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    Creating new skills and new connections with MIT’s Quantitative Methods Workshop

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    Starting on New Year’s Day, when many people were still clinging to holiday revelry, scores of students and faculty members from about a dozen partner universities instead flipped open their laptops for MIT’s Quantitative Methods Workshop, a jam-packed, weeklong introduction to how computational and mathematical techniques can be applied to neuroscience and biology research. But don’t think of QMW as a “crash course.” Instead the program’s purpose is to help elevate each participant’s scientific outlook, both through the skills and concepts it imparts and the community it creates.

    “It broadens their horizons, it shows them significant applications they’ve never thought of, and introduces them to people whom as researchers they will come to know and perhaps collaborate with one day,” says Susan L. Epstein, a Hunter College computer science professor and education coordinator of MIT’s Center for Brains, Minds, and Machines, which hosts the program with the departments of Biology and Brain and Cognitive Sciences and The Picower Institute for Learning and Memory. “It is a model of interdisciplinary scholarship.”

    This year 83 undergraduates and faculty members from institutions that primarily serve groups underrepresented in STEM fields took part in the QMW, says organizer Mandana Sassanfar, senior lecturer and director of diversity and science outreach across the four hosting MIT entities. Since the workshop launched in 2010, it has engaged more than 1,000 participants, of whom more than 170 have gone on to participate in MIT Summer Research Programs (such as MSRP-BIO), and 39 have come to MIT for graduate school.

    Individual goals, shared experience

    Undergraduates and faculty in various STEM disciplines often come to QMW to gain an understanding of, or expand their expertise in, computational and mathematical data analysis. Computer science- and statistics-minded participants come to learn more about how such techniques can be applied in life sciences fields. In lectures; in hands-on labs where they used the computer programming language Python to process, analyze, and visualize data; and in less formal settings such as tours and lunches with MIT faculty, participants worked and learned together, and informed each other’s perspectives.

    Brain and Cognitive Sciences Professor Nancy Kanwisher delivers a lecture in MIT’s Building 46 on functional brain imaging to QMW participants.

    Photo: Mandana Sassanfar

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    And regardless of their field of study, participants made connections with each other and with the MIT students and faculty who taught and spoke over the course of the week.

    Hunter College computer science sophomore Vlad Vostrikov says that while he has already worked with machine learning and other programming concepts, he was interested to “branch out” by seeing how they are used to analyze scientific datasets. He also valued the chance to learn the experiences of the graduate students who teach QMW’s hands-on labs.

    “This was a good way to explore computational biology and neuroscience,” Vostrikov says. “I also really enjoy hearing from the people who teach us. It’s interesting to hear where they come from and what they are doing.”

    Jariatu Kargbo, a biology and chemistry sophomore at University of Maryland Baltimore County, says when she first learned of the QMW she wasn’t sure it was for her. It seemed very computation-focused. But her advisor Holly Willoughby encouraged Kargbo to attend to learn about how programming could be useful in future research — currently she is taking part in research on the retina at UMBC. More than that, Kargbo also realized it would be a good opportunity to make connections at MIT in advance of perhaps applying for MSRP this summer.

    “I thought this would be a great way to meet up with faculty and see what the environment is like here because I’ve never been to MIT before,” Kargbo says. “It’s always good to meet other people in your field and grow your network.”

    QMW is not just for students. It’s also for their professors, who said they can gain valuable professional education for their research and teaching.

    Fayuan Wen, an assistant professor of biology at Howard University, is no stranger to computational biology, having performed big data genetic analyses of sickle cell disease (SCD). But she’s mostly worked with the R programming language and QMW’s focus is on Python. As she looks ahead to projects in which she wants analyze genomic data to help predict disease outcomes in SCD and HIV, she says a QMW session delivered by biology graduate student Hannah Jacobs was perfectly on point.

    “This workshop has the skills I want to have,” Wen says.

    Moreover, Wen says she is looking to start a machine-learning class in the Howard biology department and was inspired by some of the teaching materials she encountered at QMW — for example, online curriculum modules developed by Taylor Baum, an MIT graduate student in electrical engineering and computer science and Picower Institute labs, and Paloma Sánchez-Jáuregui, a coordinator who works with Sassanfar.

    Tiziana Ligorio, a Hunter College computer science doctoral lecturer who together with Epstein teaches a deep machine-learning class at the City University of New York campus, felt similarly. Rather than require a bunch of prerequisites that might drive students away from the class, Ligorio was looking to QMW’s intense but introductory curriculum as a resource for designing a more inclusive way of getting students ready for the class.

    Instructive interactions

    Each day runs from 9 a.m. to 5 p.m., including morning and afternoon lectures and hands-on sessions. Class topics ranged from statistical data analysis and machine learning to brain-computer interfaces, brain imaging, signal processing of neural activity data, and cryogenic electron microscopy.

    “This workshop could not happen without dedicated instructors — grad students, postdocs, and faculty — who volunteer to give lectures, design and teach hands-on computer labs, and meet with students during the very first week of January,” Saassanfar says.

    MIT assistant professor of biology Brady Weissbourd (center) converses with QMW student participants during a lunch break.

    Photo: Mandana Sassanfar

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    The sessions surround student lunches with MIT faculty members. For example, at midday Jan. 2, assistant professor of biology Brady Weissbourd, an investigator in the Picower Institute, sat down with seven students in one of Building 46’s curved sofas to field questions about his neuroscience research in jellyfish and how he uses quantitative techniques as part of that work. He also described what it’s like to be a professor, and other topics that came to the students’ minds.

    Then the participants all crossed Vassar Street to Building 26’s Room 152, where they formed different but similarly sized groups for the hands-on lab “Machine learning applications to studying the brain,” taught by Baum. She guided the class through Python exercises she developed illustrating “supervised” and “unsupervised” forms of machine learning, including how the latter method can be used to discern what a person is seeing based on magnetic readings of brain activity.

    As students worked through the exercises, tablemates helped each other by supplementing Baum’s instruction. Ligorio, Vostrikov, and Kayla Blincow, assistant professor of biology at the University of the Virgin Islands, for instance, all leapt to their feet to help at their tables.

    Hunter College lecturer of computer science Tiziana Ligorio (standing) explains a Python programming concept to students at her table during a workshop session.

    Photo: David Orenstein

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    At the end of the class, when Baum asked students what they had learned, they offered a litany of new knowledge. Survey data that Sassanfar and Sánchez-Jáuregui use to anonymously track QMW outcomes, revealed many more such attestations of the value of the sessions. With a prompt asking how one might apply what they’ve learned, one respondent wrote: “Pursue a research career or endeavor in which I apply the concepts of computer science and neuroscience together.”

