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      Helping the cause of environmental resilience

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      Haruko Wainwright, the Norman C. Rasmussen Career Development Professor in Nuclear Science and Engineering (NSE) and assistant professor in civil and environmental engineering at MIT, grew up in rural Japan, where many nuclear facilities are located. She remembers worrying about the facilities as a child. Wainwright was only 6 at the time of the Chernobyl accident in 1986, but still recollects it vividly.

      Those early memories have contributed to Wainwright’s determination to research how technologies can mold environmental resilience — the capability of mitigating the consequences of accidents and recovering from contamination.

      Wainwright believes that environmental monitoring can help improve resilience. She co-leads the U.S. Department of Energy (DOE)’s Advanced Long-term Environmental Monitoring Systems (ALTEMIS) project, which integrates technologies such as in situ sensors, geophysics, remote sensing, simulations, and artificial intelligence to establish new paradigms for monitoring. The project focuses on soil and groundwater contamination at more than 100 U.S. sites that were used for nuclear weapons production.

      As part of this research, which was featured last year in Environmental Science & Technology Journal, Wainwright is working on a machine learning framework for improving environmental monitoring strategies. She hopes the ALTEMIS project will enable the rapid detection of anomalies while ensuring the stability of residual contamination and waste disposal facilities.

      Childhood in rural Japan

      Even as a child, Wainwright was interested in physics, history, and a variety of other subjects.

      But growing up in a rural area was not ideal for someone interested in STEM. There were no engineers or scientists in the community and no science museums, either. “It was not so cool to be interested in science, and I never talked about my interest with anyone,” Wainwright recalls.

      Television and books were the only door to the world of science. “I did not study English until middle school and I had never been on a plane until college. I sometimes find it miraculous that I am now working in the U.S. and teaching at MIT,” she says.

      As she grew a little older, Wainwright heard a lot of discussions about nuclear facilities in the region and many stories about Hiroshima and Nagasaki.

      At the same time, giants like Marie Curie inspired her to pursue science. Nuclear physics was particularly fascinating. “At some point during high school, I started wondering ‘what are radiations, what is radioactivity, what is light,’” she recalls. Reading Richard Feynman’s books and trying to understand quantum mechanics made her want to study physics in college.

      Pursuing research in the United States

      Wainwright pursued an undergraduate degree in engineering physics at Kyoto University. After two research internships in the United States, Wainwright was impressed by the dynamic and fast-paced research environment in the country.

      And compared to Japan, there were “more women in science and engineering,” Wainwright says. She enrolled at the University of California at Berkeley in 2005, where she completed her doctorate in nuclear engineering with minors in statistics and civil and environmental engineering.

      Before moving to MIT NSE in 2022, Wainwright was a staff scientist in the Earth and Environmental Area at Lawrence Berkeley National Laboratory (LBNL). She worked on a variety of topics, including radioactive contamination, climate science, CO2 sequestration, precision agriculture, and watershed science. Her time at LBNL helped Wainwright build a solid foundation about a variety of environmental sensors and monitoring and simulation methods across different earth science disciplines.   

      Empowering communities through monitoring

      One of the most compelling takeaways from Wainwright’s early research: People trust actual measurements and data as facts, even though they are skeptical about models and predictions. “I talked with many people living in Fukushima prefecture. Many of them have dosimeters and measure radiation levels on their own. They might not trust the government, but they trust their own data and are then convinced that it is safe to live there and to eat local food,” Wainwright says.

      She has been impressed that area citizens have gained significant knowledge about radiation and radioactivity through these efforts. “But they are often frustrated that people living far away, in cities like Tokyo, still avoid agricultural products from Fukushima,” Wainwright says.

      Wainwright thinks that data derived from environmental monitoring — through proper visualization and communication — can address misconceptions and fake news that often hurt people near contaminated sites.

      Wainwright is now interested in how these technologies — tested with real data at contaminated sites — can be proactively used for existing and future nuclear facilities “before contamination happens,” as she explored for Nuclear News. “I don’t think it is a good idea to simply dismiss someone’s concern as irrational. Showing credible data has been much more effective to provide assurance. Or a proper monitoring network would enable us to minimize contamination or support emergency responses when accidents happen,” she says.

