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    AI model identifies certain breast tumor stages likely to progress to invasive cancer

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    Ductal carcinoma in situ (DCIS) is a type of preinvasive tumor that sometimes progresses to a highly deadly form of breast cancer. It accounts for about 25 percent of all breast cancer diagnoses.Because it is difficult for clinicians to determine the type and stage of DCIS, patients with DCIS are often overtreated. To address this, an interdisciplinary team of researchers from MIT and ETH Zurich developed an AI model that can identify the different stages of DCIS from a cheap and easy-to-obtain breast tissue image. Their model shows that both the state and arrangement of cells in a tissue sample are important for determining the stage of DCIS.Because such tissue images are so easy to obtain, the researchers were able to build one of the largest datasets of its kind, which they used to train and test their model. When they compared its predictions to conclusions of a pathologist, they found clear agreement in many instances.In the future, the model could be used as a tool to help clinicians streamline the diagnosis of simpler cases without the need for labor-intensive tests, giving them more time to evaluate cases where it is less clear if DCIS will become invasive.“We took the first step in understanding that we should be looking at the spatial organization of cells when diagnosing DCIS, and now we have developed a technique that is scalable. From here, we really need a prospective study. Working with a hospital and getting this all the way to the clinic will be an important step forward,” says Caroline Uhler, a professor in the Department of Electrical Engineering and Computer Science (EECS) and the Institute for Data, Systems, and Society (IDSS), who is also director of the Eric and Wendy Schmidt Center at the Broad Institute of MIT and Harvard and a researcher at MIT’s Laboratory for Information and Decision Systems (LIDS).Uhler, co-corresponding author of a paper on this research, is joined by lead author Xinyi Zhang, a graduate student in EECS and the Eric and Wendy Schmidt Center; co-corresponding author GV Shivashankar, professor of mechogenomics at ETH Zurich jointly with the Paul Scherrer Institute; and others at MIT, ETH Zurich, and the University of Palermo in Italy. The open-access research was published July 20 in Nature Communications.Combining imaging with AI   Between 30 and 50 percent of patients with DCIS develop a highly invasive stage of cancer, but researchers don’t know the biomarkers that could tell a clinician which tumors will progress.Researchers can use techniques like multiplexed staining or single-cell RNA sequencing to determine the stage of DCIS in tissue samples. However, these tests are too expensive to be performed widely, Shivashankar explains.In previous work, these researchers showed that a cheap imagining technique known as chromatin staining could be as informative as the much costlier single-cell RNA sequencing.For this research, they hypothesized that combining this single stain with a carefully designed machine-learning model could provide the same information about cancer stage as costlier techniques.First, they created a dataset containing 560 tissue sample images from 122 patients at three different stages of disease. They used this dataset to train an AI model that learns a representation of the state of each cell in a tissue sample image, which it uses to infer the stage of a patient’s cancer.However, not every cell is indicative of cancer, so the researchers had to aggregate them in a meaningful way.They designed the model to create clusters of cells in similar states, identifying eight states that are important markers of DCIS. Some cell states are more indicative of invasive cancer than others. The model determines the proportion of cells in each state in a tissue sample.Organization matters“But in cancer, the organization of cells also changes. We found that just having the proportions of cells in every state is not enough. You also need to understand how the cells are organized,” says Shivashankar.With this insight, they designed the model to consider proportion and arrangement of cell states, which significantly boosted its accuracy.“The interesting thing for us was seeing how much spatial organization matters. Previous studies had shown that cells which are close to the breast duct are important. But it is also important to consider which cells are close to which other cells,” says Zhang.When they compared the results of their model with samples evaluated by a pathologist, it had clear agreement in many instances. In cases that were not as clear-cut, the model could provide information about features in a tissue sample, like the organization of cells, that a pathologist could use in decision-making.This versatile model could also be adapted for use in other types of cancer, or even neurodegenerative conditions, which is one area the researchers are also currently exploring.“We have shown that, with the right AI techniques, this simple stain can be very powerful. There is still much more research to do, but we need to take the organization of cells into account in more of our studies,” Uhler says.This research was funded, in part, by the Eric and Wendy Schmidt Center at the Broad Institute, ETH Zurich, the Paul Scherrer Institute, the Swiss National Science Foundation, the U.S. National Institutes of Health, the U.S. Office of Naval Research, the MIT Jameel Clinic for Machine Learning and Health, the MIT-IBM Watson AI Lab, and a Simons Investigator Award. More

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      How to assess a general-purpose AI model’s reliability before it’s deployed

