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    Inclusive research for social change

    Pair a decades-old program dedicated to creating research opportunities for underrepresented minorities and populations with a growing initiative committed to tackling the very issues at the heart of such disparities, and you’ll get a transformative partnership that only MIT can deliver. 

    Since 1986, the MIT Summer Research Program (MSRP) has led an institutional effort to prepare underrepresented students (minorities, women in STEM, or students with low socioeconomic status) for doctoral education by pairing them with MIT labs and research groups. For the past three years, the Initiative on Combatting Systemic Racism (ICSR), a cross-disciplinary research collaboration led by MIT’s Institute for Data, Systems, and Society (IDSS), has joined them in their mission, helping bring the issue full circle by providing MSRP students with the opportunity to use big data and computational tools to create impactful changes toward racial equity.

    “ICSR has further enabled our direct engagement with undergrads, both within and outside of MIT,” says Fotini Christia, the Ford International Professor of the Social Sciences, associate director of IDSS, and co-organizer for the initiative. “We’ve found that this line of research has attracted students interested in examining these topics with the most rigorous methods.”

    The initiative fits well under the IDSS banner, as IDSS research seeks solutions to complex societal issues through a multidisciplinary approach that includes statistics, computation, modeling, social science methodologies, human behavior, and an understanding of complex systems. With the support of faculty and researchers from all five schools and the MIT Schwarzman College of Computing, the objective of ICSR is to work on an array of different societal aspects of systemic racism through a set of verticals including policing, housing, health care, and social media.

    Where passion meets impact

    Grinnell senior Mia Hines has always dreamed of using her love for computer science to support social justice. She has experience working with unhoused people and labor unions, and advocating for Indigenous peoples’ rights. When applying to college, she focused her essay on using technology to help Syrian refugees.

    “As a Black woman, it’s very important to me that we focus on these areas, especially on how we can use technology to help marginalized communities,” Hines says. “And also, how do we stop technology or improve technology that is already hurting marginalized communities?”   

    Through MSRP, Hines was paired with research advisor Ufuoma Ovienmhada, a fourth-year doctoral student in the Department of Aeronautics and Astronautics at MIT. A member of Professor Danielle Wood’s Space Enabled research group at MIT’s Media Lab, Ovienmhada received funding from an ICSR Seed Grant and NASA’s Applied Sciences Program to support her ongoing research measuring environmental injustice and socioeconomic disparities in prison landscapes. 

    “I had been doing satellite remote sensing for environmental challenges and sustainability, starting out looking at coastal ecosystems, when I learned about an issue called ‘prison ecology,’” Ovienmhada explains. “This refers to the intersection of mass incarceration and environmental justice.”

    Ovienmhada’s research uses satellite remote sensing and environmental data to characterize exposures to different environmental hazards such as air pollution, extreme heat, and flooding. “This allows others to use these datasets for real-time advocacy, in addition to creating public awareness,” she says.

    Focused especially on extreme heat, Hines used satellite remote sensing to monitor the fluctuation of temperature to assess the risk being imposed on prisoners, including death, especially in states like Texas, where 75 percent of prisons either don’t have full air conditioning or have none at all.

    “Before this project I had done little to no work with geospatial data, and as a budding data scientist, getting to work with and understanding different types of data and resources is really helpful,” Hines says. “I was also funded and afforded the flexibility to take advantage of IDSS’s Data Science and Machine Learning online course. It was really great to be able to do that and learn even more.”

    Filling the gap

    Much like Hines, Harvey Mudd senior Megan Li was specifically interested in the IDSS-supported MSRP projects. She was drawn to the interdisciplinary approach, and she seeks in her own work to apply computational methods to societal issues and to make computer science more inclusive, considerate, and ethical. 

    Working with Aurora Zhang, a grad student in IDSS’s Social and Engineering Systems PhD program, Li used county-level data on income and housing prices to quantify and visualize how affordability based on income alone varies across the United States. She then expanded the analysis to include assets and debt to determine the most common barriers to home ownership.

    “I spent my day-to-day looking at census data and writing Python scripts that could work with it,” reports Li. “I also reached out to the Census Bureau directly to learn a little bit more about how they did their data collection, and discussed questions related to some of their previous studies and working papers that I had reviewed.” 

    Outside of actual day-to-day research, Li says she learned a lot in conversations with fellow researchers, particularly changing her “skeptical view” of whether or not mortgage lending algorithms would help or hurt home buyers in the approval process. “I think I have a little bit more faith now, which is a good thing.”

    “Harvey Mudd is undergraduate-only, and while professors do run labs here, my specific research areas are not well represented,” Li says. “This opportunity was enormous in that I got the experience I need to see if this research area is actually something that I want to do long term, and I got more mirrors into what I would be doing in grad school from talking to students and getting to know faculty.”

    Closing the loop

    While participating in MSRP offered crucial research experience to Hines, the ICSR projects enabled her to engage in topics she’s passionate about and work that could drive tangible societal change.

    “The experience felt much more concrete because we were working on these very sophisticated projects, in a supportive environment where people were very excited to work with us,” she says.

    A significant benefit for Li was the chance to steer her research in alignment with her own interests. “I was actually given the opportunity to propose my own research idea, versus supporting a graduate student’s work in progress,” she explains. 

    For Ovienmhada, the pairing of the two initiatives solidifies the efforts of MSRP and closes a crucial loop in diversity, equity, and inclusion advocacy. 

    “I’ve participated in a lot of different DEI-related efforts and advocacy and one thing that always comes up is the fact that it’s not just about bringing people in, it’s also about creating an environment and opportunities that align with people’s values,” Ovienmhada says. “Programs like MSRP and ICSR create opportunities for people who want to do work that’s aligned with certain values by providing the needed mentoring and financial support.” More

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    Making genetic prediction models more inclusive

    While any two human genomes are about 99.9 percent identical, genetic variation in the remaining 0.1 percent plays an important role in shaping human diversity, including a person’s risk for developing certain diseases.