      Educating communities and students

      Part of empowering communities involves improving their ability to process science-based information. “Potentially hazardous facilities always end up in rural regions; minorities’ concerns are often ignored. The problem is that these regions don’t produce so many scientists or policymakers; they don’t have a voice,” Wainwright says, “I am determined to dedicate my time to improve STEM education in rural regions and to increase the voice in these regions.”

      In a project funded by DOE, she collaborates with the team of researchers at the University of Alaska — the Alaska Center for Energy and Power and Teaching Through Technology program — aiming to improve STEM education for rural and indigenous communities. “Alaska is an important place for energy transition and environmental justice,” Wainwright says. Micro-nuclear reactors can potentially improve the life of rural communities who bear the brunt of the high cost of fuel and transportation. However, there is a distrust of nuclear technologies, stemming from past nuclear weapon testing. At the same time, Alaska has vast metal mining resources for renewable energy and batteries. And there are concerns about environmental contamination from mining and various sources. The teams’ vision is much broader, she points out. “The focus is on broader environmental monitoring technologies and relevant STEM education, addressing general water and air qualities,” Wainwright says.

      The issues also weave into the courses Wainwright teaches at MIT. “I think it is important for engineering students to be aware of environmental justice related to energy waste and mining as well as past contamination events and their recovery,” she says. “It is not OK just to send waste to, or develop mines in, rural regions, which could be a special place for some people. We need to make sure that these developments will not harm the environment and health of local communities.” Wainwright also hopes that this knowledge will ultimately encourage students to think creatively about engineering designs that minimize waste or recycle material.

      The last question of the final quiz of one of her recent courses was: Assume that you store high-level radioactive waste in your “backyard.” What technical strategies would make you and your family feel safe? “All students thought about this question seriously and many suggested excellent points, including those addressing environmental monitoring,” Wainwright says, “that made me hopeful about the future.” More

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      MIT community members elected to the National Academy of Engineering for 2023

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      Seven MIT researchers are among the 106 new members and 18 international members elected to the National Academy of Engineering (NAE) this week. Fourteen additional MIT alumni, including one member of the MIT Corporation, were also elected as new members.

      One of the highest professional distinctions for engineers, membership to the NAE is given to individuals who have made outstanding contributions to “engineering research, practice, or education, including, where appropriate, significant contributions to the engineering literature” and to “the pioneering of new and developing fields of technology, making major advancements in traditional fields of engineering, or developing/implementing innovative approaches to engineering education.”

      The seven MIT researchers elected this year include:

      Regina Barzilay, the School of Engineering Distinguished Professor for AI and Health in the Department of Electrical Engineering and Computer Science, principal investigator at the Computer Science and Artificial Intelligence Laboratory, and faculty lead for the MIT Abdul Latif Jameel Clinic for Machine Learning in Health, for machine learning models that understand structures in text, molecules, and medical images.

      Markus J. Buehler, the Jerry McAfee (1940) Professor in Engineering from the Department of Civil and Environmental Engineering, for implementing the use of nanomechanics to model and design fracture-resistant bioinspired materials.

      Elfatih A.B. Eltahir SM ’93, ScD ’93, the H.M. King Bhumibol Professor in the Department of Civil and Environmental Engineering, for advancing understanding of how climate and land use impact water availability, environmental and human health, and vector-borne diseases.

      Neil Gershenfeld, director of the Center for Bits and Atoms, for eliminating boundaries between digital and physical worlds, from quantum computing to digital materials to the internet of things.

      Roger D. Kamm SM ’73, PhD ’77, the Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering, for contributions to the understanding of mechanics in biology and medicine, and leadership in biomechanics.

      David W. Miller ’82, SM ’85, ScD ’88, the Jerome C. Hunsaker Professor in the Department of Aeronautics and Astronautics, for contributions in control technology for space-based telescope design, and leadership in cross-agency guidance of space technology.

      David Simchi-Levi, professor of civil and environmental engineering, core faculty member in the Institute for Data, Systems, and Society, and principal investigator at the Laboratory for Information and Decision Systems, for contributions using optimization and stochastic modeling to enhance supply chain management and operations.

      Fariborz Maseeh ScD ’90, life member of the MIT Corporation and member of the School of Engineering Dean’s Advisory Council, was also elected as a member for leadership and advances in efficient design, development, and manufacturing of microelectromechanical systems, and for empowering engineering talent through public service.