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      Foundation models are massive deep-learning models that have been pretrained on an enormous amount of general-purpose, unlabeled data. They can be applied to a variety of tasks, like generating images or answering customer questions.But these models, which serve as the backbone for powerful artificial intelligence tools like ChatGPT and DALL-E, can offer up incorrect or misleading information. In a safety-critical situation, such as a pedestrian approaching a self-driving car, these mistakes could have serious consequences.To help prevent such mistakes, researchers from MIT and the MIT-IBM Watson AI Lab developed a technique to estimate the reliability of foundation models before they are deployed to a specific task.They do this by considering a set of foundation models that are slightly different from one another. Then they use their algorithm to assess the consistency of the representations each model learns about the same test data point. If the representations are consistent, it means the model is reliable.When they compared their technique to state-of-the-art baseline methods, it was better at capturing the reliability of foundation models on a variety of downstream classification tasks.Someone could use this technique to decide if a model should be applied in a certain setting, without the need to test it on a real-world dataset. This could be especially useful when datasets may not be accessible due to privacy concerns, like in health care settings. In addition, the technique could be used to rank models based on reliability scores, enabling a user to select the best one for their task.“All models can be wrong, but models that know when they are wrong are more useful. The problem of quantifying uncertainty or reliability is more challenging for these foundation models because their abstract representations are difficult to compare. Our method allows one to quantify how reliable a representation model is for any given input data,” says senior author Navid Azizan, the Esther and Harold E. Edgerton Assistant Professor in the MIT Department of Mechanical Engineering and the Institute for Data, Systems, and Society (IDSS), and a member of the Laboratory for Information and Decision Systems (LIDS).He is joined on a paper about the work by lead author Young-Jin Park, a LIDS graduate student; Hao Wang, a research scientist at the MIT-IBM Watson AI Lab; and Shervin Ardeshir, a senior research scientist at Netflix. The paper will be presented at the Conference on Uncertainty in Artificial Intelligence.Measuring consensusTraditional machine-learning models are trained to perform a specific task. These models typically make a concrete prediction based on an input. For instance, the model might tell you whether a certain image contains a cat or a dog. In this case, assessing reliability could be a matter of looking at the final prediction to see if the model is right.But foundation models are different. The model is pretrained using general data, in a setting where its creators don’t know all downstream tasks it will be applied to. Users adapt it to their specific tasks after it has already been trained.Unlike traditional machine-learning models, foundation models don’t give concrete outputs like “cat” or “dog” labels. Instead, they generate an abstract representation based on an input data point.To assess the reliability of a foundation model, the researchers used an ensemble approach by training several models which share many properties but are slightly different from one another.“Our idea is like measuring the consensus. If all those foundation models are giving consistent representations for any data in our dataset, then we can say this model is reliable,” Park says.But they ran into a problem: How could they compare abstract representations?“These models just output a vector, comprised of some numbers, so we can’t compare them easily,” he adds.They solved this problem using an idea called neighborhood consistency.For their approach, the researchers prepare a set of reliable reference points to test on the ensemble of models. Then, for each model, they investigate the reference points located near that model’s representation of the test point.By looking at the consistency of neighboring points, they can estimate the reliability of the models.Aligning the representationsFoundation models map data points to what is known as a representation space. One way to think about this space is as a sphere. Each model maps similar data points to the same part of its sphere, so images of cats go in one place and images of dogs go in another.But each model would map animals differently in its own sphere, so while cats may be grouped near the South Pole of one sphere, another model could map cats somewhere in the Northern Hemisphere.The researchers use the neighboring points like anchors to align those spheres so they can make the representations comparable. If a data point’s neighbors are consistent across multiple representations, then one should be confident about the reliability of the model’s output for that point.When they tested this approach on a wide range of classification tasks, they found that it was much more consistent than baselines. Plus, it wasn’t tripped up by challenging test points that caused other methods to fail.Moreover, their approach can be used to assess reliability for any input data, so one could evaluate how well a model works for a particular type of individual, such as a patient with certain characteristics.“Even if the models all have average performance overall, from an individual point of view, you’d prefer the one that works best for that individual,” Wang says.However, one limitation comes from the fact that they must train an ensemble of foundation models, which is computationally expensive. In the future, they plan to find more efficient ways to build multiple models, perhaps by using small perturbations of a single model.“With the current trend of using foundational models for their embeddings to support various downstream tasks — from fine-tuning to retrieval augmented generation — the topic of quantifying uncertainty at the representation level is increasingly important, but challenging, as embeddings on their own have no grounding. What matters instead is how embeddings of different inputs are related to one another, an idea that this work neatly captures through the proposed neighborhood consistency score,” says Marco Pavone, an associate professor in the Department of Aeronautics and Astronautics at Stanford University, who was not involved with this work. “This is a promising step towards high quality uncertainty quantifications for embedding models, and I’m excited to see future extensions which can operate without requiring model-ensembling to really enable this approach to scale to foundation-size models.”This work is funded, in part, by the MIT-IBM Watson AI Lab, MathWorks, and Amazon. More

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      Machine learning and the microscope

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      With recent advances in imaging, genomics and other technologies, the life sciences are awash in data. If a biologist is studying cells taken from the brain tissue of Alzheimer’s patients, for example, there could be any number of characteristics they want to investigate — a cell’s type, the genes it’s expressing, its location within the tissue, or more. However, while cells can now be probed experimentally using different kinds of measurements simultaneously, when it comes to analyzing the data, scientists usually can only work with one type of measurement at a time.Working with “multimodal” data, as it’s called, requires new computational tools, which is where Xinyi Zhang comes in.The fourth-year MIT PhD student is bridging machine learning and biology to understand fundamental biological principles, especially in areas where conventional methods have hit limitations. Working in the lab of MIT Professor Caroline Uhler in the Department of Electrical Engineering and Computer Science, the Laboratory for Information and Decision Systems, and the Institute for Data, Systems, and Society, and collaborating with researchers at the Eric and Wendy Schmidt Center at the Broad Institute and elsewhere, Zhang has led multiple efforts to build computational frameworks and principles for understanding the regulatory mechanisms of cells.“All of these are small steps toward the end goal of trying to answer how cells work, how tissues and organs work, why they have disease, and why they can sometimes be cured and sometimes not,” Zhang says.The activities Zhang pursues in her down time are no less ambitious. The list of hobbies she has taken up at the Institute include sailing, skiing, ice skating, rock climbing, performing with MIT’s Concert Choir, and flying single-engine planes. (She earned her pilot’s license in November 2022.)“I guess I like to go to places I’ve never been and do things I haven’t done before,” she says with signature understatement.Uhler, her advisor, says that Zhang’s quiet humility leads to a surprise “in every conversation.”“Every time, you learn something like, ‘Okay, so now she’s learning to fly,’” Uhler says. “It’s just amazing. Anything she does, she does for the right reasons. She wants to be good at the things she cares about, which I think is really exciting.”Zhang first became interested in biology as a high school student in Hangzhou, China. She liked that her teachers couldn’t answer her questions in biology class, which led her to see it as the “most interesting” topic to study.Her interest in biology eventually turned into an interest in bioengineering. After her parents, who were middle school teachers, suggested studying in the United States, she majored in the latter alongside electrical engineering and computer science as an undergraduate at the University of California at Berkeley.Zhang was ready to dive straight into MIT’s EECS PhD program after graduating in 2020, but the Covid-19 pandemic delayed her first year. Despite that, in December 2022, she, Uhler, and two other co-authors published a paper in Nature Communications.The groundwork for the paper was laid by Xiao Wang, one of the co-authors. She had previously done work with the Broad Institute in developing a form of spatial cell analysis that combined multiple forms of cell imaging and gene expression for the same cell while also mapping out the cell’s place in the tissue sample it came from — something that had never been done before.This innovation had many potential applications, including enabling new ways of tracking the progression of various diseases, but there was no way to analyze all the multimodal data the method produced. In came Zhang, who became interested in designing a computational method that could.The team focused on chromatin staining as their imaging method of choice, which is relatively cheap but still reveals a great deal of information about cells. The next step was integrating the spatial analysis techniques developed by Wang, and to do that, Zhang began designing an autoencoder.Autoencoders are a type of neural network that typically encodes and shrinks large amounts of high-dimensional data, then expand the transformed data back to its original size. In this case, Zhang’s autoencoder did the reverse, taking the input data and making it higher-dimensional. This allowed them to combine data from different animals and remove technical variations that were not due to meaningful biological differences.In the paper, they used this technology, abbreviated as STACI, to identify how cells and tissues reveal the progression of Alzheimer’s disease when observed under a number of spatial and imaging techniques. The model can also be used to analyze any number of diseases, Zhang says.Given unlimited time and resources, her dream would be to build a fully complete model of human life. Unfortunately, both time and resources are limited. Her ambition isn’t, however, and she says she wants to keep applying her skills to solve the “most challenging questions that we don’t have the tools to answer.”She’s currently working on wrapping up a couple of projects, one focused on studying neurodegeneration by analyzing frontal cortex imaging and another on predicting protein images from protein sequences and chromatin imaging.“There are still many unanswered questions,” she says. “I want to pick questions that are biologically meaningful, that help us understand things we didn’t know before.” More

