there is implementation involved, there is theory involved, it’s at the junction of various disciplines,” says Mazumder, who is also affiliated with the Center for Statistics and Data Science and the MIT-IBM Watson AI Lab.

      There is also a considerable amount of practical-minded judgment, logic, and common-sense decision-making at play, in order to bring the right techniques to bear on any individual task.

      “Statistics is about having data coming from a physical system, or computers, or humans, and you want to make sense of the data,” Mazumder says. “And you make sense of it by building models because that gives some pattern to a dataset. But of course, there is a lot of subjectivity in that. So, there is subjectivity in statistics, but also mathematical rigor.”

      Over roughly the last decade, Mazumder, often working with co-authors, has published about 40 peer-reviewed papers, won multiple academic awards, collaborated with major companies about their work, and helped advise graduate students. For his research and teaching, Mazumder was granted tenure by MIT last year.

      From deep roots to new tools

      Mazumder grew up in Kolkata, India, where his father was a professor at the Indian Statistical Institute and his mother was a schoolteacher. Mazumder received his undergraduate and master’s degrees from the Indian Statistical Institute as well, although without really focusing on the same areas as his father, whose work was in fluid mechanics.

      For his doctoral work, Mazumder attended Stanford University, where he earned his PhD in 2012. After a year as a postdoc at MIT’s Operations Research Center, he joined the faculty at Columbia University, then moved to MIT in 2015.

      While Mazumder’s work has many facets, his research portfolio does have notable central achievements. Mazumder has helped combine ideas from two branches of optimization to facilitate addressing computational problems in statistics. One of these branches, discrete optimization, uses discrete variables — integers — to find the best candidate among a finite set of options. This can relate to operational efficiency: What is the shortest route someone might take while making a designated set of stops? Convex optimization, on the other hand, encompasses an array of algorithms that can obtain the best solution for what Mazumder calls “nicely behaved” mathematical functions. They are typically applied to optimize continuous decisions in financial portfolio allocation and health care outcomes, among other things.

      In some recent papers, such as “Fast best subset selection: Coordinate descent and local combinatorial optimization algorithms,” co-authored with Hussein Hazimeh and published in Operations Research in 2020, and in “Sparse regression at scale: branch-and-bound rooted in first-order optimization,” co-authored with Hazimeh and A. Saab and published in Mathematical Programming in 2022, Mazumder has found ways to combine ideas from the two branches.

      “The tools and techniques we are using are new for the class of statistical problems because we are combining different developments in convex optimization and exploring that within discrete optimization,” Mazumder says.

      As new as these tools are, however, Mazumder likes working on techniques that “have old roots,” as he puts it. The two types of optimization methods were considered less separate in the 1950s or 1960s, he says, then grew apart.

      “I like to go back and see how things developed,” Mazumder says. “If I look back in history at [older] papers, it’s actually very fascinating. One thing was developed, another was developed, another was developed kind of independently, and after a while you see connections across them. If I go back, I see some parallels. And that actually helps in my thought process.”

      Predictions and parsimony

      Mazumder’s work is often aimed at simplifying the model or algorithm being applied to a problem. In some instances, bigger models would require enormous amounts of processing power, so simpler methods can provide equally good results while using fewer resources. In other cases — ranging from the finance and tech firms Mazumder has sometimes collaborated with — simpler models may work better by having fewer moving parts.

      “There is a notion of parsimony involved,” Mazumder says. Genomic studies aim to find particularly influential genes; similarly, tech giants may benefit from simpler models of consumer behavior, not more complex ones, when they are recommending a movie to you.

      Very often, Mazumder says, modeling “is a very large-scale prediction problem. But we don’t think all the features or attributes are going to be important. A small collection is going to be important. Why? Because if you think about movies, there are not really 20,000 different movies; there are genres of movies. If you look at individual users, there are hundreds of millions of users, but really they are grouped together into cliques. Can you capture the parsimony in a model?”