      Thirteen additional alumni were elected to the National Academy of Engineering this year. They are: Mark George Allen SM ’86, PhD ’89; Shorya Awtar ScD ’04; Inderjit Chopra ScD ’77; David Huang ’85, SM ’89, PhD ’93; Eva Lerner-Lam SM ’78; David F. Merrion SM ’59; Virginia Norwood ’47; Martin Gerard Plys ’80, SM ’81, ScD ’84; Mark Prausnitz PhD ’94; Anil Kumar Sachdev ScD ’77; Christopher Scholz PhD ’67; Melody Ann Swartz PhD ’98; and Elias Towe ’80, SM ’81, PhD ’87.

      “I am delighted that seven members of MIT’s faculty and many members of the wider MIT community were elected to the National Academy of Engineering this year,” says Anantha Chandrakasan, the dean of the MIT School of Engineering and the Vannevar Bush Professor of Electrical Engineering and Computer Science. “My warmest congratulations on this recognition of their many contributions to engineering research and education.”

      Including this year’s inductees, 156 members of the National Academy of Engineering are current or retired members of the MIT faculty and staff, or members of the MIT Corporation. More

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      Unpacking the “black box” to build better AI models

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      When deep learning models are deployed in the real world, perhaps to detect financial fraud from credit card activity or identify cancer in medical images, they are often able to outperform humans.

      But what exactly are these deep learning models learning? Does a model trained to spot skin cancer in clinical images, for example, actually learn the colors and textures of cancerous tissue, or is it flagging some other features or patterns?

      These powerful machine-learning models are typically based on artificial neural networks that can have millions of nodes that process data to make predictions. Due to their complexity, researchers often call these models “black boxes” because even the scientists who build them don’t understand everything that is going on under the hood.

      Stefanie Jegelka isn’t satisfied with that “black box” explanation. A newly tenured associate professor in the MIT Department of Electrical Engineering and Computer Science, Jegelka is digging deep into deep learning to understand what these models can learn and how they behave, and how to build certain prior information into these models.

      “At the end of the day, what a deep-learning model will learn depends on so many factors. But building an understanding that is relevant in practice will help us design better models, and also help us understand what is going on inside them so we know when we can deploy a model and when we can’t. That is critically important,” says Jegelka, who is also a member of the Computer Science and Artificial Intelligence Laboratory (CSAIL) and the Institute for Data, Systems, and Society (IDSS).

      Jegelka is particularly interested in optimizing machine-learning models when input data are in the form of graphs. Graph data pose specific challenges: For instance, information in the data consists of both information about individual nodes and edges, as well as the structure — what is connected to what. In addition, graphs have mathematical symmetries that need to be respected by the machine-learning model so that, for instance, the same graph always leads to the same prediction. Building such symmetries into a machine-learning model is usually not easy.

      Take molecules, for instance. Molecules can be represented as graphs, with vertices that correspond to atoms and edges that correspond to chemical bonds between them. Drug companies may want to use deep learning to rapidly predict the properties of many molecules, narrowing down the number they must physically test in the lab.

      Jegelka studies methods to build mathematical machine-learning models that can effectively take graph data as an input and output something else, in this case a prediction of a molecule’s chemical properties. This is particularly challenging since a molecule’s properties are determined not only by the atoms within it, but also by the connections between them.  

      Other examples of machine learning on graphs include traffic routing, chip design, and recommender systems.

      Designing these models is made even more difficult by the fact that data used to train them are often different from data the models see in practice. Perhaps the model was trained using small molecular graphs or traffic networks, but the graphs it sees once deployed are larger or more complex.

      In this case, what can researchers expect this model to learn, and will it still work in practice if the real-world data are different?

      “Your model is not going to be able to learn everything because of some hardness problems in computer science, but what you can learn and what you can’t learn depends on how you set the model up,” Jegelka says.

      She approaches this question by combining her passion for algorithms and discrete mathematics with her excitement for machine learning.

      From butterflies to bioinformatics

      Jegelka grew up in a small town in Germany and became interested in science when she was a high school student; a supportive teacher encouraged her to participate in an international science competition. She and her teammates from the U.S. and Singapore won an award for a website they created about butterflies, in three languages.

      “For our project, we took images of wings with a scanning electron microscope at a local university of applied sciences. I also got the opportunity to use a high-speed camera at Mercedes Benz — this camera usually filmed combustion engines — which I used to capture a slow-motion video of the movement of a butterfly’s wings. That was the first time I really got in touch with science and exploration,” she recalls.