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      Community members receive 2024 MIT Excellence Awards, Collier Medal, and Staff Award for Distinction in Service

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      On Wednesday, June 5, 13 individuals and four teams were awarded MIT Excellence Awards — the highest awards for staff at the Institute. Colleagues holding signs, waving pompoms, and cheering gathered in Kresge Auditorium to show their support for the honorees. In addition to the Excellence Awards, staff members were honored with the Collier Medal, the Staff Award for Distinction in Service, and the Gordon Y. Billard Award. The Collier Medal honors the memory of Officer Sean Collier, who gave his life protecting and serving MIT; it celebrates an individual or group whose actions demonstrate the importance of community. The Staff Award for Distinction in Service is presented to a staff member whose service results in a positive lasting impact on the Institute.The Gordon Y. Billard Award is given annually to staff, faculty, or an MIT-affiliated individual(s) who has given “special service of outstanding merit performed for the Institute.” This year, for the first time, this award was presented at the MIT Excellence Awards and Collier Medal celebration. The 2024 MIT Excellence Award recipients and their award categories are: Innovative Solutions Nanotechnology Material Core Staff, Koch Institute for Integrative Cancer Research, Office of the Vice President for Research (Margaret Bisher, Giovanni de Nola, David Mankus, and Dong Soo Yun)Bringing Out the Best Salvatore Ieni James Kelsey Lauren PouchakServing Our Community Megan Chester Alessandra Davy-Falconi David Randall Days Weekend Team, Department of Custodial Services, Department of Facilities: Karen Melisa Betancourth, Ana Guerra Chavarria, Yeshi Khando, Joao Pacheco, and Kevin Salazar IMES/HST Academic Office Team, Institute for Medical Engineering and Science, School of Engineering: Traci Anderson, Joseph R. Stein, and Laurie Ward Team Leriche, Department of Custodial Services, Department of Facilities: Anthony Anzalone, David Solomon Carrasco, Larrenton Forrest, Michael Leriche, and Joe VieiraEmbracing Diversity, Equity, and Inclusion Bhaskar Pant Jessica TamOutstanding Contributor Paul W. Barone Marcia G. Davidson Steven Kooi Tianjiao Lei Andrew H. Mack

      2024 MIT Excellence Awards + Collier Medal Ceremony

      The 2024 Collier Medal recipient was Benjamin B. Lewis, a graduate student in the Institute for Data, Systems and Society in the MIT Schwarzman College of Computing. Last spring, he founded the Cambridge branch of End Overdose, a nonprofit dedicated to reducing drug-related overdose deaths. Through his efforts, more than 600 members of the Greater Boston community, including many at MIT, have been trained to administer lifesaving treatment at critical moments.This year’s recipient of the 2024 Staff Award for Distinction in Service was Diego F. Arango (Department of Custodial Services, Department of Facilities), daytime custodian in Building 46. He was nominated by no fewer than 36 staff, faculty, students, and researchers for creating a positive working environment and for offering “help whenever, wherever, and to whomever needs it.”Three community members were honored with a 2024 Gordon Y. Billard AwardDeborah G. Douglas, senior director of collections and curator of science and technology, MIT MuseumRonald Hasseltine, assistant provost for research administration, Office of the Vice President for ResearchRichard K. Lester, vice provost for international activities and Japan Steel Industry Professor of Nuclear Science and Engineering, School of EngineeringPresenters included President Sally Kornbluth; MIT Chief of Police John DiFava and Deputy Chief Steven DeMarco; Vice President for Human Resources Ramona Allen; Executive Vice President and Treasurer Glen Shor; Provost Cynthia Barnhart; Lincoln Laboratory director Eric Evans; Chancellor Melissa Nobles; and Dean of the School of Engineering Anantha Chandrakasan.Visit the MIT Human Resources website for more information about the award recipients, categories, and to view photos and video of the event. More