    Enduring connections

    While some new QMW attendees might only be able to speculate about how they’ll apply their new skills and relationships, Luis Miguel de Jesús Astacio could testify to how attending QMW as an undergraduate back in 2014 figured into a career where he is now a faculty member in physics at the University of Puerto Rico Rio Piedras Campus. After QMW, he returned to MIT that summer as a student in the lab of neuroscientist and Picower Professor Susumu Tonegawa. He came back again in 2016 to the lab of physicist and Francis Friedman Professor Mehran Kardar. What’s endured for the decade has been his connection to Sassanfar. So while he was once a student at QMW, this year he was back with a cohort of undergraduates as a faculty member.

    Michael Aldarondo-Jeffries, director of academic advancement programs at the University of Central Florida, seconded the value of the networking that takes place at QMW. He has brought students for a decade, including four this year. What he’s observed is that as students come together in settings like QMW or UCF’s McNair program, which helps to prepare students for graduate school, they become inspired about a potential future as researchers.

    “The thing that stands out is just the community that’s formed,” he says. “For many of the students, it’s the first time that they’re in a group that understands what they’re moving toward. They don’t have to explain why they’re excited to read papers on a Friday night.”

    Or why they are excited to spend a week including New Year’s Day at MIT learning how to apply quantitative methods to life sciences data. More

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      Making genetic prediction models more inclusive

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      While any two human genomes are about 99.9 percent identical, genetic variation in the remaining 0.1 percent plays an important role in shaping human diversity, including a person’s risk for developing certain diseases.

      Measuring the cumulative effect of these small genetic differences can provide an estimate of an individual’s genetic risk for a particular disease or their likelihood of having a particular trait. However, the majority of models used to generate these “polygenic scores” are based on studies done in people of European descent, and do not accurately gauge the risk for people of non-European ancestry or people whose genomes contain a mixture of chromosome regions inherited from previously isolated populations, also known as admixed ancestry.

      In an effort to make these genetic scores more inclusive, MIT researchers have created a new model that takes into account genetic information from people from a wider diversity of genetic ancestries across the world. Using this model, they showed that they could increase the accuracy of genetics-based predictions for a variety of traits, especially for people from populations that have been traditionally underrepresented in genetic studies.

      “For people of African ancestry, our model proved to be about 60 percent more accurate on average,” says Manolis Kellis, a professor of computer science in MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) and a member of the Broad Institute of MIT and Harvard. “For people of admixed genetic backgrounds more broadly, who have been excluded from most previous models, the accuracy of our model increased by an average of about 18 percent.”

      The researchers hope their more inclusive modeling approach could help improve health outcomes for a wider range of people and promote health equity by spreading the benefits of genomic sequencing more widely across the globe.

      “What we have done is created a method that allows you to be much more accurate for admixed and ancestry-diverse individuals, and ensure the results and the benefits of human genetics research are equally shared by everyone,” says MIT postdoc Yosuke Tanigawa, the lead and co-corresponding author of the paper, which appears today in open-access form in the American Journal of Human Genetics. The researchers have made all of their data publicly available for the broader scientific community to use.

      More inclusive models

      The work builds on the Human Genome Project, which mapped all of the genes found in the human genome, and on subsequent large-scale, cohort-based studies of how genetic variants in the human genome are linked to disease risk and other differences between individuals.

      These studies showed that the effect of any individual genetic variant on its own is typically very small. Together, these small effects add up and influence the risk of developing heart disease or diabetes, having a stroke, or being diagnosed with psychiatric disorders such as schizophrenia.

      “We have hundreds of thousands of genetic variants that are associated with complex traits, each of which is individually playing a weak effect, but together they are beginning to be predictive for disease predispositions,” Kellis says.

      However, most of these genome-wide association studies included few people of non-European descent, so polygenic risk models based on them translate poorly to non-European populations. People from different geographic areas can have different patterns of genetic variation, shaped by stochastic drift, population history, and environmental factors — for example, in people of African descent, genetic variants that protect against malaria are more common than in other populations. Those variants also affect other traits involving the immune system, such as counts of neutrophils, a type of immune cell. That variation would not be well-captured in a model based on genetic analysis of people of European ancestry alone.

      “If you are an individual of African descent, of Latin American descent, of Asian descent, then you are currently being left out by the system,” Kellis says. “This inequity in the utilization of genetic information for predicting risk of patients can cause unnecessary burden, unnecessary deaths, and unnecessary lack of prevention, and that’s where our work comes in.”

      Some researchers have begun trying to address these disparities by creating distinct models for people of European descent, of African descent, or of Asian descent. These emerging approaches assign individuals to distinct genetic ancestry groups, aggregate the data to create an association summary, and make genetic prediction models. However, these approaches still don’t represent people of admixed genetic backgrounds well.

      “Our approach builds on the previous work without requiring researchers to assign individuals or local genomic segments of individuals to predefined distinct genetic ancestry groups,” Tanigawa says. “Instead, we develop a single model for everybody by directly working on individuals across the continuum of their genetic ancestries.”

      In creating their new model, the MIT team used computational and statistical techniques that enabled them to study each individual’s unique genetic profile instead of grouping individuals by population. This methodological advancement allowed the researchers to include people of admixed ancestry, who made up nearly 10 percent of the UK Biobank dataset used for this study and currently account for about one in seven newborns in the United States.

      “Because we work at the individual level, there is no need for computing summary-level data for different populations,” Kellis says. “Thus, we did not need to exclude individuals of admixed ancestry, increasing our power by including more individuals and representing contributions from all populations in our combined model.”

      Better predictions

      To create their new model, the researchers used genetic data from more than 280,000 people, which was collected by UK Biobank, a large-scale biomedical database and research resource containing de-identified genetic, lifestyle, and health information from half a million U.K. participants. Using another set of about 81,000 held-out individuals from the UK Biobank, the researchers evaluated their model across 60 traits, which included traits related to body size and shape, such as height and body mass index, as well as blood traits such as white blood cell count and red blood cell count, which also have a genetic basis.

      The researchers found that, compared to models trained only on European-ancestry individuals, their model’s predictions are more accurate for all genetic ancestry groups. The most notable gain was for people of African ancestry, who showed 61 percent average improvements, even though they only made up about 1.5 percent of samples in UK Biobank. The researchers also saw improvements of 11 percent for people of South Asian descent and 5 percent for white British people. Predictions for people of admixed ancestry improved by about 18 percent.

      “When you bring all the individuals together in the training set, everybody contributes to the training of the polygenic score modeling on equal footing,” Tanigawa says. “Combined with increasingly more inclusive data collection efforts, our method can help leverage these efforts to improve predictive accuracy for all.”

      The MIT team hopes its approach can eventually be incorporated into tests of an individual’s risk of a variety of diseases. Such tests could be combined with conventional risk factors and used to help doctors diagnose disease or to help people manage their risk for certain diseases before they develop.

      “Our work highlights the power of diversity, equity, and inclusion efforts in the context of genomics research,” Tanigawa says.

      The researchers now hope to add even more data to their model, including data from the United States, and to apply it to additional traits that they didn’t analyze in this study.

      “This is just the start,” Kellis says. “We can’t wait to see more people join our effort to propel inclusive human genetics research.”