      Intrigued by both biology and mathematics, Jegelka decided to study bioinformatics at the University of Tübingen and the University of Texas at Austin. She had a few opportunities to conduct research as an undergraduate, including an internship in computational neuroscience at Georgetown University, but wasn’t sure what career to follow.

      When she returned for her final year of college, Jegelka moved in with two roommates who were working as research assistants at the Max Planck Institute in Tübingen.

      “They were working on machine learning, and that sounded really cool to me. I had to write my bachelor’s thesis, so I asked at the institute if they had a project for me. I started working on machine learning at the Max Planck Institute and I loved it. I learned so much there, and it was a great place for research,” she says.

      She stayed on at the Max Planck Institute to complete a master’s thesis, and then embarked on a PhD in machine learning at the Max Planck Institute and the Swiss Federal Institute of Technology.

      During her PhD, she explored how concepts from discrete mathematics can help improve machine-learning techniques.

      Teaching models to learn

      The more Jegelka learned about machine learning, the more intrigued she became by the challenges of understanding how models behave, and how to steer this behavior.

      “You can do so much with machine learning, but only if you have the right model and data. It is not just a black-box thing where you throw it at the data and it works. You actually have to think about it, its properties, and what you want the model to learn and do,” she says.

      After completing a postdoc at the University of California at Berkeley, Jegelka was hooked on research and decided to pursue a career in academia. She joined the faculty at MIT in 2015 as an assistant professor.

      “What I really loved about MIT, from the very beginning, was that the people really care deeply about research and creativity. That is what I appreciate the most about MIT. The people here really value originality and depth in research,” she says.

      That focus on creativity has enabled Jegelka to explore a broad range of topics.

      In collaboration with other faculty at MIT, she studies machine-learning applications in biology, imaging, computer vision, and materials science.

      But what really drives Jegelka is probing the fundamentals of machine learning, and most recently, the issue of robustness. Often, a model performs well on training data, but its performance deteriorates when it is deployed on slightly different data. Building prior knowledge into a model can make it more reliable, but understanding what information the model needs to be successful and how to build it in is not so simple, she says.

      She is also exploring methods to improve the performance of machine-learning models for image classification.

      Image classification models are everywhere, from the facial recognition systems on mobile phones to tools that identify fake accounts on social media. These models need massive amounts of data for training, but since it is expensive for humans to hand-label millions of images, researchers often use unlabeled datasets to pretrain models instead.

      These models then reuse the representations they have learned when they are fine-tuned later for a specific task.

      Ideally, researchers want the model to learn as much as it can during pretraining, so it can apply that knowledge to its downstream task. But in practice, these models often learn only a few simple correlations — like that one image has sunshine and one has shade — and use these “shortcuts” to classify images.

      “We showed that this is a problem in ‘contrastive learning,’ which is a standard technique for pre-training, both theoretically and empirically. But we also show that you can influence the kinds of information the model will learn to represent by modifying the types of data you show the model. This is one step toward understanding what models are actually going to do in practice,” she says.

      Researchers still don’t understand everything that goes on inside a deep-learning model, or details about how they can influence what a model learns and how it behaves, but Jegelka looks forward to continue exploring these topics.

      “Often in machine learning, we see something happen in practice and we try to understand it theoretically. This is a huge challenge. You want to build an understanding that matches what you see in practice, so that you can do better. We are still just at the beginning of understanding this,” she says.

      Outside the lab, Jegelka is a fan of music, art, traveling, and cycling. But these days, she enjoys spending most of her free time with her preschool-aged daughter. More

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      Urbanization: No fast lane to transformation

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      Accra, Ghana, “is a city I’ve come to know as well as any place in the U.S,” says Associate Professor Noah Nathan, who has conducted research there over the past 15 years. The booming capital of 4 million is an ideal laboratory for investigating the rapid urbanization of nations in Africa and beyond, believes Nathan, who joined the MIT Department of Political Science in July.

      “Accra is vibrant and exciting, with gleaming glass office buildings, shopping centers, and an emerging middle class,” he says. “But at the same time there is enormous poverty, with slums and a mixing pot of ethnic groups.” Cities like Accra that have emerged in developing countries around the world are “hybrid spaces” that provoke a multitude of questions for Nathan.