    Measuring the cumulative effect of these small genetic differences can provide an estimate of an individual’s genetic risk for a particular disease or their likelihood of having a particular trait. However, the majority of models used to generate these “polygenic scores” are based on studies done in people of European descent, and do not accurately gauge the risk for people of non-European ancestry or people whose genomes contain a mixture of chromosome regions inherited from previously isolated populations, also known as admixed ancestry.

    In an effort to make these genetic scores more inclusive, MIT researchers have created a new model that takes into account genetic information from people from a wider diversity of genetic ancestries across the world. Using this model, they showed that they could increase the accuracy of genetics-based predictions for a variety of traits, especially for people from populations that have been traditionally underrepresented in genetic studies.

    “For people of African ancestry, our model proved to be about 60 percent more accurate on average,” says Manolis Kellis, a professor of computer science in MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) and a member of the Broad Institute of MIT and Harvard. “For people of admixed genetic backgrounds more broadly, who have been excluded from most previous models, the accuracy of our model increased by an average of about 18 percent.”

    The researchers hope their more inclusive modeling approach could help improve health outcomes for a wider range of people and promote health equity by spreading the benefits of genomic sequencing more widely across the globe.

    “What we have done is created a method that allows you to be much more accurate for admixed and ancestry-diverse individuals, and ensure the results and the benefits of human genetics research are equally shared by everyone,” says MIT postdoc Yosuke Tanigawa, the lead and co-corresponding author of the paper, which appears today in open-access form in the American Journal of Human Genetics. The researchers have made all of their data publicly available for the broader scientific community to use.

    More inclusive models

    The work builds on the Human Genome Project, which mapped all of the genes found in the human genome, and on subsequent large-scale, cohort-based studies of how genetic variants in the human genome are linked to disease risk and other differences between individuals.

    These studies showed that the effect of any individual genetic variant on its own is typically very small. Together, these small effects add up and influence the risk of developing heart disease or diabetes, having a stroke, or being diagnosed with psychiatric disorders such as schizophrenia.

    “We have hundreds of thousands of genetic variants that are associated with complex traits, each of which is individually playing a weak effect, but together they are beginning to be predictive for disease predispositions,” Kellis says.

    However, most of these genome-wide association studies included few people of non-European descent, so polygenic risk models based on them translate poorly to non-European populations. People from different geographic areas can have different patterns of genetic variation, shaped by stochastic drift, population history, and environmental factors — for example, in people of African descent, genetic variants that protect against malaria are more common than in other populations. Those variants also affect other traits involving the immune system, such as counts of neutrophils, a type of immune cell. That variation would not be well-captured in a model based on genetic analysis of people of European ancestry alone.

    “If you are an individual of African descent, of Latin American descent, of Asian descent, then you are currently being left out by the system,” Kellis says. “This inequity in the utilization of genetic information for predicting risk of patients can cause unnecessary burden, unnecessary deaths, and unnecessary lack of prevention, and that’s where our work comes in.”

    Some researchers have begun trying to address these disparities by creating distinct models for people of European descent, of African descent, or of Asian descent. These emerging approaches assign individuals to distinct genetic ancestry groups, aggregate the data to create an association summary, and make genetic prediction models. However, these approaches still don’t represent people of admixed genetic backgrounds well.

    “Our approach builds on the previous work without requiring researchers to assign individuals or local genomic segments of individuals to predefined distinct genetic ancestry groups,” Tanigawa says. “Instead, we develop a single model for everybody by directly working on individuals across the continuum of their genetic ancestries.”

    In creating their new model, the MIT team used computational and statistical techniques that enabled them to study each individual’s unique genetic profile instead of grouping individuals by population. This methodological advancement allowed the researchers to include people of admixed ancestry, who made up nearly 10 percent of the UK Biobank dataset used for this study and currently account for about one in seven newborns in the United States.

    “Because we work at the individual level, there is no need for computing summary-level data for different populations,” Kellis says. “Thus, we did not need to exclude individuals of admixed ancestry, increasing our power by including more individuals and representing contributions from all populations in our combined model.”

    Better predictions

    To create their new model, the researchers used genetic data from more than 280,000 people, which was collected by UK Biobank, a large-scale biomedical database and research resource containing de-identified genetic, lifestyle, and health information from half a million U.K. participants. Using another set of about 81,000 held-out individuals from the UK Biobank, the researchers evaluated their model across 60 traits, which included traits related to body size and shape, such as height and body mass index, as well as blood traits such as white blood cell count and red blood cell count, which also have a genetic basis.

    The researchers found that, compared to models trained only on European-ancestry individuals, their model’s predictions are more accurate for all genetic ancestry groups. The most notable gain was for people of African ancestry, who showed 61 percent average improvements, even though they only made up about 1.5 percent of samples in UK Biobank. The researchers also saw improvements of 11 percent for people of South Asian descent and 5 percent for white British people. Predictions for people of admixed ancestry improved by about 18 percent.

    “When you bring all the individuals together in the training set, everybody contributes to the training of the polygenic score modeling on equal footing,” Tanigawa says. “Combined with increasingly more inclusive data collection efforts, our method can help leverage these efforts to improve predictive accuracy for all.”

    The MIT team hopes its approach can eventually be incorporated into tests of an individual’s risk of a variety of diseases. Such tests could be combined with conventional risk factors and used to help doctors diagnose disease or to help people manage their risk for certain diseases before they develop.

    “Our work highlights the power of diversity, equity, and inclusion efforts in the context of genomics research,” Tanigawa says.

    The researchers now hope to add even more data to their model, including data from the United States, and to apply it to additional traits that they didn’t analyze in this study.

    “This is just the start,” Kellis says. “We can’t wait to see more people join our effort to propel inclusive human genetics research.”