      The research was funded by the National Institutes of Health. More

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      Meet the 2023-24 Accenture Fellows

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      The MIT and Accenture Convergence Initiative for Industry and Technology has selected five new research fellows for 2023-24. Now in its third year, the initiative underscores the ways in which industry and research can collaborate to spur technological innovation.

      Through its partnership with the School of Engineering, Accenture provides five annual fellowships awarded to graduate students with the aim of generating powerful new insights on the convergence of business and technology with the potential to transform society. The 2023-24 fellows will conduct research in areas including artificial intelligence, sustainability, and robotics.

      The 2023-24 Accenture Fellows are:

      Yiyue Luo

      Yiyue Luo is a PhD candidate who is developing innovative integrations of tactile sensing and haptics, interactive sensing and AI, digital fabrication, and smart wearables. Her work takes advantage of recent advances in digital manufacturing and AI, and the convergence in advanced sensing and actuation mechanisms, scalable digital manufacturing, and emerging computational techniques, with the goal of creating novel sensing and actuation devices that revolutionize interactions between people and their environments. In past projects, Luo has developed tactile sensing apparel including socks, gloves, and vests, as well as a workflow for computationally designing and digitally fabricating soft textiles-based pneumatic actuators. With the support of an Accenture Fellowship, she will advance her work of combining sensing and actuating devices and explore the development of haptic devices that simulate tactile cues captured by tactile sensors. Her ultimate aim is to build a scalable, textile-based, closed-loop human-machine interface. Luo’s research holds exciting potential to advance ground-breaking applications for smart textiles, health care, artificial and virtual reality, human-machine interactions, and robotics.

      Zanele Munyikwa is a PhD candidate whose research explores foundation models, a class of models that forms the basis of transformative general-purpose technologies (GPTs) such as GPT4. An Accenture Fellowship will enable Munyikwa to conduct research aimed at illuminating the current and potential impact of foundation models (including large language models) on work and tasks common to “high-skilled” knowledge workers in industries such as marketing, legal services, and medicine, in which foundation models are expected to have significant economic and social impacts. A primary goal of her project is to observe the impact of AI augmentation on tasks like copywriting and long-form writing. A second aim is to explore two primary ways that foundation models are driving the convergence of creative and technological industries, namely: reducing the cost of content generation and enabling the development of tools and platforms for education and training. Munyikwa’s work has important implications for the use of foundation models in many fields, from health care and education to legal services, business, and technology.

      Michelle Vaccaro is a PhD candidate in social engineering systems whose research explores human-AI collaboration with the goals of developing a deeper understanding of AI-based technologies (including ChatGPT and DALL-E), evaluating their performance and evolution, and steering their development toward societally beneficial applications, like climate change mitigation. An Accenture Fellowship will support Vaccaro’s current work toward two key objectives: identifying synergies between humans and AI-based software to help design human-AI systems that address persistent problems better than existing approaches; and investigating applications of human-AI collaboration for forecasting technological change, specifically for renewable energy technologies. By integrating the historically distinct domains of AI, systems engineering, and cognitive science with a wide range of industries, technical fields, and social applications, Vaccaro’s work has the potential to advance individual and collective productivity and creativity in all these areas.

      Chonghuan Wang is a PhD candidate in computational science and engineering whose research employs statistical learning, econometrics theory, and experimental design to create efficient, reliable, and sustainable field experiments in various domains. In his current work, Wang is applying statistical learning techniques such as online learning and bandit theory to test the effectiveness of new treatments, vaccinations, and health care interventions. With the support of an Accenture Fellowship, he will design experiments with the specific aim of understanding the trade-off between the loss of a patient’s welfare and the accuracy of estimating the treatment effect. The results of this research could help to save lives and contain disease outbreaks during pandemics like Covid-19. The benefits of enhanced experiment design and the collection of high-quality data extend well beyond health care; for example, these tools could help businesses optimize user engagement, test pricing impacts, and increase the usage of platforms and services. Wang’s research holds exciting potential to harness statistical learning, econometrics theory, and experimental design in support of strong businesses and the greater social good.

      Aaron Michael West Jr. is a PhD candidate whose research seeks to enhance our knowledge of human motor control and robotics. His work aims to advance rehabilitation technologies and prosthetic devices, as well as improve robot dexterity. His previous work has yielded valuable insights into the human ability to extract information solely from visual displays. Specifically, he demonstrated humans’ ability to estimate stiffness based solely on the visual observation of motion. These insights could advance the development of software applications with the same capability (e.g., using machine learning methods applied to video data) and may enable roboticists to develop enhanced motion control such that a robot’s intention is perceivable by humans. An Accenture Fellowship will enable West to continue this work, as well as new investigations into the functionality of the human hand to aid in the design of a prosthetic hand that better replicates human dexterity. By advancing understandings of human bio- and neuro-mechanics, West’s work has the potential to support major advances in robotics and rehabilitation technologies, with profound impacts on human health and well-being. More

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      Summer research offers a springboard to advanced studies

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      Doctoral studies at MIT aren’t a calling for everyone, but they can be for anyone who has had opportunities to discover that science and technology research is their passion and to build the experience and skills to succeed. For Taylor Baum, Josefina Correa Menéndez, and Karla Alejandra Montejo, three graduate students in just one lab of The Picower Institute for Learning and Memory, a pivotal opportunity came via the MIT Summer Research Program in Biology and Neuroscience (MSRP-Bio). When a student finds MSRP-Bio, it helps them find their future in research. 

      In the program, undergraduate STEM majors from outside MIT spend the summer doing full-time research in the departments of Biology, Brain and Cognitive Sciences (BCS), or the Center for Brains, Minds and Machines (CBMM). They gain lab skills, mentoring, preparation for graduate school, and connections that might last a lifetime. Over the last two decades, a total of 215 students from underrepresented minority groups, who are from economically disadvantaged backgrounds, first-generation or nontraditional college students, or students with disabilities have participated in research in BCS or CBMM labs.  

      Like Baum, Correa Menéndez, and Montejo, the vast majority go on to pursue graduate studies, says Diversity and Outreach Coordinator Mandana Sassanfar, who runs the program. For instance, among 91 students who have worked in Picower Institute labs, 81 have completed their undergraduate studies. Of those, 46 enrolled in PhD programs at MIT or other schools such as Cornell, Yale, Stanford, and Princeton universities, and the University of California System. Another 12 have gone to medical school, another seven are in MD/PhD programs, and three have earned master’s degrees. The rest are studying as post-baccalaureates or went straight into the workforce after earning their bachelor’s degree. 

      After participating in the program, Baum, Correa Menéndez, and Montejo each became graduate students in the research group of Emery N. Brown, the Edward Hood Taplin Professor of Computational Neuroscience and Medical Engineering in The Picower Institute and the Institute for Medical Engineering and Science. The lab combines statistical, computational, and experimental neuroscience methods to study how general anesthesia affects the central nervous system to ultimately improve patient care and advance understanding of the brain. Brown says the students have each been doing “off-the-scale” work, in keeping with the excellence he’s seen from MSRP BIO students over the years. For example, on Aug. 10 Baum and Correa Menéndez were honored with MathWorks Fellowships.