      “Rich and poor are in incredibly close proximity and I want to know how this dramatic inequality can be sustainable, and what politics looks like with such ethnic and class diversity living side-by-side,” he says.

      With his singular approach to data collection and deep understanding of Accra, its neighborhoods, and increasingly, its built environment, Nathan is generating a body of scholarship on the political impacts of urbanization throughout the global South.

      A trap in the urban transition

      Nathan’s early studies of Accra challenged common expectations about how urbanization shifts political behavior.

      “Modernization theory states that as people become more ‘modern’ and move to cities, ethnicity fades and class becomes the dominant dynamic in political behavior,” explains Nathan. “It predicts that the process of urbanization transforms the relationship between politicians and voters, and elections become more ideologically and policy oriented,” says Nathan.  

      But in Accra, the heart of one of the fastest-growing economies in the developing world, Nathan found “a type of politics stuck in an old equilibrium, hard to dislodge, and not updated by newly wealthy voters,” he says. Using census data revealing the demographic composition of every neighborhood in Accra, Nathan determined that there were many enclaves in which forms of patronage politics and ethnic competition persist. He conducted sample surveys and collected polling-station level results on residents’ voting across the city. “I was able to merge spatial data on where people lived and their answers to survey questions, and determine how different neighborhoods voted,” says Nathan.

      Among his findings: Ethnic politics were thriving in many parts of Accra, and many middle-class voters were withdrawing from politics entirely in reaction to the well-established practice of patronage rather than pressuring politicians to change their approach. “They decided it was better to look out for themselves,” he explains.

      In Nathan’s 2019 book, “Electoral Politics and Africa’s Urban Transition: Class and Ethnicity in Ghana,” he described this situation as a trap. “As the wealthy exit from the state, politicians double down on patronage politics with poor voters, which the middle class views as further evidence of corruption,” he explains. The wealthier citizens “want more public goods, and big policy reforms, such as changes in the health-care and tax systems, while poor voters focus on immediate needs such as jobs, homes, better schools in their communities.”

      In Ghana and other developing countries where the state’s capacity is limited, politicians can’t deliver on the broad-scale changes desired by the middle class. Motivated by their own political survival, they continue dealing with poor voters as clients, trading services for votes. “I connect urban politics in Ghana to the early 20th-century urban machines in the United States, run by party bosses,” says Nathan.

      This may prove sobering news for many engaged with the developing world. “There’s enormous enthusiasm among foreign aid organizations, in the popular press and policy circles, for the idea that urbanization will usher in big, radical political change,” notes Nathan. “But these kinds of transformations will only come about with structural change such as civil service reforms and nonpartisan welfare programs that can push politicians beyond just delivering targeted services to poor voters.”

      Falling in love with Ghana

      For most of his youth, Nathan was a committed jazz saxophonist, toying with going professional. But he had long cultivated another fascination as well. “I was a huge fan of ‘The West Wing’ in middle school” and got into American politics through that,” he says. He volunteered in Hillary Clinton’s 2008 primary campaign during college, but soon realized work in politics was “both more boring and not as idealistic” as he’d hoped.

      As an undergraduate at Harvard University, where he concentrated in government, he “signed up for African history on a lark — because American high schools didn’t teach anything on the subject — and I loved it,” Nathan says. He took another African history course, and then found his way to classes taught by Harvard political scientist Robert H. Bates PhD ’69 that focused on the political economy of development, ethnic conflict, and state failure in Africa. In the summer before his senior year, he served as a research assistant for one of his professors in Ghana, and then stayed longer, hoping to map out a senior thesis on ethnic conflict.

      “Once I got to Ghana, I was fascinated by the place — the dynamism of this rapidly transforming society,” he recalls. “Growing up in the U.S., there are a lot of stereotypes about the developing world, and I quickly realized how much more complicated everything is.”

      These initial experiences living in Ghana shaped Nathan’s ideas for what became his doctoral dissertation at Harvard and first book on the ethnic and class dynamics driving the nation’s politics. His frequent return visits to that country sparked a wealth of research that built on and branched out from this work.

      One set of studies examines the historical development of Ghana’s rural north in its colonial and post-colonial periods, the center of ethnic conflict in the 1990s. These are communities “where the state delivers few resources, doesn’t seem to do much, yet figures as a central actor in people’s lives,” he says.