      One part of his career that does not lend itself to parsimony, Mazumder feels, is crediting others. In conversation he emphasizes how grateful he is to his mentors in academia, and how much of his work is developed in concert with collaborators and, in particular, his students at MIT. 

      “I really, really like working with my students,” Mazumder says. “I perceive my students as my colleagues. Some of these problems, I thought they could not be solved, but then we just made it work. Of course, no method is perfect. But the fact we can use ideas from different areas in optimization with very deep roots, to address problems of core statistics and machine learning interest, is very exciting.”

      Teaching and doing research at MIT, Mazumder says, allows him to push forward on difficult problems — while also being pushed along by the interest and work of others around him.

      “MIT is a very vibrant community,” Mazumder says. “The thing I find really fascinating is, people here are very driven. They want to make a change in whatever area they are working in. And I also feel motivated to do this.” More

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      Building a playbook for elite-level sports

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      “All I did was swim,” says Jerry Lu, recalling his teenage years as a competitive swimmer. “From age 12 to 19, it was close to 30 hours a week of training.” Although Lu no longer competes himself, his understanding of the dedication and impeccable technique required in elite sports continues to shape his path as a master’s student at the MIT Sloan School of Management.

      As an undergraduate at the University of Virginia, Lu majored in systems and information engineering and economics. He had stopped swimming competitively, but he stayed connected to the sport as a technical performance consultant for the university’s nationally ranked swim team. Under his advisor, Ken Ono, Lu built a methodology of analyzing data from sensors worn by swimmers to improve their individual performance. By looking at an athlete’s propulsion and drag data over the course of a race, Lu can advise them on where they can shave off tenths of a second simply by adjusting their stroke to be more efficient.

      That experience inspired Lu to pursue a career in other aspects of sports. At MIT he’s pursuing a master’s in finance to build the analytical skills necessary to enable the sustainability of sports that don’t already enjoy the major commercial success of, say, football or basketball. It’s especially a challenge for Olympic sports, such as swimming, which struggle for commercial ventures outside of Olympic years.

      “My work in swimming is focused on athlete performance to win, but the definition of winning is different for a sport as a whole, and for an organization,” Lu says. “Not only do you need to win medals, a big part of it is how you allocate money because you also need to grow your sport.”

      At MIT, Lu is building a playbook for high-performance sports from both an athletic and financial perspective. He’s been gaining exposure to additional elite sports by working with MIT’s Sports Lab under Professor Anette “Peko” Hosoi. His work there isn’t a requirement for his master’s program, but Lu appreciates that the program’s flexibility allows him time to pursue research that interests him, alongside the required curriculum.

      “I’m quite lucky to be here in the sense that MIT is known to train great people in engineering,  science, or business, but also people with unique passions,” says Lu. “People that love football drafting, people that love to understand how you throw a curveball — they use their knowledge in very unexpected ways, and that’s when innovation happens.”

      Lu’s research with the Sports Lab focuses on optimizing strategies for aesthetic sports, such as figure skating or snowboarding, which are judged very differently than swimming is. Instead of figuring out how to move faster, athletes are interested in structuring routines that net them the most points from a panel of judges. Modelling techniques can be helpful for figuring out how to put together routines to maximize an athlete’s abilities, and also to predict how a judge might assign points based on how or when a skill is demonstrated. Optimizing both athletic performance and judge psychology is a challenge, it’s this type of innovation that excites him. He hopes more sporting organizations will adopt similar data-driven strategies in the future.

      When asked where he’d like to end up after finishing his degree, “The sport industry is the natural choice,” Lu says. Though he is certain his career will lead to sports eventually, he is still open to exploring new paths. This summer he will be a trading intern at Citadel Securities to apply the concepts learned in his degree program courses. He’s also picked up sailing since coming to MIT, already reaching the highest amateur rating in under a year. Lu consistently strives for excellence, whether in himself or for those he works with.

      Since graduating from UVA, Lu has continued to work with swimmers, including national champions and Olympic medalists, as a technical performance consultant. He’s also branched out into another Olympic sport, triathlon. Lu describes it as a side gig, but he’s deeply invested in the athletes he works with, even taking trips to the Olympic Training Center to collect data and help them build strategies for improvement.