      “I think MSRP is fantastic. Mandana does this amazing job of getting students who are quite talented to come to MIT to realize that they can move their game to the next level. They have the capacity to do it. They just need the opportunities,” Brown says. “These students live up to the expectations that you have of them. And now as graduate students, they’re taking on hard problems and they’re solving them.” 

      Paths to PhD studies 

      Pursuing a PhD is hardly a given. Many young students have never considered graduate school or specific fields of study like neuroscience or electrical engineering. But Sassanfar engages students across the country to introduce them to the opportunity MSRP-Bio provides to gain exposure, experience, and mentoring in advanced fields. Every fall, after the program’s students have returned to their undergraduate institutions, she visits schools in places as far flung as Florida, Maryland, Puerto Rico, and Texas and goes to conferences for diverse science communities such as ABRCMS and SACNAS to spread the word. 

      Taylor Baum

      Photo courtesy of Taylor Baum.

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      When Baum first connected with the program in 2017, she was finding her way at Penn State University. She had been majoring in biology and music composition but had just switched the latter to engineering following a conversation over coffee exposing her to brain-computer interfacing technology, in which detecting brain signals of people with full-body paralysis could improve their quality of life by enabling control of computers or wheelchairs. Baum became enthusiastic about the potential to build similar systems, but as a new engineering student, she struggled to find summer internships and research opportunities. 

      “I got rejected from every single progam except the MIT Center for Brains, Minds and Machines MSRP,” she recalls with a chuckle. 

      Baum thrived in MSRP-Bio, working in Brown’s lab for three successive summers. At each stage, she said, she gained more research skills, experience, and independence. When she graduated, she was sure she wanted to go to graduate school and applied to four of her dream schools. She accepted MIT’s offer to join the Department of Electrical Engineering and Computer Science, where she is co-advised by faculty members there and by Brown. She is now working to develop a system grounded in cardiovascular physiology that can improve blood pressure management. A tool for practicing anesthesiologists, the system automates the dosing of drugs to maintain a patient’s blood pressure at safe levels in the operating room or intensive care unit. 

      More than that, Baum not only is leading an organization advancing STEM education in Puerto Rico, but also is helping to mentor a current MSRP-Bio student in the Brown lab. 

      “MSRP definitely bonds everyone who has participated in it,” Baum says. “If I see anyone who I know participated in MSRP, we could have an immediate conversation. I know that most of us, if we needed help, we’d feel comfortable asking for help from someone from MSRP. With that shared experience, we have a sense of camaraderie, and community.” 

      In fact, a few years ago when a former MSRP-Bio student named Karla Montejo was applying to MIT, Baum provided essential advice and feedback about the application process, Montejo says. Now, as a graduate student, Montejo has become a mentor for the program in her own right, Sassanfar notes. For instance, Montejo serves on program alumni panels that advise new MSRP-Bio students. 

      Karla Alejandra Montejo

      Photo courtesy of Karla Alejandra Montejo.

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      Montejo’s family immigrated to Miami from Cuba when she was a child. The magnet high school she attended was so new that students were encouraged to help establish the school’s programs. She forged a path into research. 

      “I didn’t even know what research was,” she says. “I wanted to be a doctor, and I thought maybe it would help me on my resume. I thought it would be kind of like shadowing, but no, it was really different. So I got really captured by research when I was in high school.” 

      Despite continuing to pursue research in college at Florida International University, Montejo didn’t get into graduate school on her first attempt because she hadn’t yet learned how to focus her application. But Sassanfar had visited FIU to recruit students and through that relationship Montejo had already gone through MIT’s related Quantitative Methods Workshop (QMW). So Montejo enrolled in MSRP-Bio, working in the CBMM-affiliated lab of Gabriel Kreiman at Boston Children’s Hospital. 

      “I feel like Mandana really helped me out, gave me a break, and the MSRP experience pretty much solidified that I really wanted to come to MIT,” Montejo says. 

      In the QMW, Montejo learned she really liked computational neuroscience, and in Kreiman’s lab she got to try her hand at computational modeling of the cognition involved in making perceptual sense of complex scenes. Montejo realized she wanted to work on more biologically based neuroscience problems. When the summer ended, because she was off the normal graduate school cycle for now, she found a two-year post-baccalaurate program at Mayo Clinic studying the role a brain cell type called astrocytes might have in the Parkinson’s disease treatment deep brain stimulation. 

      When it came time to reapply to graduate schools (with the help of Baum and others in the BCS Application Assistance Program) Montejo applied to MIT and got in, joining the Brown lab. Now she’s working on modeling the role of  metabolic processes in the changing of brain rhythms under anesthesia, taking advantage of how general anesthesia predictably changes brain states. The effects anesthetic drugs have on cell metabolism and the way that ultimately affects levels of consciousness reveals important aspects of how metabolism affects brain circuits and systems. Earlier this month, for instance, Montejo co-led a paper the lab published in The Proceedings of the National Academy of Sciences detailing the neuroscience of a patient’s transition into an especially deep state of unconsciousness called “burst suppression.” 

      Josefina Correa Menendez

      Photo: David Orenstein

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      A signature of the Brown lab’s work is rigorous statistical analysis and methods, for instance to discern brain arousal states from EEG measures of brain rhythms. A PhD candidate in MIT’s Interdisciplinary Doctoral Program in Statistics, Correa Menéndez is advancing the use of Bayesian hierarchical models for neural data analysis. These statistical models offer a principled way of pooling information across datasets. One of her models can help scientists better understand the way neurons can “spike” with electrical activity when the brain is presented with a stimulus. The other’s power is in discerning critical features such as arousal states of the brain under general anesthesia from electrophysiological recordings. 

      Though she now works with complex equations and computations as a PhD candidate in neuroscience and statistics, Correa Menéndez was mostly interested in music art as a high school student at Academia María Reina in San Juan and then architecture in college at the University of Puerto Rico at Río Piedras. It was discussions at the intersection of epistemology and art during an art theory class that inspired Correa Menéndez to switch her major to biology and to take computer science classes, too. 

      When Sassanfar visited Puerto Rico in 2017, a computer science professor (Patricia Ordóñez) suggested that Correa Menéndez apply for a chance to attend the QMW. She did, and that led her to also participate in MSRP-Bio in the lab of Sherman Fairchild Professor Matt Wilson (a faculty member in BCS, CBMM, and the Picower Institute). She joined in the lab’s studies of how spatial memories are represented in the hippocampus and how the brain makes use of those memories to help understand the world around it. With mentoring from then-postdoc Carmen Varela (now a faculty member at Florida State University), the experience not only exposed her to neuroscience, but also helped her gain skills and experience with lab experiments, building research tools, and conducting statistical analyses. She ended up working in the Wilson lab as a research scholar for a year and began her graduate studies in September 2018.  

      Classes she took with Brown as a research scholar inspired her to join his lab as a graduate student. 