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      Study finds health risks in switching ships from diesel to ammonia fuel

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      As container ships the size of city blocks cross the oceans to deliver cargo, their huge diesel engines emit large quantities of air pollutants that drive climate change and have human health impacts. It has been estimated that maritime shipping accounts for almost 3 percent of global carbon dioxide emissions and the industry’s negative impacts on air quality cause about 100,000 premature deaths each year.Decarbonizing shipping to reduce these detrimental effects is a goal of the International Maritime Organization, a U.N. agency that regulates maritime transport. One potential solution is switching the global fleet from fossil fuels to sustainable fuels such as ammonia, which could be nearly carbon-free when considering its production and use.But in a new study, an interdisciplinary team of researchers from MIT and elsewhere caution that burning ammonia for maritime fuel could worsen air quality further and lead to devastating public health impacts, unless it is adopted alongside strengthened emissions regulations.Ammonia combustion generates nitrous oxide (N2O), a greenhouse gas that is about 300 times more potent than carbon dioxide. It also emits nitrogen in the form of nitrogen oxides (NO and NO2, referred to as NOx), and unburnt ammonia may slip out, which eventually forms fine particulate matter in the atmosphere. These tiny particles can be inhaled deep into the lungs, causing health problems like heart attacks, strokes, and asthma.The new study indicates that, under current legislation, switching the global fleet to ammonia fuel could cause up to about 600,000 additional premature deaths each year. However, with stronger regulations and cleaner engine technology, the switch could lead to about 66,000 fewer premature deaths than currently caused by maritime shipping emissions, with far less impact on global warming.“Not all climate solutions are created equal. There is almost always some price to pay. We have to take a more holistic approach and consider all the costs and benefits of different climate solutions, rather than just their potential to decarbonize,” says Anthony Wong, a postdoc in the MIT Center for Global Change Science and lead author of the study.His co-authors include Noelle Selin, an MIT professor in the Institute for Data, Systems, and Society and the Department of Earth, Atmospheric and Planetary Sciences (EAPS); Sebastian Eastham, a former principal research scientist who is now a senior lecturer at Imperial College London; Christine Mounaïm-Rouselle, a professor at the University of Orléans in France; Yiqi Zhang, a researcher at the Hong Kong University of Science and Technology; and Florian Allroggen, a research scientist in the MIT Department of Aeronautics and Astronautics. The research appears this week in Environmental Research Letters.Greener, cleaner ammoniaTraditionally, ammonia is made by stripping hydrogen from natural gas and then combining it with nitrogen at extremely high temperatures. This process is often associated with a large carbon footprint. The maritime shipping industry is betting on the development of “green ammonia,” which is produced by using renewable energy to make hydrogen via electrolysis and to generate heat.“In theory, if you are burning green ammonia in a ship engine, the carbon emissions are almost zero,” Wong says.But even the greenest ammonia generates nitrous oxide (N2O), nitrogen oxides (NOx) when combusted, and some of the ammonia may slip out, unburnt. This nitrous oxide would escape into the atmosphere, where the greenhouse gas would remain for more than 100 years. At the same time, the nitrogen emitted as NOx and ammonia would fall to Earth, damaging fragile ecosystems. As these emissions are digested by bacteria, additional N2O  is produced.NOx and ammonia also mix with gases in the air to form fine particulate matter. A primary contributor to air pollution, fine particulate matter kills an estimated 4 million people each year.“Saying that ammonia is a ‘clean’ fuel is a bit of an overstretch. Just because it is carbon-free doesn’t necessarily mean it is clean and good for public health,” Wong says.A multifaceted modelThe researchers wanted to paint the whole picture, capturing the environmental and public health impacts of switching the global fleet to ammonia fuel. To do so, they designed scenarios to measure how pollutant impacts change under certain technology and policy assumptions.From a technological point of view, they considered two ship engines. The first burns pure ammonia, which generates higher levels of unburnt ammonia but emits fewer nitrogen oxides. The second engine technology involves mixing ammonia with hydrogen to improve combustion and optimize the performance of a catalytic converter, which controls both nitrogen oxides and unburnt ammonia pollution.They also considered three policy scenarios: current regulations, which only limit NOx emissions in some parts of the world; a scenario that adds ammonia emission limits over North America and Western Europe; and a scenario that adds global limits on ammonia and NOx emissions.The researchers used a ship track model to calculate how pollutant emissions change under each scenario and then fed the results into an air quality model. The air quality model calculates the impact of ship emissions on particulate matter and ozone pollution. Finally, they estimated the effects on global public health.One of the biggest challenges came from a lack of real-world data, since no ammonia-powered ships are yet sailing the seas. Instead, the researchers relied on experimental ammonia combustion data from collaborators to build their model.“We had to come up with some clever ways to make that data useful and informative to both the technology and regulatory situations,” he says.A range of outcomesIn the end, they found that with no new regulations and ship engines that burn pure ammonia, switching the entire fleet would cause 681,000 additional premature deaths each year.“While a scenario with no new regulations is not very realistic, it serves as a good warning of how dangerous ammonia emissions could be. And unlike NOx, ammonia emissions from shipping are currently unregulated,” Wong says.However, even without new regulations, using cleaner engine technology would cut the number of premature deaths down to about 80,000, which is about 20,000 fewer than are currently attributed to maritime shipping emissions. With stronger global regulations and cleaner engine technology, the number of people killed by air pollution from shipping could be reduced by about 66,000.“The results of this study show the importance of developing policies alongside new technologies,” Selin says. “There is a potential for ammonia in shipping to be beneficial for both climate and air quality, but that requires that regulations be designed to address the entire range of potential impacts, including both climate and air quality.”Ammonia’s air quality impacts would not be felt uniformly across the globe, and addressing them fully would require coordinated strategies across very different contexts. Most premature deaths would occur in East Asia, since air quality regulations are less stringent in this region. Higher levels of existing air pollution cause the formation of more particulate matter from ammonia emissions. In addition, shipping volume over East Asia is far greater than elsewhere on Earth, compounding these negative effects.In the future, the researchers want to continue refining their analysis. They hope to use these findings as a starting point to urge the marine industry to share engine data they can use to better evaluate air quality and climate impacts. They also hope to inform policymakers about the importance and urgency of updating shipping emission regulations.This research was funded by the MIT Climate and Sustainability Consortium. More