    The research was funded by the National Institutes of Health. More

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    How an archeological approach can help leverage biased data in AI to improve medicine

    The classic computer science adage “garbage in, garbage out” lacks nuance when it comes to understanding biased medical data, argue computer science and bioethics professors from MIT, Johns Hopkins University, and the Alan Turing Institute in a new opinion piece published in a recent edition of the New England Journal of Medicine (NEJM). The rising popularity of artificial intelligence has brought increased scrutiny to the matter of biased AI models resulting in algorithmic discrimination, which the White House Office of Science and Technology identified as a key issue in their recent Blueprint for an AI Bill of Rights. 

    When encountering biased data, particularly for AI models used in medical settings, the typical response is to either collect more data from underrepresented groups or generate synthetic data making up for missing parts to ensure that the model performs equally well across an array of patient populations. But the authors argue that this technical approach should be augmented with a sociotechnical perspective that takes both historical and current social factors into account. By doing so, researchers can be more effective in addressing bias in public health. 

    “The three of us had been discussing the ways in which we often treat issues with data from a machine learning perspective as irritations that need to be managed with a technical solution,” recalls co-author Marzyeh Ghassemi, an assistant professor in electrical engineering and computer science and an affiliate of the Abdul Latif Jameel Clinic for Machine Learning in Health (Jameel Clinic), the Computer Science and Artificial Intelligence Laboratory (CSAIL), and Institute of Medical Engineering and Science (IMES). “We had used analogies of data as an artifact that gives a partial view of past practices, or a cracked mirror holding up a reflection. In both cases the information is perhaps not entirely accurate or favorable: Maybe we think that we behave in certain ways as a society — but when you actually look at the data, it tells a different story. We might not like what that story is, but once you unearth an understanding of the past you can move forward and take steps to address poor practices.” 

    Data as artifact 

    In the paper, titled “Considering Biased Data as Informative Artifacts in AI-Assisted Health Care,” Ghassemi, Kadija Ferryman, and Maxine Mackintosh make the case for viewing biased clinical data as “artifacts” in the same way anthropologists or archeologists would view physical objects: pieces of civilization-revealing practices, belief systems, and cultural values — in the case of the paper, specifically those that have led to existing inequities in the health care system. 

    For example, a 2019 study showed that an algorithm widely considered to be an industry standard used health-care expenditures as an indicator of need, leading to the erroneous conclusion that sicker Black patients require the same level of care as healthier white patients. What researchers found was algorithmic discrimination failing to account for unequal access to care.  

    In this instance, rather than viewing biased datasets or lack of data as problems that only require disposal or fixing, Ghassemi and her colleagues recommend the “artifacts” approach as a way to raise awareness around social and historical elements influencing how data are collected and alternative approaches to clinical AI development. 

    “If the goal of your model is deployment in a clinical setting, you should engage a bioethicist or a clinician with appropriate training reasonably early on in problem formulation,” says Ghassemi. “As computer scientists, we often don’t have a complete picture of the different social and historical factors that have gone into creating data that we’ll be using. We need expertise in discerning when models generalized from existing data may not work well for specific subgroups.” 

    When more data can actually harm performance 

    The authors acknowledge that one of the more challenging aspects of implementing an artifact-based approach is being able to assess whether data have been racially corrected: i.e., using white, male bodies as the conventional standard that other bodies are measured against. The opinion piece cites an example from the Chronic Kidney Disease Collaboration in 2021, which developed a new equation to measure kidney function because the old equation had previously been “corrected” under the blanket assumption that Black people have higher muscle mass. Ghassemi says that researchers should be prepared to investigate race-based correction as part of the research process. 

    In another recent paper accepted to this year’s International Conference on Machine Learning co-authored by Ghassemi’s PhD student Vinith Suriyakumar and University of California at San Diego Assistant Professor Berk Ustun, the researchers found that assuming the inclusion of personalized attributes like self-reported race improve the performance of ML models can actually lead to worse risk scores, models, and metrics for minority and minoritized populations.  

    “There’s no single right solution for whether or not to include self-reported race in a clinical risk score. Self-reported race is a social construct that is both a proxy for other information, and deeply proxied itself in other medical data. The solution needs to fit the evidence,” explains Ghassemi. 

    How to move forward 

    This is not to say that biased datasets should be enshrined, or biased algorithms don’t require fixing — quality training data is still key to developing safe, high-performance clinical AI models, and the NEJM piece highlights the role of the National Institutes of Health (NIH) in driving ethical practices.  

    “Generating high-quality, ethically sourced datasets is crucial for enabling the use of next-generation AI technologies that transform how we do research,” NIH acting director Lawrence Tabak stated in a press release when the NIH announced its $130 million Bridge2AI Program last year. Ghassemi agrees, pointing out that the NIH has “prioritized data collection in ethical ways that cover information we have not previously emphasized the value of in human health — such as environmental factors and social determinants. I’m very excited about their prioritization of, and strong investments towards, achieving meaningful health outcomes.” 

    Elaine Nsoesie, an associate professor at the Boston University of Public Health, believes there are many potential benefits to treating biased datasets as artifacts rather than garbage, starting with the focus on context. “Biases present in a dataset collected for lung cancer patients in a hospital in Uganda might be different from a dataset collected in the U.S. for the same patient population,” she explains. “In considering local context, we can train algorithms to better serve specific populations.” Nsoesie says that understanding the historical and contemporary factors shaping a dataset can make it easier to identify discriminatory practices that might be coded in algorithms or systems in ways that are not immediately obvious. She also notes that an artifact-based approach could lead to the development of new policies and structures ensuring that the root causes of bias in a particular dataset are eliminated. 