      “Taking the classes with Emery and also doing experiments made me aware of the role of statistics in the scientific process: from the interpretation of results to the analysis and the design of experiments,” she says. “More often than not, in science, statistics becomes this sort of afterthought — this ‘annoying’ thing that people need to do to get their paper published. But statistics as a field is actually a lot more than that. It’s a way of thinking about data. Particularly, Bayesian modeling provides a principled inference framework for combining prior knowledge into a hypothesis that you can test with data.” 

      To be sure, no one starts out with such inspiration about scientific scholarship, but MSRP-Bio helps students find that passion for research and the paths that opens up.   More

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      Statistics, operations research, and better algorithms

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      In this day and age, many companies and institutions are not just data-driven, but data-intensive. Insurers, health providers, government agencies, and social media platforms are all heavily dependent on data-rich models and algorithms to identify the characteristics of the people who use them, and to nudge their behavior in various ways.

      That doesn’t mean organizations are always using optimal models, however. Determining efficient algorithms is a research area of its own — and one where Rahul Mazumder happens to be a leading expert.

      Mazumder, an associate professor in the MIT Sloan School of Management and an affiliate of the Operations Research Center, works both to expand the techniques of model-building and to refine models that apply to particular problems. His work pertains to a wealth of areas, including statistics and operations research, with applications in finance, health care, advertising, online recommendations, and more.

      “There is engineering involved, there is science involved, there is implementation involved, there is theory involved, it’s at the junction of various disciplines,” says Mazumder, who is also affiliated with the Center for Statistics and Data Science and the MIT-IBM Watson AI Lab.

      There is also a considerable amount of practical-minded judgment, logic, and common-sense decision-making at play, in order to bring the right techniques to bear on any individual task.

      “Statistics is about having data coming from a physical system, or computers, or humans, and you want to make sense of the data,” Mazumder says. “And you make sense of it by building models because that gives some pattern to a dataset. But of course, there is a lot of subjectivity in that. So, there is subjectivity in statistics, but also mathematical rigor.”

      Over roughly the last decade, Mazumder, often working with co-authors, has published about 40 peer-reviewed papers, won multiple academic awards, collaborated with major companies about their work, and helped advise graduate students. For his research and teaching, Mazumder was granted tenure by MIT last year.

      From deep roots to new tools

      Mazumder grew up in Kolkata, India, where his father was a professor at the Indian Statistical Institute and his mother was a schoolteacher. Mazumder received his undergraduate and master’s degrees from the Indian Statistical Institute as well, although without really focusing on the same areas as his father, whose work was in fluid mechanics.

      For his doctoral work, Mazumder attended Stanford University, where he earned his PhD in 2012. After a year as a postdoc at MIT’s Operations Research Center, he joined the faculty at Columbia University, then moved to MIT in 2015.

      While Mazumder’s work has many facets, his research portfolio does have notable central achievements. Mazumder has helped combine ideas from two branches of optimization to facilitate addressing computational problems in statistics. One of these branches, discrete optimization, uses discrete variables — integers — to find the best candidate among a finite set of options. This can relate to operational efficiency: What is the shortest route someone might take while making a designated set of stops? Convex optimization, on the other hand, encompasses an array of algorithms that can obtain the best solution for what Mazumder calls “nicely behaved” mathematical functions. They are typically applied to optimize continuous decisions in financial portfolio allocation and health care outcomes, among other things.

      In some recent papers, such as “Fast best subset selection: Coordinate descent and local combinatorial optimization algorithms,” co-authored with Hussein Hazimeh and published in Operations Research in 2020, and in “Sparse regression at scale: branch-and-bound rooted in first-order optimization,” co-authored with Hazimeh and A. Saab and published in Mathematical Programming in 2022, Mazumder has found ways to combine ideas from the two branches.

      “The tools and techniques we are using are new for the class of statistical problems because we are combining different developments in convex optimization and exploring that within discrete optimization,” Mazumder says.

      As new as these tools are, however, Mazumder likes working on techniques that “have old roots,” as he puts it. The two types of optimization methods were considered less separate in the 1950s or 1960s, he says, then grew apart.

      “I like to go back and see how things developed,” Mazumder says. “If I look back in history at [older] papers, it’s actually very fascinating. One thing was developed, another was developed, another was developed kind of independently, and after a while you see connections across them. If I go back, I see some parallels. And that actually helps in my thought process.”

      Predictions and parsimony

      Mazumder’s work is often aimed at simplifying the model or algorithm being applied to a problem. In some instances, bigger models would require enormous amounts of processing power, so simpler methods can provide equally good results while using fewer resources. In other cases — ranging from the finance and tech firms Mazumder has sometimes collaborated with — simpler models may work better by having fewer moving parts.

      “There is a notion of parsimony involved,” Mazumder says. Genomic studies aim to find particularly influential genes; similarly, tech giants may benefit from simpler models of consumer behavior, not more complex ones, when they are recommending a movie to you.

      Very often, Mazumder says, modeling “is a very large-scale prediction problem. But we don’t think all the features or attributes are going to be important. A small collection is going to be important. Why? Because if you think about movies, there are not really 20,000 different movies; there are genres of movies. If you look at individual users, there are hundreds of millions of users, but really they are grouped together into cliques. Can you capture the parsimony in a model?”

      One part of his career that does not lend itself to parsimony, Mazumder feels, is crediting others. In conversation he emphasizes how grateful he is to his mentors in academia, and how much of his work is developed in concert with collaborators and, in particular, his students at MIT. 

      “I really, really like working with my students,” Mazumder says. “I perceive my students as my colleagues. Some of these problems, I thought they could not be solved, but then we just made it work. Of course, no method is perfect. But the fact we can use ideas from different areas in optimization with very deep roots, to address problems of core statistics and machine learning interest, is very exciting.”

      Teaching and doing research at MIT, Mazumder says, allows him to push forward on difficult problems — while also being pushed along by the interest and work of others around him.

      “MIT is a very vibrant community,” Mazumder says. “The thing I find really fascinating is, people here are very driven. They want to make a change in whatever area they are working in. And I also feel motivated to do this.” More

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      Celebrating the impact of IDSS

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      The “interdisciplinary approach” is something that has been lauded for decades for its ability to break down silos and create new integrated approaches to research.

      For Munther Dahleh, founding director of the MIT Institute for Data, Systems, and Society (IDSS), showing the community that data science and statistics can transcend individual disciplines and form a new holistic approach to addressing complex societal challenges has been crucial to the institute’s success.

      “From the very beginning, it was critical that we recognized the areas of data science, statistics, AI, and, in a way, computing, as transdisciplinary,” says Dahleh, who is the William A. Coolidge Professor in Electrical Engineering and Computer Science. “We made that point over and over — these are areas that embed in your field. It is not ours; this organization is here for everyone.”

      On April 14-15, researchers from across and beyond MIT joined together to celebrate the accomplishments and impact IDSS has had on research and education since its inception in 2015. Taking the place of IDSS’s annual statistics and data science conference SDSCon, the celebration also doubled as a way to recognize Dahleh for his work creating and executing the vision of IDSS as he prepares to step down from his director position this summer.