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      A community collaboration for progress

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      While decades of discriminatory policies and practices continue to fuel the affordable housing crisis in the United States, less than three miles from the MIT campus exists a beacon of innovation and community empowerment.“We are very proud to continue MIT’s long-standing partnership with Camfield Estates,” says Catherine D’Ignazio, associate professor of urban science and planning. “Camfield has long been an incubator of creative ideas focused on uplifting their community.”D’Ignazio co-leads a research team focused on housing as part of the MIT Initiative for Combatting Systemic Racism (ICSR) led by the Institute for Data, Systems, and Society (IDSS). The group researches the uneven impacts of data, AI, and algorithmic systems on housing in the United States, as well as ways that these same tools could be used to address racial disparities. The Camfield Tenant Association is a research partner providing insight into the issue and relevant data, as well as opportunities for MIT researchers to solve real challenges and make a local impact.

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      MIT Initiative on Combatting Systemic Racism – Housing Video: MIT Sociotechnical Systems Research Center

      Formerly known as “Camfield Gardens,” the 102-unit housing development in Roxbury, Massachusetts, was among the pioneering sites in the 1990s to engage in the U.S. Department of Housing and Urban Development’s (HUD) program aimed at revitalizing disrepaired public housing across the country. This also served as the catalyst for their collaboration with MIT, which began in the early 2000s.“The program gave Camfield the money and energy to tear everything on the site down and build it back up anew, in addition to allowing them to buy the property from the city for $1 and take full ownership of the site,” explains Nolen Scruggs, a master’s student in the MIT Department of Urban Studies and Planning (DUSP) who has worked with Camfield over the past few years as part of ICSR’s housing vertical team. “At the time, MIT graduate students helped start a ‘digital divide’ bridge gap program that later evolved into the tech lab that is still there today, continuing to enable residents to learn computer skills and things they might need to get a hand up.”Because of that early collaboration, Camfield Estates reached out to MIT in 2022 to start a new chapter of collaboration with students. Scruggs spent a few months building a team of students from Harvard University, Wentworth Institute of Technology, and MIT to work on a housing design project meant to help the Camfield Tenants Association prepare for their looming redevelopment needs.“One of the things that’s been really important to the work of the ICSR housing vertical is historical context,” says Peko Hosoi, a professor of mechanical engineering and mathematics who co-leads the ICSR Housing vertical with D’Ignazio. “We didn’t get to the place we are right now with housing in an instant. There’s a lot of things that have happened in the U.S. like redlining, predatory lending, and different ways of investing in infrastructure that add important contexts.”“Quantitative methods are a great way to look across macroscale phenomena, but our team recognizes and values qualitative and participatory methods as well, to get a more grounded picture of what community needs really are and what kinds of innovations can bubble up from communities themselves,” D’Ignazio adds. “This is where the partnership with Camfield Estates comes in, which Nolen has been leading.”Finding creative solutionsBefore coming to MIT, Scruggs, a proud New Yorker, worked on housing issues while interning for his local congressperson, House Minority Leader Hakeem Jeffries. He called residents to discuss their housing concerns, learning about the affordability issues that were making it hard for lower- and middle-income families to find places to live.“Having this behind-the-scenes experience set the stage for my involvement in Camfield,” Scruggs says, recalling his start at Camfield conducting participatory action research, meeting with Camfield seniors to discuss and capture their concerns.Scruggs says the biggest issue they have been trying to tackle with Camfield is twofold: creating more space for new residents while also helping current residents achieve their end goal of homeownership.“This speaks to some of the larger issues our group at ICSR is working on in terms of housing affordability,” he says. “With Camfield it is looking at where can people with Section 8 vouchers move, what limits do they have, and what barriers do they face — whether it’s through big tech systems, or individual preferences coming from landlords.”Scruggs adds, “The discrimination those people face while trying to find a house, lock it down, talk to a bank, etc. — it can be very, very difficult and discouraging.” Scruggs says one attempt to combat this issue would be through hiring a caseworker to assist people through the process — one of many ideas that came from a Camfield collaboration with the FHLBank Affordable Housing Development Competition.As part of the competition, the goal for Scruggs’s team was to help Camfield tenants understand all of their options and their potential trade-offs, so that in the end they can make informed decisions about what they want to do with their space.“So often redevelopment schemes don’t ensure people can come back.” Scruggs says. “There are specific design proposals being made to ensure that the structure of people’s lifestyles wouldn’t be disrupted.”Scruggs says that tentative recommendations discussed with tenant association president Paulette Ford include replacing the community center with a high-rise development that would increase the number of units available.“I think they are thinking really creatively about their options,” Hosoi says. “Paulette Ford, and her mother before her, have always referred to Camfield as a ‘hand up,’ with the idea that people come to Camfield to live until they can afford a home of their own locally.”Scruggs’s other partnership with Camfield involves working with MIT undergraduate Amelie Nagle as part of the Undergraduate Research Opportunities Program to create programing that will teach computer design and coding to Camfield community kids — in the very TechLab that goes back to MIT and Camfield’s first collaboration.“Nolen has a real commitment to community-led knowledge production,” says D’Ignazio. “It has been a pleasure to work with him and see how he takes all his urban planning skills (GIS, mapping, urban design, photography, and more) to work in respectful ways that foreground community innovation.”She adds: “We are hopeful that the process will yield some high-quality architectural and planning ideas, and help Camfield take the next step towards realizing their innovative vision.” More