    “People often tell me that they are very afraid of AI, especially in health. They’ll say, ‘I’m really scared of an AI misdiagnosing me,’ or ‘I’m concerned it will treat me poorly,’” Ghassemi says. “I tell them, you shouldn’t be scared of some hypothetical AI in health tomorrow, you should be scared of what health is right now. If we take a narrow technical view of the data we extract from systems, we could naively replicate poor practices. That’s not the only option — realizing there is a problem is our first step towards a larger opportunity.”  More

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    Driving toward data justice

    As a person with a mixed-race background who has lived in four different cities, Amelia Dogan describes her early life as “growing up in a lot of in-betweens.” Now an MIT senior, she continues to link different perspectives together, working at the intersection of urban planning, computer science, and social justice.

    Dogan was born in Canada but spent her high school years in Philadelphia, where she developed a strong affinity for the city.  

    “I love Philadelphia to death,” says Dogan. “It’s my favorite place in the world. The energy in the city is amazing — I’m so sad I wasn’t there for the Super Bowl this year — but it is a city with really big disparities. That drives me to do the research that I do and shapes the things that I care about.”

    Dogan is double-majoring in urban science and planning with computer science and in American studies. She decided on the former after participating in the pre-orientation program offered by the Department of Urban Studies and Planning, which provides an introduction to both the department and the city of Boston. She followed that up with a UROP research project with the West Philadelphia Landscape Project, putting together historical census data on housing and race to find patterns for use in community advocacy.

    After taking WGS.231 (Writing About Race), a course offered by the Program in Women’s and Gender Studies, her first year at MIT, Dogan realized there was a lot of crosstalk between urban planning, computer science, and the social sciences.

    “There’s a lot of critical social theory that I want to have background in to make me a better planner or a better computer scientist,” says Dogan. “There’s also a lot of issues around fairness and participation in computer science, and a lot of computer scientists are trying to reinvent the wheel when there’s already really good, critical social science research and theory behind this.”

    Data science and feminism

    Dogan’s first year at MIT was interrupted by the onset of the Covid-19 pandemic, but there was a silver lining. An influx of funding to keep students engaged while attending school virtually enabled her to join the Data + Feminism Lab to work on a case study examining three places in Philadelphia with historical names that were renamed after activist efforts.

    In her first year at MIT, Dogan worked several UROPs to hone her own skills and find the best research fit. Besides the West Philadelphia Land Project, she worked on two projects within the MIT Sloan School of Management. The first involved searching for connections between entrepreneurship and immigration among Fortune 500 founders. The second involved interviewing warehouse workers and writing a report on their quality of life.

    Dogan has now spent three years in the Data + Feminism Lab under Associate Professor Catherine D’Ignazio, where she is particularly interested in how technology can be used by marginalized communities to invert historical power imbalances. A key concept in the lab’s work is that of counterdata, which are produced by civil society groups or individuals in order to counter missing data or to challenge existing official data.

    Most recently, she completed a SuperUROP project investigating how femicide data activist organizations use social media. She analyzed 600 social media posts by organizations across the U.S. and Canada. The work built off the lab’s greater body of work with these groups, which Dogan has contributed to by annotating news articles for machine-learning models.

    “Catherine works a lot at the intersection of data issues and feminism. It just seemed like the right fit for me,” says Dogan. “She’s my academic advisor, she’s my research advisor, and is also a really good mentor.”

    Advocating for the student experience

    Outside of the classroom, Dogan is a strong advocate for improving the student experience, particularly when it intersects with identity. An executive board member of the Asian American Initiative (AAI), she also sits on the student advisory council for the Office of Minority Education.

    “Doing that institutional advocacy has been important to me, because it’s for things that I expected coming into college and had not come in prepared to fight for,” says Dogan. As a high schooler, she participated in programs run by the University of Pennsylvania’s Pan-Asian American Community House and was surprised to find that MIT did not have an equivalent organization.

    “Building community based upon identity is something that I’ve been really passionate about,” says Dogan. “For the past two years, I’ve been working with AAI on a list of recommendations for MIT. I’ve talked to alums from the ’90s who were a part of an Asian American caucus who were asking for the same things.”

    She also holds a leadership role with MIXED @ MIT, a student group focused on creating space for mixed-heritage students to explore and discuss their identities.

    Following graduation, Dogan plans to pursue a PhD in information science at the University of Washington. Her breadth of skills has given her a range of programs to choose from. No matter where she goes next, Dogan wants to pursue a career where she can continue to make a tangible impact.

    “I would love to be doing community-engaged research around data justice, using citizen science and counterdata for policy and social change,” she says. More

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    Simulating discrimination in virtual reality

    Have you ever been advised to “walk a mile in someone else’s shoes?” Considering another person’s perspective can be a challenging endeavor — but recognizing our errors and biases is key to building understanding across communities. By challenging our preconceptions, we confront prejudice, such as racism and xenophobia, and potentially develop a more inclusive perspective about others.

    To assist with perspective-taking, MIT researchers have developed “On the Plane,” a virtual reality role-playing game (VR RPG) that simulates discrimination. In this case, the game portrays xenophobia directed against a Malaysian America woman, but the approach can be generalized. Situated on an airplane, players can take on the role of characters from different backgrounds, engaging in dialogue with others while making in-game choices to a series of prompts. In turn, players’ decisions control the outcome of a tense conversation between the characters about cultural differences.

    As a VR RPG, “On the Plane” encourages players to take on new roles that may be outside of their personal experiences in the first person, allowing them to confront in-group/out-group bias by incorporating new perspectives into their understanding of different cultures. Players engage with three characters: Sarah, a first-generation Muslim American of Malaysian ancestry who wears a hijab; Marianne, a white woman from the Midwest with little exposure to other cultures and customs; or a flight attendant. Sarah represents the out group, Marianne is a member of the in group, and the flight staffer is a bystander witnessing an exchange between the two passengers.“This project is part of our efforts to harness the power of virtual reality and artificial intelligence to address social ills, such as discrimination and xenophobia,” says Caglar Yildirim, an MIT Computer Science and Artificial Intelligence Laboratory (CSAIL) research scientist who is a co-author and co-game designer on the project. “Through the exchange between the two passengers, players experience how one passenger’s xenophobia manifests itself and how it affects the other passenger. The simulation engages players in critical reflection and seeks to foster empathy for the passenger who was ‘othered’ due to her outfit being not so ‘prototypical’ of what an American should look like.”