      Part of this region had been a German colony, and the other part was originally under British rule, and Nathan compared the political trajectories of these two areas, focusing on differences in early state efforts to impose new forms of local political leadership and gradually build a formal education system.

      “The colonial legacy in the British areas was elite families who came to dominate, entrenching themselves and creating political dynasties and economic inequality,” says Nathan. But similar ethnic groups exposed to different state policies in the original German colony were not riven with the same class inequalities, and enjoy better access to government services today. “This research is changing how we think about state weakness in the developing world, how we tend to see the emergence of inequality where societal elites come into power,” he says. The results of Nathan’s research will be published in a forthcoming book, “The Scarce State: Inequality and Political Power in the Hinterland.”

      Politics of built spaces

      At MIT, Nathan is pivoting to a fresh new framing for questions on urbanization. Wielding a public source map of cities around the world, he is scrutinizing the geometry of street grids in 1,000 of sub-Saharan Africa’s largest cities “to think about urban order,” he says. Digitizing historical street maps of African cities from the Library of Congress’s map collection, he can look at how these cities were built and evolved physically. “When cities emerge based on grids, rather than tangles, they are more legible to governments,” he says. “This means that it’s easier to find people, easier to govern, tax, repress, and politically mobilize them.”  

      Nathan has begun to demonstrate that in the post-colonial period, “cities that were built under authoritarian regimes tend to be most legible, with even low-capacity regimes trying to impose control and make them gridded.” Democratic governments, he says, “lead to more tangled and chaotic built environments, with people doing what they want.” He also draws comparisons to how state policies shaped urban growth in the United States, with local and federal governments exerting control over neighborhood development, leading to redlining and segregation in many cities.

      Nathan’s interests naturally pull him toward the MIT Governance Lab and Global Diversity Lab. “I’m hoping to dive into both,” he says. “One big attraction of the department is the really interesting research that’s being done on developing countries.”  He also plans to use the stature he has built over many years of research in Africa to help “open doors” to African researchers and students, who may not always get the same kind of access to institutions and data that he has had. “I’m hoping to build connections to researchers in the global South,” he says. More

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      Four from MIT receive NIH New Innovator Awards for 2022

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      The National Institutes of Health (NIH) has awarded grants to four MIT faculty members as part of its High-Risk, High-Reward Research program.

      The program supports unconventional approaches to challenges in biomedical, behavioral, and social sciences. Each year, NIH Director’s Awards are granted to program applicants who propose high-risk, high-impact research in areas relevant to the NIH’s mission. In doing so, the NIH encourages innovative proposals that, due to their inherent risk, might struggle in the traditional peer-review process.

      This year, Lindsay Case, Siniša Hrvatin, Deblina Sarkar, and Caroline Uhler have been chosen to receive the New Innovator Award, which funds exceptionally creative research from early-career investigators. The award, which was established in 2007, supports researchers who are within 10 years of their final degree or clinical residency and have not yet received a research project grant or equivalent NIH grant.

      Lindsay Case, the Irwin and Helen Sizer Department of Biology Career Development Professor and an extramural member of the Koch Institute for Integrative Cancer Research, uses biochemistry and cell biology to study the spatial organization of signal transduction. Her work focuses on understanding how signaling molecules assemble into compartments with unique biochemical and biophysical properties to enable cells to sense and respond to information in their environment. Earlier this year, Case was one of two MIT assistant professors named as Searle Scholars.

      Siniša Hrvatin, who joined the School of Science faculty this past winter, is an assistant professor in the Department of Biology and a core member at the Whitehead Institute for Biomedical Research. He studies how animals and cells enter, regulate, and survive states of dormancy such as torpor and hibernation, aiming to harness the potential of these states therapeutically.

      Deblina Sarkar is an assistant professor and AT&T Career Development Chair Professor at the MIT Media Lab​. Her research combines the interdisciplinary fields of nanoelectronics, applied physics, and biology to invent disruptive technologies for energy-efficient nanoelectronics and merge such next-generation technologies with living matter to create a new paradigm for life-machine symbiosis. Her high-risk, high-reward proposal received the rare perfect impact score of 10, which is the highest score awarded by NIH.