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      Janabel Xia: Algorithms, dance rhythms, and the drive to succeed

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      Senior math major Janabel Xia is a study of a person in constant motion.When she isn’t sorting algorithms and improving traffic control systems for driverless vehicles, she’s dancing as a member of at least four dance clubs. She’s joined several social justice organizations, worked on cryptography and web authentication technology, and created a polling app that allows users to vote anonymously.In her final semester, she’s putting the pedal to the metal, with a green light to lessen the carbon footprint of urban transportation by using sensors at traffic light intersections.First stepsGrowing up in Lexington, Massachusetts, Janabel has been competing on math teams since elementary school. On her math team, which met early mornings before the start of school, she discovered a love of problem-solving that challenged her more than her classroom “plug-and-chug exercises.”At Lexington High School, she was math team captain, a two-time Math Olympiad attendee, and a silver medalist for Team USA at the European Girls’ Mathematical Olympiad.As a math major, she studies combinatorics and theoretical computer science, including theoretical and applied cryptography. In her sophomore year, she was a researcher in the Cryptography and Information Security Group at the MIT Computer Science and Artificial Intelligence Laboratory, where she conducted cryptanalysis research under Professor Vinod Vaikuntanathan.Part of her interests in cryptography stem from the beauty of the underlying mathematics itself — the field feels like clever engineering with mathematical tools. But another part of her interest in cryptography stems from its political dimensions, including its potential to fundamentally change existing power structures and governance. Xia and students at the University of California at Berkeley and Stanford University created zkPoll, a private polling app written with the Circom programming language, that allows users to create polls for specific sets of people, while generating a zero-knowledge proof that keeps personal information hidden to decrease negative voting influences from public perception.Her participation in the PKG Center’s Active Community Engagement Freshman Pre-Orientation Program introduced her to local community organizations focusing on food security, housing for formerly incarcerated individuals, and access to health care. She is also part of Reading for Revolution, a student book club that discusses race, class, and working-class movements within MIT and the Greater Boston area.Xia’s educational journey led to her ongoing pursuit of combining mathematical and computational methods in areas adjacent to urban planning.  “When I realized how much planning was concerned with social justice as it was concerned with design, I became more attracted to the field.”Going on autopilotShe took classes with the Department of Urban Studies and Planning and is currently working on an Undergraduate Research Opportunities Program (UROP) project with Professor Cathy Wu in the Institute for Data, Systems, and Society.Recent work on eco-driving by Wu and doctoral student Vindula Jayawardana investigated semi-autonomous vehicles that communicate with sensors localized at traffic intersections, which in theory could reduce carbon emissions by up to 21 percent.Xia aims to optimize the implementation scheme for these sensors at traffic intersections, considering a graded scheme where perhaps only 20 percent of all sensors are initially installed, and more sensors get added in waves. She wants to maximize the emission reduction rates at each step of the process, as well as ensure there is no unnecessary installation and de-installation of such sensors.  Dance numbersMeanwhile, Xia has been a member of MIT’s Fixation, Ridonkulous, and MissBehavior groups, and as a traditional Chinese dance choreographer for the MIT Asian Dance Team. A dancer since she was 3, Xia started with Chinese traditional dance, and later added ballet and jazz. Because she is as much of a dancer as a researcher, she has figured out how to make her schedule work.“Production weeks are always madness, with dancers running straight from class to dress rehearsals and shows all evening and coming back early next morning to take down lights and roll up marley [material that covers the stage floor],” she says. “As busy as it keeps me, I couldn’t have survived MIT without dance. I love the discipline, creativity, and most importantly the teamwork that dance demands of us. I really love the dance community here with my whole heart. These friends have inspired me and given me the love to power me through MIT.”Xia lives with her fellow Dance Team members at the off-campus Women’s Independent Living Group (WILG).  “I really value WILG’s culture of independence, both in lifestyle — cooking, cleaning up after yourself, managing house facilities, etc. — and thought — questioning norms, staying away from status games, finding new passions.”In addition to her UROP, she’s wrapping up some graduation requirements, finishing up a research paper on sorting algorithms from her summer at the University of Minnesota Duluth Research Experience for Undergraduates in combinatorics, and deciding between PhD programs in math and computer science.  “My biggest goal right now is to figure out how to combine my interests in mathematics and urban studies, and more broadly connect technical perspectives with human-centered work in a way that feels right to me,” she says.“Overall, MIT has given me so many avenues to explore that I would have never thought about before coming here, for which I’m infinitely grateful. Every time I find something new, it’s hard for me not to find it cool. There’s just so much out there to learn about. While it can feel overwhelming at times, I hope to continue that learning and exploration for the rest of my life.” More

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      Q&A: Exploring ethnic dynamics and climate change in Africa