    Yildirim worked alongside the project’s principal investigator, D. Fox Harrell, MIT professor of digital media and AI at CSAIL, the Program in Comparative Media Studies/Writing (CMS), and the Institute for Data, Systems, and Society (IDSS) and founding director of the MIT Center for Advanced Virtuality. “It is not possible for a simulation to give someone the life experiences of another person, but while you cannot ‘walk in someone else’s shoes’ in that sense, a system like this can help people recognize and understand the social patterns at work when it comes to issue like bias,” says Harrell, who is also co-author and designer on this project. “An engaging, immersive, interactive narrative can also impact people emotionally, opening the door for users’ perspectives to be transformed and broadened.” This simulation also utilizes an interactive narrative engine that creates several options for responses to in-game interactions based on a model of how people are categorized socially. The tool grants players a chance to alter their standing in the simulation through their reply choices to each prompt, affecting their affinity toward the other two characters. For example, if you play as the flight attendant, you can react to Marianne’s xenophobic expressions and attitudes toward Sarah, changing your affinities. The engine will then provide you with a different set of narrative events based on your changes in standing with others.

    To animate each avatar, “On the Plane” incorporates artificial intelligence knowledge representation techniques controlled by probabilistic finite state machines, a tool commonly used in machine learning systems for pattern recognition. With the help of these machines, characters’ body language and gestures are customizable: if you play as Marianne, the game will customize her mannerisms toward Sarah based on user inputs, impacting how comfortable she appears in front of a member of a perceived out group. Similarly, players can do the same from Sarah or the flight attendant’s point of view.In a 2018 paper based on work done in a collaboration between MIT CSAIL and the Qatar Computing Research Institute, Harrell and co-author Sercan Şengün advocated for virtual system designers to be more inclusive of Middle Eastern identities and customs. They claimed that if designers allowed users to customize virtual avatars more representative of their background, it might empower players to engage in a more supportive experience. Four years later, “On the Plane” accomplishes a similar goal, incorporating a Muslim’s perspective into an immersive environment.

    “Many virtual identity systems, such as avatars, accounts, profiles, and player characters, are not designed to serve the needs of people across diverse cultures. We have used statistical and AI methods in conjunction with qualitative approaches to learn where the gaps are,” they note. “Our project helps engender perspective transformation so that people will treat each other with respect and enhanced understanding across diverse cultural avatar representations.”

    Harrell and Yildirim’s work is part of the MIT IDSS’s Initiative on Combatting Systemic Racism (ICSR). Harrell is on the initiative’s steering committee and is the leader of the newly forming Antiracism, Games, and Immersive Media vertical, who study behavior, cognition, social phenomena, and computational systems related to race and racism in video games and immersive experiences.

    The researchers’ latest project is part of the ICSR’s broader goal to launch and coordinate cross-disciplinary research that addresses racially discriminatory processes across American institutions. Using big data, members of the research initiative develop and employ computing tools that drive racial equity. Yildirim and Harrell accomplish this goal by depicting a frequent, problematic scenario that illustrates how bias creeps into our everyday lives.“In a post-9/11 world, Muslims often experience ethnic profiling in American airports. ‘On the Plane’ builds off of that type of in-group favoritism, a well-established finding in psychology,” says MIT Professor Fotini Christia, director of the Sociotechnical Systems Research Center (SSRC) and associate director or IDSS. “This game also takes a novel approach to analyzing hardwired bias by utilizing VR instead of field experiments to simulate prejudice. Excitingly, this research demonstrates that VR can be used as a tool to help us better measure bias, combating systemic racism and other forms of discrimination.”“On the Plane” was developed on the Unity game engine using the XR Interaction Toolkit and Harrell’s Chimeria platform for authoring interactive narratives that involve social categorization. The game will be deployed for research studies later this year on both desktop computers and the standalone, wireless Meta Quest headsets. A paper on the work was presented in December at the 2022 IEEE International Conference on Artificial Intelligence and Virtual Reality. More

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    Empowering Cambridge youth through data activism

    For over 40 years, the Mayor’s Summer Youth Employment Program (MSYEP, or the Mayor’s Program) in Cambridge, Massachusetts, has been providing teenagers with their first work experience, but 2022 brought a new offering. Collaborating with MIT’s Personal Robots research group (PRG) and Responsible AI for Social Empowerment and Education (RAISE) this summer, MSYEP created a STEAM-focused learning site at the Institute. Eleven students joined the program to learn coding and programming skills through the lens of “Data Activism.”

    MSYEP’s partnership with MIT provides an opportunity for Cambridge high schoolers to gain exposure to more pathways for their future careers and education. The Mayor’s Program aims to respect students’ time and show the value of their work, so participants are compensated with an hourly wage as they learn workforce skills at MSYEP worksites. In conjunction with two ongoing research studies at MIT, PRG and RAISE developed the six-week Data Activism curriculum to equip students with critical-thinking skills so they feel prepared to utilize data science to challenge social injustice and empower their community.

    Rohan Kundargi, K-12 Community Outreach Administrator for MIT Office of Government and Community Relations (OGCR), says, “I see this as a model for a new type of partnership between MIT and Cambridge MSYEP. Specifically, an MIT research project that involves students from Cambridge getting paid to learn, research, and develop their own skills!”

    Cross-Cambridge collaboration

    Cambridge’s Office of Workforce Development initially contacted MIT OGCR about hosting a potential MSYEP worksite that taught Cambridge teens how to code. When Kundargi reached out to MIT pK-12 collaborators, MIT PRG’s graduate research assistant Raechel Walker proposed the Data Activism curriculum. Walker defines “data activism” as utilizing data, computing, and art to analyze how power operates in the world, challenge power, and empathize with people who are oppressed.