      “The most fun part is actually interacting with the athletes and engaging and understanding how they think,” says Lu. “It’s easier for me to do so than others, because if you’ve never swam before and you’ve never trained as an elite athlete before, it’s hard to understand what exactly you can and cannot do and how to communicate these things to a coach or an athlete.” More

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      Using data to write songs for progress

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      A three-year recipient of MIT’s Emerson Classical Vocal Scholarships, senior Ananya Gurumurthy recalls getting ready to step onto the Carnegie Hall stage to sing a Mozart opera that she once sang with the New York All-State Choir. The choir conductor reminded her to articulate her words and to engage her diaphragm.

      “If you don’t project your voice, how are people going to hear you when you perform?” Gurumurthy recalls her conductor telling her. “This is your moment, your chance to connect with such a tremendous audience.”

      Gurumurthy reflects on the universal truth of those words as she adds her musical talents to her math and computer science studies to campaign for social and economic justice.

      The daughter of immigrants

      Growing up in Edgemont, New York, she was inspired to fight on behalf of others by her South Asian immigrant parents, who came to the United States in the 1980s. Her father is a management consultant and her mother has experience as an investment banker.

      “They came barely 15 years after the passage of the 1965 Immigration and Nationality Act, which removed national origin quotas from the American immigration system,” she says. “I would not be here if it had not been for the Civil Rights Movement, which preceded both me and my parents.”

      Her parents told her about their new home’s anti-immigrant sentiments; for example, her father was a graduate student in Dallas exiting a store when he was pelted with glass bottles and racial slurs.

      “I often consider the amount of bravery that it must have taken them to abandon everything they knew to immigrate to a new, but still imperfect, country in search of something better,” she says. “As a result, I have always felt so grounded in my identity both as a South Asian American and a woman of color. These identities have allowed me to think critically about how I can most effectively reform the institutions surrounding me.”

      Gurumurthy has been singing since she was 11, but in high school, she decided to also build her political voice by working for New York Senator Andrea Stewart-Cousins. At one point, Gurumurthy noted a log was kept for the subjects of constituent calls, such as “affordable housing” and  “infrastructure,” and it was then that she became aware that Stewart-Cousins would address the most pressing of these callers’ issues before the Senate.

      “This experience was my first time witnessing how powerful the mobilization of constituents in vast numbers was for influencing meaningful legislative change,” says Gurumurthy.

      After she began applying her math skills to political campaigns, Gurumurthy was soon tapped to run analytics for the Democratic National Committee’s (DNC) midterm election initiative. As a lead analyst for the New York DNC, she adapted an interactive activation-competition (IAC) model to understand voting patterns in the 2018 and 2020 elections. She collected data from public voting records to predict how constituents would cast their ballots and used an IAC algorithm to strategize alongside grassroots organizations and allocate resources to empower historically disenfranchised groups in municipal, state, and federal elections to encourage them to vote.

      Research and student organizing at MIT

      When she arrived at MIT in 2019 to study mathematics with computer science, along with minors in music and economics, she admits she was saddled with the naïve notion that she would “build digital tools that could single-handedly alleviate all of the collective pressures of systemic injustice in this country.” 

      Since then, she has learned to create what she calls “a more nuanced view.” She picked up data analytics skills to build mobilization platforms for organizations that pursued social and economic justice, including working in Fulton County, Georgia, with Fair Fight Action (through the Kelly-Douglas Fund Scholarship) to analyze patterns of voter suppression, and MIT’s ethics laboratories in the Computer Science and Artificial Intelligence Laboratory to build symbolic artificial intelligence protocols to better understand bias in artificial intelligence algorithms. For her work on the International Monetary Fund (through the MIT Washington Summer Internship Program), Gurumurthy was awarded second place for the 2022 S. Klein Prize in Technical Writing for her paper “The Rapid Rise of Cryptocurrency.”