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      Evan Lieberman is the Total Professor of Political Science and Contemporary Africa at MIT, and is also director of the Center for International Studies. During a semester-long sabbatical, he’s currently based at the African Climate and Development Initiative at the University of Cape Town.In this Q&A, Lieberman discusses several climate-related research projects he’s pursuing in South Africa and surrounding countries. This is part of an ongoing series exploring how the School of Humanities, Arts, and Social Sciences is addressing the climate crisis.Q: South Africa is a nation whose political and economic development you have long studied and written about. Do you see this visit as an extension of the kind of research you have been pursuing, or a departure from it?A: Much of my previous work has been animated by the question of understanding the causes and consequences of group-based disparities, whether due to AIDS or Covid. These are problems that know no geographic boundaries, and where ethnic and racial minorities are often hardest hit. Climate change is an analogous problem, with these minority populations living in places where they are most vulnerable, in heat islands in cities, and in coastal areas where they are not protected. The reality is they might get hit much harder by longer-term trends and immediate shocks.In one line of research, I seek to understand how people in different African countries, in different ethnic groups, perceive the problems of climate change and their governments’ response to it. There are ethnic divisions of labor in terms of what people do — whether they are farmers or pastoralists, or live in cities. So some ethnic groups are simply more affected by drought or extreme weather than others, and this can be a basis for conflict, especially when competing for often limited government resources.In this area, just like in my previous research, learning what shapes ordinary citizen perspectives is really important, because these views affect people’s everyday practices, and the extent to which they support certain kinds of policies and investments their government makes in response to climate-related challenges. But I will also try to learn more about the perspectives of policymakers and various development partners who seek to balance climate-related challenges against a host of other problems and priorities.Q: You recently published “Until We Have Won Our Liberty,” which examines the difficult transition of South Africa from apartheid to a democratic government, scrutinizing in particular whether the quality of life for citizens has improved in terms of housing, employment, discrimination, and ethnic conflicts. How do climate change-linked issues fit into your scholarship?A: I never saw myself as a climate researcher, but a number of years ago, heavily influenced by what I was learning at MIT, I began to recognize more and more how important the issue of climate change is. And I realized there were lots of ways in which the climate problem resonated with other kinds of problems I had tackled in earlier parts of my work.There was once a time when climate and the environment was the purview primarily of white progressives: the “tree huggers.” And that’s really changed in recent decades as it has become evident that the people who’ve been most affected by the climate emergency are ethnic and racial minorities. We saw with Hurricane Katrina and other places [that] if you are Black, you’re more likely to live in a vulnerable area and to just generally experience more environmental harms, from pollution and emissions, leaving these communities much less resilient than white communities. Government has largely not addressed this inequity. When you look at American survey data in terms of who’s concerned about climate change, Black Americans, Hispanic Americans, and Asian Americans are more unified in their worries than are white Americans.There are analogous problems in Africa, my career research focus. Governments there have long responded in different ways to different ethnic groups. The research I am starting looks at the extent to which there are disparities in how governments try to solve climate-related challenges.Q: It’s difficult enough in the United States taking the measure of different groups’ perceptions of the impact of climate change and government’s effectiveness in contending with it. How do you go about this in Africa?A: Surprisingly, there’s only been a little bit of work done so far on how ordinary African citizens, who are ostensibly being hit the hardest in the world by the climate emergency, are thinking about this problem. Climate change has not been politicized there in a very big way. In fact, only 50 percent of Africans in one poll had heard of the term.In one of my new projects, with political science faculty colleague Devin Caughey and political science doctoral student Preston Johnston, we are analyzing social and climate survey data [generated by the Afrobarometer research network] from over 30 African countries to understand within and across countries the ways in which ethnic identities structure people’s perception of the climate crisis, and their beliefs in what government ought to be doing. In largely agricultural African societies, people routinely experience drought, extreme rain, and heat. They also lack the infrastructure that can shield them from the intense variability of weather patterns. But we’re adding a lens, which is looking at sources of inequality, especially ethnic differences.I will also be investigating specific sectors. Africa is a continent where in most places people cannot take for granted universal, piped access to clean water. In Cape Town, several years ago, the combination of failure to replace infrastructure and lack of rain caused such extreme conditions that one of the world’s most important cities almost ran out of water.While these studies are in progress, it is clear that in many countries, there are substantively large differences in perceptions of the severity of climate change, and attitudes about who should be doing what, and who’s capable of doing what. In several countries, both perceptions and policy preferences are differentiated along ethnic lines, more so than with respect to generational or class differences within societies.This is interesting as a phenomenon, but substantively, I think it’s important in that it may provide the basis for how politicians and government actors decide to move on allocating resources and implementing climate-protection policies. We see this kind of political calculation in the U.S. and we shouldn’t be surprised that it happens in Africa as well.That’s ultimately one of the challenges from the perch of MIT, where we’re really interested in understanding climate change, and creating technological tools and policies for mitigating the problem or adapting to it. The reality is frustrating. The political world — those who make decisions about whether to acknowledge the problem and whether to implement resources in the best technical way — are playing a whole other game. That game is about rewarding key supporters and being reelected.Q: So how do you go from measuring perceptions and beliefs among citizens about climate change and government responsiveness to those problems, to policies and actions that might actually reduce disparities in the way climate-vulnerable African groups receive support?A: Some of the work I have been doing involves understanding what local and national governments across Africa are actually doing to address these problems. We will have to drill down into government budgets to determine the actual resources devoted to addressing a challenge, what sorts of practices the government follows, and the political ramifications for governments that act aggressively versus those that don’t. With the Cape Town water crisis, for example, the government dramatically changed residents’ water usage through naming and shaming, and transformed institutional practices of water collection. They made it through a major drought by using much less water, and doing it with greater energy efficiency. Through the government’s strong policy and implementation, and citizens’ active responses, an entire city, with all its disparate groups, gained resilience. Maybe we can highlight creative solutions to major climate-related problems and use them as prods to push more effective policies and solutions in other places.In the MIT Global Diversity Lab, along with political science faculty colleague Volha Charnysh, political science doctoral student Jared Kalow, and Institute for Data, Systems and Society doctoral student Erin Walk, we are exploring American perspectives on climate-related foreign aid, asking survey respondents whether the U.S. should be giving more to people in the global South who didn’t cause the problems of climate change but have to suffer the externalities. We are particularly interested in whether people’s desire to help vulnerable communities rests on the racial or national identity of those communities.From my new seat as director of the Center for International Studies (CIS), I hope to do more and more to connect social science findings to relevant policymakers, whether in the U.S. or in other places. CIS is making climate one of our thematic priority areas, directing hundreds of thousands of dollars for MIT faculty to spark climate collaborations with researchers worldwide through the Global Seed Fund program. COP 28 (the U.N. Climate Change Conference), which I attended in December in Dubai, really drove home the importance of people coming together from around the world to exchange ideas and form networks. It was unbelievably large, with 85,000 people. But so many of us shared the belief that we are not doing enough. We need enforceable global solutions and innovation. We need ways of financing. We need to provide opportunities for journalists to broadcast the importance of this problem. And we need to understand the incentives that different actors have and what sorts of messages and strategies will resonate with them, and inspire those who have resources to be more generous. More

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      Growing our donated organ supply

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      For those in need of one, an organ transplant is a matter of life and death. 