    Walker says, “I wanted students to feel empowered to incorporate their own expertise, talents, and interests into every activity. In order for students to fully embrace their academic abilities, they must remain comfortable with bringing their full selves into data activism.”

    As Kundargi and Walker recruited students for the Data Activism learning site, they wanted to make sure the cohort of students — the majority of whom are individuals of color — felt represented at MIT and felt they had the agency for their voice to be heard. “The pioneers in this field are people who look like them,” Walker says, speaking of well-known data activists Timnit Gebru, Rediet Abebe, and Joy Buolamwini.

    When the program began this summer, some of the students were not aware of the ways data science and artificial intelligence exacerbate systemic oppression in society, or some of the tools currently being used to mitigate those societal harms. As a result, Walker says, the students wanted to learn more about discriminatory design in every aspect of life. They were also interested in creating responsible machine learning algorithms and AI fairness metrics.

    A different side of STEAM

    The development and execution of the Data Activism curriculum contributed to Walker’s and postdoc Xiaoxue Du’s respective research at PRG. Walker is studying AI education, specifically creating and teaching data activism curricula for minoritized communities. Du’s research explores processes, assessments, and curriculum design that prepares educators to use, adapt, and integrate AI literacy curricula. Additionally, her research targets how to leverage more opportunities for students with diverse learning needs.

    The Data Activism curriculum utilizes a “libertatory computing” framework, a term Walker coined in her position paper with Professor Cynthia Breazeal, director of MIT RAISE, dean for digital learning, and head of PRG, and Eman Sherif, a then-undergraduate researcher from University of California at San Diego, titled “Liberty Computing for African American Students.” This framework ensures that students, especially minoritized students, acquire a sound racial identity, critical consciousness, collective obligation, liberation centered academic/achievement identity, as well as the activism skills to use computing to transform a multi-layered system of barriers in which racism persists. Walker says, “We encouraged students to demonstrate competency in every pillar because all of the pillars are interconnected and build upon each other.”

    Walker developed a series of interactive coding and project-based activities that focused on understanding systemic racism, utilizing data science to analyze systemic oppression, data drawing, responsible machine learning, how racism can be embedded into AI, and different AI fairness metrics.

    This was the students’ first time learning how to create data visualizations using the programming language Python and the data analysis tool Pandas. In one project meant to examine how different systems of oppression can affect different aspects of students’ own identities, students created datasets with data from their respective intersectional identities. Another activity highlighted African American achievements, where students analyzed two datasets about African American scientists, activists, artists, scholars, and athletes. Using the data visualizations, students then created zines about the African Americans who inspired them.

    RAISE hired Olivia Dias, Sophia Brady, Lina Henriquez, and Zeynep Yalcin through the MIT Undergraduate Research Opportunity Program (UROP) and PRG hired freelancer Matt Taylor to work with Walker on developing the curriculum and designing interdisciplinary experience projects. Walker and the four undergraduate researchers constructed an intersectional data analysis activity about different examples of systemic oppression. PRG also hired three high school students to test activities and offer insights about making the curriculum engaging for program participants. Throughout the program, the Data Activism team taught students in small groups, continually asked students how to improve each activity, and structured each lesson based on the students’ interests. Walker says Dias, Brady, Henriquez, and Yalcin were invaluable to cultivating a supportive classroom environment and helping students complete their projects.

    Cambridge Rindge and Latin School senior Nina works on her rubber block stamp that depicts the importance of representation in media and greater representation in the tech industry.

    Photo: Katherine Ouellette

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    Student Nina says, “It’s opened my eyes to a different side of STEM. I didn’t know what ‘data’ meant before this program, or how intersectionality can affect AI and data.” Before MSYEP, Nina took Intro to Computer Science and AP Computer Science, but she has been coding since Girls Who Code first sparked her interest in middle school. “The community was really nice. I could talk with other girls. I saw there needs to be more women in STEM, especially in coding.” Now she’s interested in applying to colleges with strong computer science programs so she can pursue a coding-related career.

    From MSYEP to the mayor’s office

    Mayor Sumbul Siddiqui visited the Data Activism learning site on Aug. 9, accompanied by Breazeal. A graduate of MSYEP herself, Siddiqui says, “Through hands-on learning through computer programming, Cambridge high school students have the unique opportunity to see themselves as data scientists. Students were able learn ways to combat discrimination that occurs through artificial intelligence.” In an Instagram post, Siddiqui also said, “I had a blast visiting the students and learning about their projects.”

    Students worked on an activity that asked them to envision how data science might be used to support marginalized communities. They transformed their answers into block-printed T-shirt designs, carving pictures of their hopes into rubber block stamps. Some students focused on the importance of data privacy, like Jacob T., who drew a birdcage to represent data stored and locked away by third party apps. He says, “I want to open that cage and restore my data to myself and see what can be done with it.”

    The subject of Cambridge Community Charter School student Jacob T.’s project was the importance of data privacy. For his T-shirt design, he drew a birdcage to represent data stored and locked away by third party apps. (From right to left:) Breazeal, Jacob T. Kiki, Raechel Walker, and Zeynep Yalcin.

    Photo: Katherine Ouellette

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    Many students wanted to see more representation in both the media they consume and across various professional fields. Nina talked about the importance of representation in media and how that could contribute to greater representation in the tech industry, while Kiki talked about encouraging more women to pursue STEM fields. Jesmin said, “I wanted to show that data science is accessible to everyone, no matter their origin or language you speak. I wrote ‘hello’ in Bangla, Arabic, and English, because I speak all three languages and they all resonate with me.”

    Student Jesmin (left) explains the concept of her T-shirt design to Mayor Siddiqui. She wants data science to be accessible to everyone, no matter their origin or language, so she drew a globe and wrote ‘hello’ in the three languages she speaks: Bangla, Arabic, and English.