      “The outcomes of each project gave me more hope to begin the next because I could see the impact of these digital tools,” she says. “I saw people feel empowered to use their voices whether it was voting for the first time, protesting exploitative global monetary policy, or fighting gender discrimination. I’ve been really fortunate to see the power of mathematical analysis firsthand.”

      “I have come to realize that the constructive use of technology could be a powerful voice of resistance against injustice,” she says. “Because numbers matter, and when people bear witness to them, they are pushed to take action in meaningful ways.”

      Hoping to make a difference in her own community, she joined several Institute committees. As co-chair of the Undergraduate Association’s education committee, she propelled MIT’s first-ever digital petition for grade transparency and worked with faculty members on Institute committees to ensure that all students were being provided adequate resources to participate in online education in the wake of the Covid-19 pandemic. The digital petition inspired her to begin a project, called Insite, to develop a more centralized digital means of data collection on student life at MIT to better inform policies made by its governing bodies. As Ring Committee chair, she ensured that the special traditions of the “Brass Rat” were made economically accessible to all class members by helping the committee nearly triple its financial aid budget. For her efforts at MIT, last May she received the William L. Stewart, Jr. Award for “[her] contributions [as] an individual student at MIT to extracurricular activities and student life.”

      Ananya plans on going to law school after graduation, to study constitutional law so that she can use her technical background to build quantitative evidence in cases pertaining to voting rights, social welfare, and ethical technology, and set legal standards ”for the humane use of data,” she says.

      “In building digital tools for a variety of social and economic justice organizations, I hope that we can challenge our existing systems of power and realize the progress we so dearly need to witness. There is strength in numbers, both algorithmically and organizationally. I believe it is our responsibility to simultaneously use these strengths to change the world.”

      Her ambitions, however, began when she began singing lessons when she was 11; without her background as a vocalist, she says she would be voiceless.

      “Operatic performance has given me the ability to truly step into my character and convey powerful emotions in my performance. In the process, I have realized that my voice is most powerful when it reflects my true convictions, whether I am performing or publicly speaking. I truly believe that this honesty has allowed me to become an effective community organizer. I’d like to believe that this voice is what compels those around me to act.”

      Private musical study is available for students through the Emerson/Harris Program, which offers merit-based financial awards to students of outstanding achievement on their instruments or voice in classical, jazz, or world music. The Emerson/Harris Program is funded by the late Cherry L. Emerson Jr. SM ’41, in response to an appeal from Associate Provost Ellen T. Harris (Class of 1949 professor emeritus of music). More

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      Joining the battle against health care bias

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      Medical researchers are awash in a tsunami of clinical data. But we need major changes in how we gather, share, and apply this data to bring its benefits to all, says Leo Anthony Celi, principal research scientist at the MIT Laboratory for Computational Physiology (LCP). 

      One key change is to make clinical data of all kinds openly available, with the proper privacy safeguards, says Celi, a practicing intensive care unit (ICU) physician at the Beth Israel Deaconess Medical Center (BIDMC) in Boston. Another key is to fully exploit these open data with multidisciplinary collaborations among clinicians, academic investigators, and industry. A third key is to focus on the varying needs of populations across every country, and to empower the experts there to drive advances in treatment, says Celi, who is also an associate professor at Harvard Medical School. 

      In all of this work, researchers must actively seek to overcome the perennial problem of bias in understanding and applying medical knowledge. This deeply damaging problem is only heightened with the massive onslaught of machine learning and other artificial intelligence technologies. “Computers will pick up all our unconscious, implicit biases when we make decisions,” Celi warns.

      Play video

      Sharing medical data 

      Founded by the LCP, the MIT Critical Data consortium builds communities across disciplines to leverage the data that are routinely collected in the process of ICU care to understand health and disease better. “We connect people and align incentives,” Celi says. “In order to advance, hospitals need to work with universities, who need to work with industry partners, who need access to clinicians and data.” 

      The consortium’s flagship project is the MIMIC (medical information marked for intensive care) ICU database built at BIDMC. With about 35,000 users around the world, the MIMIC cohort is the most widely analyzed in critical care medicine. 