      Every year, the medical procedure gives thousands of people with advanced or end-stage diseases extended life. This “second chance” is heavily dependent on the availability, compatibility, and proximity of a precious resource that can’t be simply bought, grown, or manufactured — at least not yet.

      Instead, organs must be given — cut from one body and implanted into another. And because living organ donation is only viable in certain cases, many organs are only available for donation after the donor’s death.

      Unsurprisingly, the logistical and ethical complexity of distributing a limited number of transplant organs to a growing wait list of patients has received much attention. There’s an important part of the process that has received less focus, however, and which may hold significant untapped potential: organ procurement itself.

      “If you have a donated organ, who should you give it to? This question has been extensively studied in operations research, economics, and even applied computer science,” says Hammaad Adam, a graduate student in the Social and Engineering Systems (SES) doctoral program at the MIT Institute for Data, Systems, and Society (IDSS). “But there’s been a lot less research on where that organ comes from in the first place.”

      In the United States, nonprofits called organ procurement organizations, or OPOs, are responsible for finding and evaluating potential donors, interacting with grieving families and hospital administrations, and recovering and delivering organs — all while following the federal laws that serve as both their mandate and guardrails. Recent studies estimate that obstacles and inefficiencies lead to thousands of organs going uncollected every year, even as the demand for transplants continues to grow.

      “There’s been little transparent data on organ procurement,” argues Adam. Working with MIT computer science professors Marzyeh Ghassemi and Ashia Wilson, and in collaboration with stakeholders in organ procurement, Adam led a project to create a dataset called ORCHID: Organ Retrieval and Collection of Health Information for Donation. ORCHID contains a decade of clinical, financial, and administrative data from six OPOs.

      “Our goal is for the ORCHID database to have an impact in how organ procurement is understood, internally and externally,” says Ghassemi.

      Efficiency and equity 

      It was looking to make an impact that drew Adam to SES and MIT. With a background in applied math and experience in strategy consulting, solving problems with technical components sits right in his wheelhouse.

      “I really missed challenging technical problems from a statistics and machine learning standpoint,” he says of his time in consulting. “So I went back and got a master’s in data science, and over the course of my master’s got involved in a bunch of academic research projects in a few different fields, including biology, management science, and public policy. What I enjoyed most were some of the more social science-focused projects that had immediate impact.”

      As a grad student in SES, Adam’s research focuses on using statistical tools to uncover health-care inequities, and developing machine learning approaches to address them. “Part of my dissertation research focuses on building tools that can improve equity in clinical trials and other randomized experiments,” he explains.

      One recent example of Adam’s work: developing a novel method to stop clinical trials early if the treatment has an unintended harmful effect for a minority group of participants. “I’ve also been thinking about ways to increase minority representation in clinical trials through improved patient recruitment,” he adds.

      Racial inequities in health care extend into organ transplantation, where a majority of wait-listed patients are not white — far in excess of their demographic groups’ proportion to the overall population. There are fewer organ donations from many of these communities, due to various obstacles in need of better understanding if they are to be overcome. 

      “My work in organ transplantation began on the allocation side,” explains Adam. “In work under review, we examined the role of race in the acceptance of heart, liver, and lung transplant offers by physicians on behalf of their patients. We found that Black race of the patient was associated with significantly lower odds of organ offer acceptance — in other words, transplant doctors seemed more likely to turn down organs offered to Black patients. This trend may have multiple explanations, but it is nevertheless concerning.”

      Adam’s research has also found that donor-candidate race match was associated with significantly higher odds of offer acceptance, an association that Adam says “highlights the importance of organ donation from racial minority communities, and has motivated our work on equitable organ procurement.”

      Working with Ghassemi through the IDSS Initiative on Combatting Systemic Racism, Adam was introduced to OPO stakeholders looking to collaborate. “It’s this opportunity to impact not only health-care efficiency, but also health-care equity, that really got me interested in this research,” says Adam.

      Play video

      MIT Initiative on Combatting Systemic Racism – HealthcareVideo: IDSS

      Making an impact

      Creating a database like ORCHID means solving problems in multiple domains, from the technical to the political. Some efforts never overcome the first step: getting data in the first place. Thankfully, several OPOs were already seeking collaborations and looking to improve their performance.

      “We have been lucky to have a strong partnership with the OPOs, and we hope to work together to find important insights to improve efficiency and equity,” says Ghassemi.

      The value of a database like ORCHID is in its potential for generating new insights, especially through quantitative analysis with statistics and computing tools like machine learning. The potential value in ORCHID was recognized with an MIT Prize for Open Data, an MIT Libraries award highlighting the importance and impact of research data that is openly shared.

      “It’s nice that the work got some recognition,” says Adam of the prize. “And it was cool to see some of the other great open data work that’s happening at MIT. I think there’s real impact in releasing publicly available data in an important and understudied domain.”

      All the same, Adam knows that building the database is only the first step.

      “I’m very interested in understanding the bottlenecks in the organ procurement process,” he explains. “As part of my thesis research, I’m exploring this by modeling OPO decision-making using causal inference and structural econometrics.”

      Using insights from this research, Adam also aims to evaluate policy changes that can improve both equity and efficiency in organ procurement. “And we’re hoping to recruit more OPOs, and increase the amount of data we’re releasing,” he says. “The dream state is every OPO joins our collaboration and provides updated data every year.”

      Adam is excited to see how other researchers might use the data to address inefficiencies in organ procurement. “Every organ donor saves between three and four lives,” he says. “So every research project that comes out of this dataset could make a real impact.” More