    Photo: Katherine Ouellette

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    “Overall, I hope the students continue to use their data activism skills to re-envision a society that supports marginalized groups,” says Walker. “Moreover, I hope they are empowered to become data scientists and understand how their race can be a positive part of their identity.” More

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    A technique to improve both fairness and accuracy in artificial intelligence

    For workers who use machine-learning models to help them make decisions, knowing when to trust a model’s predictions is not always an easy task, especially since these models are often so complex that their inner workings remain a mystery.

    Users sometimes employ a technique, known as selective regression, in which the model estimates its confidence level for each prediction and will reject predictions when its confidence is too low. Then a human can examine those cases, gather additional information, and make a decision about each one manually.

    But while selective regression has been shown to improve the overall performance of a model, researchers at MIT and the MIT-IBM Watson AI Lab have discovered that the technique can have the opposite effect for underrepresented groups of people in a dataset. As the model’s confidence increases with selective regression, its chance of making the right prediction also increases, but this does not always happen for all subgroups.

    For instance, a model suggesting loan approvals might make fewer errors on average, but it may actually make more wrong predictions for Black or female applicants. One reason this can occur is due to the fact that the model’s confidence measure is trained using overrepresented groups and may not be accurate for these underrepresented groups.

    Once they had identified this problem, the MIT researchers developed two algorithms that can remedy the issue. Using real-world datasets, they show that the algorithms reduce performance disparities that had affected marginalized subgroups.

    “Ultimately, this is about being more intelligent about which samples you hand off to a human to deal with. Rather than just minimizing some broad error rate for the model, we want to make sure the error rate across groups is taken into account in a smart way,” says senior MIT author Greg Wornell, the Sumitomo Professor in Engineering in the Department of Electrical Engineering and Computer Science (EECS) who leads the Signals, Information, and Algorithms Laboratory in the Research Laboratory of Electronics (RLE) and is a member of the MIT-IBM Watson AI Lab.

    Joining Wornell on the paper are co-lead authors Abhin Shah, an EECS graduate student, and Yuheng Bu, a postdoc in RLE; as well as Joshua Ka-Wing Lee SM ’17, ScD ’21 and Subhro Das, Rameswar Panda, and Prasanna Sattigeri, research staff members at the MIT-IBM Watson AI Lab. The paper will be presented this month at the International Conference on Machine Learning.

    To predict or not to predict

    Regression is a technique that estimates the relationship between a dependent variable and independent variables. In machine learning, regression analysis is commonly used for prediction tasks, such as predicting the price of a home given its features (number of bedrooms, square footage, etc.) With selective regression, the machine-learning model can make one of two choices for each input — it can make a prediction or abstain from a prediction if it doesn’t have enough confidence in its decision.

    When the model abstains, it reduces the fraction of samples it is making predictions on, which is known as coverage. By only making predictions on inputs that it is highly confident about, the overall performance of the model should improve. But this can also amplify biases that exist in a dataset, which occur when the model does not have sufficient data from certain subgroups. This can lead to errors or bad predictions for underrepresented individuals.

    The MIT researchers aimed to ensure that, as the overall error rate for the model improves with selective regression, the performance for every subgroup also improves. They call this monotonic selective risk.

    “It was challenging to come up with the right notion of fairness for this particular problem. But by enforcing this criteria, monotonic selective risk, we can make sure the model performance is actually getting better across all subgroups when you reduce the coverage,” says Shah.

    Focus on fairness

    The team developed two neural network algorithms that impose this fairness criteria to solve the problem.

    One algorithm guarantees that the features the model uses to make predictions contain all information about the sensitive attributes in the dataset, such as race and sex, that is relevant to the target variable of interest. Sensitive attributes are features that may not be used for decisions, often due to laws or organizational policies. The second algorithm employs a calibration technique to ensure the model makes the same prediction for an input, regardless of whether any sensitive attributes are added to that input.

    The researchers tested these algorithms by applying them to real-world datasets that could be used in high-stakes decision making. One, an insurance dataset, is used to predict total annual medical expenses charged to patients using demographic statistics; another, a crime dataset, is used to predict the number of violent crimes in communities using socioeconomic information. Both datasets contain sensitive attributes for individuals.

    When they implemented their algorithms on top of a standard machine-learning method for selective regression, they were able to reduce disparities by achieving lower error rates for the minority subgroups in each dataset. Moreover, this was accomplished without significantly impacting the overall error rate.

    “We see that if we don’t impose certain constraints, in cases where the model is really confident, it could actually be making more errors, which could be very costly in some applications, like health care. So if we reverse the trend and make it more intuitive, we will catch a lot of these errors. A major goal of this work is to avoid errors going silently undetected,” Sattigeri says.

    The researchers plan to apply their solutions to other applications, such as predicting house prices, student GPA, or loan interest rate, to see if the algorithms need to be calibrated for those tasks, says Shah. They also want to explore techniques that use less sensitive information during the model training process to avoid privacy issues.

    And they hope to improve the confidence estimates in selective regression to prevent situations where the model’s confidence is low, but its prediction is correct. This could reduce the workload on humans and further streamline the decision-making process, Sattigeri says.

    This research was funded, in part, by the MIT-IBM Watson AI Lab and its member companies Boston Scientific, Samsung, and Wells Fargo, and by the National Science Foundation. More

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    Artificial intelligence predicts patients’ race from their medical images

    The miseducation of algorithms is a critical problem; when artificial intelligence mirrors unconscious thoughts, racism, and biases of the humans who generated these algorithms, it can lead to serious harm. Computer programs, for example, have wrongly flagged Black defendants as twice as likely to reoffend as someone who’s white. When an AI used cost as a proxy for health needs, it falsely named Black patients as healthier than equally sick white ones, as less money was spent on them. Even AI used to write a play relied on using harmful stereotypes for casting. 

    Removing sensitive features from the data seems like a viable tweak. But what happens when it’s not enough? 