      In addition to talks and panels on statistics and computation, smart systems, automation and artificial intelligence, conference participants discussed issues ranging from climate change, health care, and misinformation. Nobel Prize winner and IDSS affiliate Professor Esther Duflo spoke on large scale immunization efforts, former MLK Visiting Professor Craig Watkins joined a panel on equity and justice in AI, and IDSS Associate Director Alberto Abadie discussed synthetic controls for policy evaluation. Other policy questions were explored through lightning talks, including those by students from the Technology and Policy Program (TPP) within IDSS.

      A place to call home

      The list of IDSS accomplishments over the last eight years is long and growing. From creating a home for 21st century statistics at MIT after other unsuccessful attempts, to creating a new PhD preparing the trilingual student who is an expert in data science and social science in the context of a domain, to playing a key role in determining an effective process for Covid testing in the early days of the pandemic, IDSS has left its mark on MIT. More recently, IDSS launched an initiative using big data to help effect structural and normative change toward racial equity, and will continue to explore societal challenges through the lenses of statistics, social science, and science and engineering.

      “I’m very proud of what we’ve done and of all the people who have contributed to this. The leadership team has been phenomenal in their commitment and their creativity,” Dahleh says. “I always say it doesn’t take one person, it takes the village to do what we have done, and I am very proud of that.”

      Prior to the institute’s formation, Dahleh and others at MIT were brought together to answer one key question: How would MIT prepare for the future of systems and data?

      “Data science is a complex area because in some ways it’s everywhere and it belongs to everyone, similar to statistics and AI,” Dahleh says “The most important part of creating an organization to support it was making it clear that it was an organization for everyone.” The response the team came back with was to build an Institute: a department that could cross all other departments and schools.

      While Dahleh and others on the committee were creating this blueprint for the future, the events that would lead early IDSS hires like Caroline Uhler to join the team were also beginning to take shape. Uhler, now an MIT professor of computer science and co-director of the Eric and Wendy Schmidt Center at the Broad Institute, was a panelist at the celebration discussing statistics and human health.

      In 2015, Uhler was a faculty member at the Institute of Science and Technology in Austria looking to move back to the U.S. “I was looking for positions in all different types of departments related to statistics, including electrical engineering and computer science, which were areas not related to my degree,” Uhler says. “What really got me to MIT was Munther’s vision for building a modern type of statistics, and the unique opportunity to be part of building what statistics should be moving forward.”

      The breadth of the Statistics and Data Science Center has given it a unique and a robust character that makes for an attractive collaborative environment at MIT. “A lot of IDSS’s impact has been in giving people like me a home,” Uhler adds. “By building an institute for statistics that is across all schools instead of housed within a single department, it has created a home for everyone who is interested in the field.”

      Filling the gap

      For Ali Jadbabaie, former IDSS associate director and another early IDSS hire, being in the right place at the right time landed him in the center of it all. A control theory expert and network scientist by training, Jadbabaie first came to MIT during a sabbatical from his position as a professor at the University of Pennsylvania.

      “My time at MIT coincided with the early discussions around forming IDSS and given my experience they asked me to stay and help with its creation,” Jadbabaie says. He is now head of the Department of Civil and Environmental Engineering at MIT, and he spoke at the celebration about a new MIT major in climate system science and engineering.

      A critical early accomplishment of IDSS was the creation of a doctoral program in social and engineering systems (SES), which has the goal of educating and fostering the success of a new type of PhD student, says Jadbabaie.

      “We realized we had this opportunity to educate a new type of PhD student who was conversant in the math of information sciences and statistics in addition to an understanding of a domain — infrastructures, climate, political polarization — in which problems arise,” he says. “This program would provide training in statistics and data science, the math of information sciences and a branch of social science that is relevant to their domain.”

      “SES has been filling a gap,” adds Jadbabaie. “We wanted to bring quantitative reasoning to areas in social sciences, particularly as they interact with complex engineering systems.”

      “My first year at MIT really broadened my horizon in terms of what was available and exciting,” says Manxi Wu, a member of the first cohort of students in the SES program after starting out in the Master of Science in Transportation (MST) program. “My advisor introduced me to a number of interesting topics at the intersection of game theory, economics, and engineering systems, and in my second year I realized my interest was really about the societal scale systems, with transportation as my go-to application area when I think about how to make an impact in the real world.”

      Wu, now an assistant professor in the School of Operations Research and Information Engineering at Cornell, was a panelist at the Celebration’s session on smart infrastructure systems. She says that the beauty of the SES program lies in its ability to create a common ground between groups of students and researchers who all have different applications interests but share an eagerness to sharpen their technical skills.

      “While we may be working on very different application areas, the core methodologies, such as mathematical tools for data science and probability optimization, create a common language,” Wu says. “We are all capable of speaking the technical language, and our diversified interests give us even more to talk about.”

      In addition to the PhD program, IDSS has helped bring quality MIT programming to people around the globe with its MicroMasters Program in Statistics and Data Science (SDS), which recently celebrated the certification of over 1,000 learners. The MicroMasters is just one offering in the newly-minted IDSSx, a collection of online learning opportunities for learners at different skill levels and interests.

      “The impact of branding what MIT-IDSS does across the globe has been great,” Dahleh says. “In addition, we’ve created smaller online programs for continued education in data science and machine learning, which I think is also critical in educating the community at large.”

      Hopes for the future

      Through all of its accomplishments, the core mission of IDSS has never changed.

      “The belief was always to create an institute focused on how data science can be used to solve pressing societal problems,” Dahleh says. “The organizational structure of IDSS as an MIT Institute has enabled it to promote data and systems as a transdiciplinary area that embeds in every domain to support its mission. This reverse ownership structure will continue to strengthen the presence of IDSS in MIT and will make it an essential unit within the Schwarzman College of Computing.”

      As Dahleh prepares to step down from his role, and Professor Martin Wainwright gets ready to fill his (very big) shoes as director, Dahleh’s colleagues say the real key to the success of IDSS all started with his passion and vision.

      “Creating a new academic unit within MIT is actually next to impossible,” Jadbabaie says. “It requires structural changes, as well as someone who has a strong understanding of multiple areas, who knows how to get people to work together collectively, and who has a mission.”

      “The most important thing is that he was inclusive,” he adds. “He didn’t try to create a gate around it and say these people are in and these people are not. I don’t think this would have ever happened without Munther at the helm.” More

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      Martin Wainwright named director of the Institute for Data, Systems, and Society

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      Martin Wainwright, the Cecil H. Green Professor in MIT’s departments of Electrical Engineering and Computer Science (EECS) and Mathematics, has been named the new director of the Institute for Data, Systems, and Society (IDSS), effective July 1.