      International collaborations such as MIMIC highlight one of the biggest obstacles in health care: most clinical research is performed in rich countries, typically with most clinical trial participants being white males. “The findings of these trials are translated into treatment recommendations for every patient around the world,” says Celi. “We think that this is a major contributor to the sub-optimal outcomes that we see in the treatment of all sorts of diseases in Africa, in Asia, in Latin America.” 

      To fix this problem, “groups who are disproportionately burdened by disease should be setting the research agenda,” Celi says. 

      That’s the rule in the “datathons” (health hackathons) that MIT Critical Data has organized in more than two dozen countries, which apply the latest data science techniques to real-world health data. At the datathons, MIT students and faculty both learn from local experts and share their own skill sets. Many of these several-day events are sponsored by the MIT Industrial Liaison Program, the MIT International Science and Technology Initiatives program, or the MIT Sloan Latin America Office. 

      Datathons are typically held in that country’s national language or dialect, rather than English, with representation from academia, industry, government, and other stakeholders. Doctors, nurses, pharmacists, and social workers join up with computer science, engineering, and humanities students to brainstorm and analyze potential solutions. “They need each other’s expertise to fully leverage and discover and validate the knowledge that is encrypted in the data, and that will be translated into the way they deliver care,” says Celi. 

      “Everywhere we go, there is incredible talent that is completely capable of designing solutions to their health-care problems,” he emphasizes. The datathons aim to further empower the professionals and students in the host countries to drive medical research, innovation, and entrepreneurship.

      Play video

      Fighting built-in bias 

      Applying machine learning and other advanced data science techniques to medical data reveals that “bias exists in the data in unimaginable ways” in every type of health product, Celi says. Often this bias is rooted in the clinical trials required to approve medical devices and therapies. 

      One dramatic example comes from pulse oximeters, which provide readouts on oxygen levels in a patient’s blood. It turns out that these devices overestimate oxygen levels for people of color. “We have been under-treating individuals of color because the nurses and the doctors have been falsely assured that their patients have adequate oxygenation,” he says. “We think that we have harmed, if not killed, a lot of individuals in the past, especially during Covid, as a result of a technology that was not designed with inclusive test subjects.” 

      Such dangers only increase as the universe of medical data expands. “The data that we have available now for research is maybe two or three levels of magnitude more than what we had even 10 years ago,” Celi says. MIMIC, for example, now includes terabytes of X-ray, echocardiogram, and electrocardiogram data, all linked with related health records. Such enormous sets of data allow investigators to detect health patterns that were previously invisible. 

      “But there is a caveat,” Celi says. “It is trivial for computers to learn sensitive attributes that are not very obvious to human experts.” In a study released last year, for instance, he and his colleagues showed that algorithms can tell if a chest X-ray image belongs to a white patient or person of color, even without looking at any other clinical data. 

      “More concerningly, groups including ours have demonstrated that computers can learn easily if you’re rich or poor, just from your imaging alone,” Celi says. “We were able to train a computer to predict if you are on Medicaid, or if you have private insurance, if you feed them with chest X-rays without any abnormality. So again, computers are catching features that are not visible to the human eye.” And these features may lead algorithms to advise against therapies for people who are Black or poor, he says. 

      Opening up industry opportunities 

      Every stakeholder stands to benefit when pharmaceutical firms and other health-care corporations better understand societal needs and can target their treatments appropriately, Celi says. 

      “We need to bring to the table the vendors of electronic health records and the medical device manufacturers, as well as the pharmaceutical companies,” he explains. “They need to be more aware of the disparities in the way that they perform their research. They need to have more investigators representing underrepresented groups of people, to provide that lens to come up with better designs of health products.” 

      Corporations could benefit by sharing results from their clinical trials, and could immediately see these potential benefits by participating in datathons, Celi says. “They could really witness the magic that happens when that data is curated and analyzed by students and clinicians with different backgrounds from different countries. So we’re calling out our partners in the pharmaceutical industry to organize these events with us!”  More