    Examples of bias in natural language processing are boundless — but MIT scientists have investigated another important, largely underexplored modality: medical images. Using both private and public datasets, the team found that AI can accurately predict self-reported race of patients from medical images alone. Using imaging data of chest X-rays, limb X-rays, chest CT scans, and mammograms, the team trained a deep learning model to identify race as white, Black, or Asian — even though the images themselves contained no explicit mention of the patient’s race. This is a feat even the most seasoned physicians cannot do, and it’s not clear how the model was able to do this. 

    In an attempt to tease out and make sense of the enigmatic “how” of it all, the researchers ran a slew of experiments. To investigate possible mechanisms of race detection, they looked at variables like differences in anatomy, bone density, resolution of images — and many more, and the models still prevailed with high ability to detect race from chest X-rays. “These results were initially confusing, because the members of our research team could not come anywhere close to identifying a good proxy for this task,” says paper co-author Marzyeh Ghassemi, an assistant professor in the MIT Department of Electrical Engineering and Computer Science and the Institute for Medical Engineering and Science (IMES), who is an affiliate of the Computer Science and Artificial Intelligence Laboratory (CSAIL) and of the MIT Jameel Clinic. “Even when you filter medical images past where the images are recognizable as medical images at all, deep models maintain a very high performance. That is concerning because superhuman capacities are generally much more difficult to control, regulate, and prevent from harming people.”

    In a clinical setting, algorithms can help tell us whether a patient is a candidate for chemotherapy, dictate the triage of patients, or decide if a movement to the ICU is necessary. “We think that the algorithms are only looking at vital signs or laboratory tests, but it’s possible they’re also looking at your race, ethnicity, sex, whether you’re incarcerated or not — even if all of that information is hidden,” says paper co-author Leo Anthony Celi, principal research scientist in IMES at MIT and associate professor of medicine at Harvard Medical School. “Just because you have representation of different groups in your algorithms, that doesn’t guarantee it won’t perpetuate or magnify existing disparities and inequities. Feeding the algorithms with more data with representation is not a panacea. This paper should make us pause and truly reconsider whether we are ready to bring AI to the bedside.” 

    The study, “AI recognition of patient race in medical imaging: a modeling study,” was published in Lancet Digital Health on May 11. Celi and Ghassemi wrote the paper alongside 20 other authors in four countries.

    To set up the tests, the scientists first showed that the models were able to predict race across multiple imaging modalities, various datasets, and diverse clinical tasks, as well as across a range of academic centers and patient populations in the United States. They used three large chest X-ray datasets, and tested the model on an unseen subset of the dataset used to train the model and a completely different one. Next, they trained the racial identity detection models for non-chest X-ray images from multiple body locations, including digital radiography, mammography, lateral cervical spine radiographs, and chest CTs to see whether the model’s performance was limited to chest X-rays. 

    The team covered many bases in an attempt to explain the model’s behavior: differences in physical characteristics between different racial groups (body habitus, breast density), disease distribution (previous studies have shown that Black patients have a higher incidence for health issues like cardiac disease), location-specific or tissue specific differences, effects of societal bias and environmental stress, the ability of deep learning systems to detect race when multiple demographic and patient factors were combined, and if specific image regions contributed to recognizing race. 

    What emerged was truly staggering: The ability of the models to predict race from diagnostic labels alone was much lower than the chest X-ray image-based models. 

    For example, the bone density test used images where the thicker part of the bone appeared white, and the thinner part appeared more gray or translucent. Scientists assumed that since Black people generally have higher bone mineral density, the color differences helped the AI models to detect race. To cut that off, they clipped the images with a filter, so the model couldn’t color differences. It turned out that cutting off the color supply didn’t faze the model — it still could accurately predict races. (The “Area Under the Curve” value, meaning the measure of the accuracy of a quantitative diagnostic test, was 0.94–0.96). As such, the learned features of the model appeared to rely on all regions of the image, meaning that controlling this type of algorithmic behavior presents a messy, challenging problem. 

    The scientists acknowledge limited availability of racial identity labels, which caused them to focus on Asian, Black, and white populations, and that their ground truth was a self-reported detail. Other forthcoming work will include potentially looking at isolating different signals before image reconstruction, because, as with bone density experiments, they couldn’t account for residual bone tissue that was on the images. 

    Notably, other work by Ghassemi and Celi led by MIT student Hammaad Adam has found that models can also identify patient self-reported race from clinical notes even when those notes are stripped of explicit indicators of race. Just as in this work, human experts are not able to accurately predict patient race from the same redacted clinical notes.

    “We need to bring social scientists into the picture. Domain experts, which are usually the clinicians, public health practitioners, computer scientists, and engineers are not enough. Health care is a social-cultural problem just as much as it’s a medical problem. We need another group of experts to weigh in and to provide input and feedback on how we design, develop, deploy, and evaluate these algorithms,” says Celi. “We need to also ask the data scientists, before any exploration of the data, are there disparities? Which patient groups are marginalized? What are the drivers of those disparities? Is it access to care? Is it from the subjectivity of the care providers? If we don’t understand that, we won’t have a chance of being able to identify the unintended consequences of the algorithms, and there’s no way we’ll be able to safeguard the algorithms from perpetuating biases.”

    “The fact that algorithms ‘see’ race, as the authors convincingly document, can be dangerous. But an important and related fact is that, when used carefully, algorithms can also work to counter bias,” says Ziad Obermeyer, associate professor at the University of California at Berkeley, whose research focuses on AI applied to health. “In our own work, led by computer scientist Emma Pierson at Cornell, we show that algorithms that learn from patients’ pain experiences can find new sources of knee pain in X-rays that disproportionately affect Black patients — and are disproportionately missed by radiologists. So just like any tool, algorithms can be a force for evil or a force for good — which one depends on us, and the choices we make when we build algorithms.”

    The work is supported, in part, by the National Institutes of Health. More