      “Martin is a widely recognized leader in statistics and machine learning — both in research and in education. In taking on this leadership role in the college, Martin will work to build up the human and institutional behavior component of IDSS, while strengthening initiatives in both policy and statistics, and collaborations within the institute, across MIT, and beyond,” says Daniel Huttenlocher, dean of the MIT Schwarzman College of Computing and the Henry Ellis Warren Professor of Electrical Engineering and Computer Science. “I look forward to working with him and supporting his efforts in this next chapter for IDSS.”

      “Martin holds a strong belief in the value of theoretical, experimental, and computational approaches to research and in facilitating connections between them. He also places much importance in having practical, as well as academic, impact,” says Asu Ozdaglar, deputy dean of academics for the MIT Schwarzman College of Computing, department head of EECS, and the MathWorks Professor of Electrical Engineering and Computer Science. “As the new director of IDSS, he will undoubtedly bring these tenets to the role in advancing the mission of IDSS and helping to shape its future.”

      A principal investigator in the Laboratory for Information and Decision Systems and the Statistics and Data Science Center, Wainwright joined the MIT faculty in July 2022 from the University of California at Berkeley, where he held the Howard Friesen Chair with a joint appointment between the departments of Electrical Engineering and Computer Science and Statistics.

      Wainwright received his bachelor’s degree in mathematics from the University of Waterloo, Canada, and doctoral degree in electrical engineering and computer science from MIT. He has received a number of awards and recognition, including an Alfred P. Sloan Foundation Fellowship, and best paper awards from the IEEE Signal Processing Society, IEEE Communications Society, and IEEE Information Theory and Communication Societies. He has also been honored with the Medallion Lectureship and Award from the Institute of Mathematical Statistics, and the COPSS Presidents’ Award from the Joint Statistical Societies. He was a section lecturer with the International Congress of Mathematicians in 2014 and received the Blackwell Award from the Institute of Mathematical Statistics in 2017.

      He is the author of “High-dimensional Statistics: A Non-Asymptotic Viewpoint” (Cambridge University Press, 2019), and is coauthor on several books, including on graphical models and on sparse statistical modeling.

      Wainwright succeeds Munther Dahleh, the William A. Coolidge Professor in EECS, who has helmed IDSS since its founding in 2015.

      “I am grateful to Munther and thank him for his leadership of IDSS. As the founding director, he has led the creation of a remarkable new part of MIT,” says Huttenlocher. More

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      Democratizing education: Bringing MIT excellence to the masses

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      How do you quantify the value of education or measure success? For the team behind the MIT Institute for Data, Systems, and Society’s (IDSS) MicroMasters Program in Statistics and Data Science (SDS), providing over 1,000 individuals from around the globe with access to MIT-level programming feels like a pretty good place to start. 

      Thanks to the MIT-conceived MicroMasters-style format, SDS faculty director Professor Devavrat Shah and his colleagues have eliminated the physical restrictions created by a traditional brick-and-mortar education, allowing 1,178 learners and counting from 89 countries access to an MIT education.

      “Taking classes from a Nobel Prize winner doesn’t happen every day,” says Oscar Vele, a strategic development worker for the town of Cuenca, Ecuador. “My dream has always been to study at MIT. I knew it was not easy — now, through this program, my dream came true.”

      “With an online forum, in principle, admission is no longer the gate — the merit is a gate,” says Shah. “If you take a class that is MIT-level, and if you perform at MIT-level, then you should get MIT-level credentials.”

      The MM SDS program, delivered in collaboration with MIT Open Learning, plays a key role in the IDSS mission of advancing education in data science, and supports MIT’s overarching belief that everyone should be able to access a quality education no matter what their life circumstances may be.

      “Getting a program like this up and running to the point where it has credentials and credibility across the globe, is an important milestone for us,” says Shah. “Basically, for us, it says we are here to stay, and we are just getting started.”

      Since the program launched in 2018, Shah says he and his team have seen learners from all walks of life, from high-schoolers looking for a challenge to late-in-life learners looking to either evolve or refresh their knowledge.

      “Then there are individuals who want to prove to themselves that they can achieve serious knowledge and build a career,” Shah says. “Circumstances throughout their lives, whether it’s the country or socioeconomic conditions they’re born in, they have never had the opportunity to do something like this, and now they have an MIT-level education and credentials, which is a huge deal for them.”

      Many learners overcome challenges to complete the program, from financial hardships to balancing work, home life, and coursework, and finding private, internet-enabled space for learning — not to mention the added complications of a global pandemic. One Ukrainian learner even finished the program after fleeing her apartment for a bomb shelter.

      Remapping the way to a graduate degree

      For Diogo da Silva Branco Magalhaes, a 44-year-old lifelong learner, curiosity and the desire to evolve within his current profession brought him to the MicroMasters program. Having spent 15 years working in the public transport sector, da Silva Branco Magalhaes had a very specific challenge at the front of his mind: artificial intelligence.

      “It’s not science fiction; it’s already here,” he says. “Think about autonomous vehicles, on-demand transportation, mobility as a service — AI and data, in particular, are the driving force of a number of disruptions that will affect my industry.”

      When he signed up for the MicroMasters Program in Statistics and Data Science, da Silva Branco Magalhaes’ said he had no long-term plans, but was taking a first step. “I just wanted to have a first contact with this reality, understand the basics, and then let’s see how it goes,” he describes.

      Now, after earning his credentials in 2021, he finds himself a few weeks into an accelerated master’s program at Northwestern University, one of several graduate pathways supported by the MM SDS program.

      “I was really looking to gain some basic background knowledge; I didn’t expect the level of quality and depth they were able to provide in an online lecture format,” he says. “Having access to this kind of content — it’s a privilege, and now that we have it, we have to make the most of it.”

      A refreshing investment

      As an applied mathematician with 15 years of experience in the U.S. defense sector, Celia Wilson says she felt comfortable with her knowledge, though not 100 percent confident that her math skills could stand up against the next generation.

      “I felt I was getting left behind,” she says. “So I decided to take some time out and invest in myself, and this program was a great opportunity to systematize and refresh my knowledge of statistics and data science.”

      Since completing the course, Wilson says she has secured a new job as a director of data and analytics, where she is confident in her ability to manage a team of the “new breed of data scientists.” It turns out, however, that completing the program has given her an even greater gift than self-confidence.

      “Most importantly,” she adds, “it’s inspired my daughters to tell anyone who will listen that math is definitely for girls.”

      Connecting an engaged community

      Each course is connected to an online forum that allows learners to enhance their experience through real-time conversations with others in their cohort.

      “We have worked hard to provide a scalable version of the traditional teaching assistant support system that you would get in a usual on-campus class, with a great online forum for people to connect with each other as learners,” Shah says.

      David Khachatrian, a data scientist working on improving the drug discovery pipeline, says that leveraging the community to hone his ability to “think clearly and communicate effectively with others” mattered more than anything.

      “Take the opportunity to engage with your community of fellow learners and facilitators — answer questions for others to give back to the community, solidify your own understanding, and practice your ability to explain clearly,” Khachatrian says. “These skills and behaviors will help you to succeed not just in SDS, but wherever you go in the future.”

      “There were a lot of active contributions from a lot of learners and I felt it was really a very strong component of the course,” da Silva Branco Magalhaes adds. “I had some offline contact with other students who are connections that I’ve kept up with to this day.”

      A solid path forward

      “We have a dedicated team supporting the MM SDS community on the MIT side,” Shah says, citing the contributions of Karene Chu, MM SDS assistant director of education; Susana Kevorkova, the MM SDS program manager; and Jeremy Rossen, MM program coordinator. “They’ve done so much to ensure the success of the program and our learners, and they are constantly adding value to the program — like identifying real-time supplementary opportunities for learners to participate in, including the IDSS Policy Hackathon.”

      The program now holds online “graduation” ceremonies, where credential holders from all over the world share their experiences. Says Shah, who looks forward to celebrating the next 1,000 learners: “Every time I think about it, I feel emotional. It feels great, and it keeps us going.” More

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      Research, education, and connection in the face of war

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      When Russian forces invaded Ukraine in February 2022, Tetiana Herasymova had several decisions to make: What should she do, where should she live, and should she take her MITx MicroMasters capstone exams? She had registered for the Statistics and Data Science Program’s final exams just days prior to moving out of her apartment and into a bomb shelter. Although it was difficult to focus on studying and preparations with air horns sounding overhead and uncertainty lingering around her, she was determined to try. “I wouldn’t let the aggressor in the war squash my dreams,” she says.

      A love of research and the desire to improve teaching 

      An early love of solving puzzles and problems for fun piqued Herasymova’s initial interest in mathematics. When she later pursued her PhD in mathematics at Kiev National Taras Shevchenko University, Herasymova’s love of math evolved into a love of research. Throughout Herasymova’s career, she’s worked to close the gap between scientific researchers and educators. Starting as a math tutor at MBA Strategy, a company that prepares Ukrainian leaders for qualifying standardized tests for MBA programs, she was later promoted as the head of their test preparation department. Afterward, she moved on to an equivalent position at ZNOUA, a new project that prepared high school students for Ukraine’s standardized test, and she eventually became ZNOUA’s CEO.

      In 2018, she founded Prosteer, a “self-learning community” of educators who share research, pedagogy, and experience to learn from one another. “It’s really interesting to have a community of teachers from different domains,” she says, speaking of educators and researchers whose specialties range across language, mathematics, physics, music, and more.

      Implementing new pedagogical research in the classroom is often up to educators who seek out studies on an individual basis, Herasymova has found. “Lots of scientists are not practitioners,” she says, and the reverse is also true. She only became more determined to build these connections once she was promoted to head of test preparation at MBA Strategy because she wanted to share more effective pedagogy with the tutors she was mentoring.

      First, Herasymova knew she needed a way to measure the teachers’ effectiveness. She was able to determine whether students who received the company’s tutoring services improved their scores. Moreover, Ukraine keeps an open-access database of national standardized test scores, so anyone could analyze the data in hopes of improving the level of education in the country. She says, “I could do some analytics because I am a mathematician, but I knew I could do much more with this data if I knew data science and machine learning knowledge.”

      That’s why Herasymova sought out the MITx MicroMasters Program in Statistics and Data Science offered by the MIT Institute for Data, Systems, and Society (IDSS). “I wanted to learn the fundamentals so I could join the Learning Analytics domain,” she says. She was looking for a comprehensive program that covered the foundations without being overly basic. “I had some knowledge from the ground, so I could see the deepness of that course,” she says. Because of her background as an instructional designer, she thought the MicroMasters curriculum was well-constructed, calling the variety of videos, practice problems, and homework assignments that encouraged learners to approach the course material in different ways, “a perfect experience.”

      Another benefit of the MicroMasters program was its online format. “I had my usual work, so it was impossible to study in a stationary way,” she says. She found the structure to be more flexible than other programs. “It’s really great that you can construct your course schedule your own way, especially with your own adult life,” she says.

      Determination and support in the midst of war

      When the war first forced Herasymova to flee her apartment, she had already registered to take the exams for her four courses. “It was quite hard to prepare for exams when you could hear explosions outside of the bomb shelter,” she says. She and other Ukranians were invited to postpone their exams until the following session, but the next available testing period wouldn’t be held until October. “It was a hard decision, but I had to allow myself to try,” she says. “For all people in Ukraine, when you don’t know if you’re going to live or die, you try to live in the now. You have to appreciate every moment and what life brings to you. You don’t say, ‘Someday’ — you do it today or tomorrow.”

      In addition to emotional support from her boyfriend, Herasymova had a group of friends who had also enrolled in the program, and they supported each other through study sessions and an ongoing chat. Herasymova’s personal support network helped her accomplish what she set out to do with her MicroMasters program, and in turn, she was able to support her professional network. While Prosteer halted its regular work during the early stages of the war, Herasymova was determined to support the community of educators and scientists that she had built. They continued meeting weekly to exchange ideas as usual. “It’s intrinsic motivation,” she says. They managed to restore all of their activities by October.

      Despite the factors stacked against her, Herasymova’s determination paid off — she passed all of her exams in May, the final step to earning her MicroMasters certificate in statistics and data science. “I just couldn’t believe it,” she says. “It was definitely a bifurcation point. The moment when you realize that you have something to rely on, and that life is just beginning to show all its diversity despite the fact that you live in war.” With her newly minted certificate in hand, Herasymova has continued her research on the effectiveness of educational models — analyzing the data herself — with a summer research program at New York University. 

      The student becomes the master

      After moving seven times between February and October, heading west from Kyiv until most recently settling near the border of Poland, Herasymova hopes she’s moved for the last time. Ukrainian Catholic University offered her a position teaching both mathematics and programming. Before enrolling in the MicroMasters Program in Statistics and Data Science, she had some prior knowledge of programming languages and mathematical algorithms, but she didn’t know Python. She took MITx’s Introduction to Computer Science and Programming Using Python to prepare. “It gave me a huge step forward,” she says. “I learned a lot. Now, not only can I work with Python machine learning models in programming language R, I also have knowledge of the big picture of the purpose and the point to do so.”

      In addition to the skills the MicroMasters Program trained her in, she gained firsthand experience in learning new subjects and exploring topics more deeply. She will be sharing that practice with the community of students and teachers she’s built, plus, she plans on guiding them through this course during the next year. As a continuation of her own educational growth, says she’s looking forward to her next MITx course this year, Data Analysis.

      Herasymova advises that the best way to keep progressing is investing a lot of time. “Adults don’t want to hear this, but you need one or two years,” she says. “Allow yourself to be stupid. If you’re an expert in one domain and want to switch to another, or if you want to understand something new, a lot of people don’t ask questions or don’t ask for help. But from this point, if I don’t know something, I know I should ask for help because that’s the start of learning. With a fixed mindset, you won’t grow.”

      July 2022 MicroMasters Program Joint Completion Celebration. Ukrainian student Tetiana Herasymova, who completed her program amid war in her home country, speaks at 43:55. More