      Caroline Uhler is a professor in the Department of Electrical Engineering and Computer Science and the Institute for Data, Systems, and Society. In addition, she is a core institute member at the Broad Institute of MIT and Harvard, where she co-directs the Eric and Wendy Schmidt Center. By combining machine learning, statistics, and genomics, she develops representation learning and causal inference methods to elucidate gene regulation in health and disease.

      The High-Risk, High-Reward Research program is supported by the NIH Common Fund, which oversees programs that pursue major opportunities and gaps in biomedical research that require collaboration across NIH Institutes and Centers. In addition to the New Innovator Award, the NIH also issues three other awards each year: the Pioneer Award, which supports bold and innovative research projects with unusually broad scientific impact; the Transformative Research Award, which supports risky and untested projects with transformative potential; and the Early Independence Award, which allows especially impressive junior scientists to skip the traditional postdoctoral training program to launch independent research careers.

      This year, the High-Risk, High-Reward Research program is awarding 103 awards, including eight Pioneer Awards, 72 New Innovator Awards, nine Transformative Research Awards, and 14 Early Independence Awards. These 103 awards total approximately $285 million in support from the institutes, centers, and offices across NIH over five years. “The science advanced by these researchers is poised to blaze new paths of discovery in human health,” says Lawrence A. Tabak DDS, PhD, who is performing the duties of the director of NIH. “This unique cohort of scientists will transform what is known in the biological and behavioral world. We are privileged to support this innovative science.” More

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      Investigating at the interface of data science and computing

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      A visual model of Guy Bresler’s research would probably look something like a Venn diagram. He works at the four-way intersection where theoretical computer science, statistics, probability, and information theory collide.

      “There are always new things to do be done at the interface. There are always opportunities for entirely new questions to ask,” says Bresler, an associate professor who recently earned tenure in MIT’s Department of Electrical Engineering and Computer Science (EECS).

      A theoretician, he aims to understand the delicate interplay between structure in data, the complexity of models, and the amount of computation needed to learn those models. Recently, his biggest focus has been trying to unveil fundamental phenomena that are broadly responsible for determining the computational complexity of statistics problems — and finding the “sweet spot” where available data and computation resources enable researchers to effectively solve a problem.

      When trying to solve a complex statistics problem, there is often a tug-of-war between data and computation. Without enough data, the computation needed to solve a statistical problem can be intractable, or at least consume a staggering amount of resources. But get just enough data and suddenly the intractable becomes solvable; the amount of computation needed to come up with a solution drops dramatically.

      The majority of modern statistical problems exhibits this sort of trade-off between computation and data, with applications ranging from drug development to weather prediction. Another well-studied and practically important example is cryo-electron microscopy, Bresler says. With this technique, researchers use an electron microscope to take images of molecules in different orientations. The central challenge is how to solve the inverse problem — determining the molecule’s structure given the noisy data. Many statistical problems can be formulated as inverse problems of this sort.

      One aim of Bresler’s work is to elucidate relationships between the wide variety of different statistics problems currently being studied. The dream is to classify statistical problems into equivalence classes, as has been done for other types of computational problems in the field of computational complexity. Showing these sorts of relationships means that, instead of trying to understand each problem in isolation, researchers can transfer their understanding from a well-studied problem to a poorly understood one, he says.

      Adopting a theoretical approach

      For Bresler, a desire to theoretically understand various basic phenomena inspired him to follow a path into academia.

      Both of his parents worked as professors and showed how fulfilling academia can be, he says. His earliest introduction to the theoretical side of engineering came from his father, who is an electrical engineer and theoretician studying signal processing. Bresler was inspired by his work from an early age. As an undergraduate at the University of Illinois at Urbana-Champaign, he bounced between physics, math, and computer science courses. But no matter the topic, he gravitated toward the theoretical viewpoint.

      In graduate school at the University of California at Berkeley, Bresler enjoyed the opportunity to work in a wide variety of topics spanning probability, theoretical computer science, and mathematics. His driving motivator was a love of learning new things.

      “Working at the interface of multiple fields with new questions, there is a feeling that one had better learn as much as possible if one is to have any chance of finding the right tools to answer those questions,” he says.

      That curiosity led him to MIT for a postdoc in the Laboratory for Information and Decision Systems (LIDS) in 2013, and then he joined the faculty two years later as an assistant professor in EECS. He was named an associate professor in 2019.

      Bresler says he was drawn to the intellectual atmosphere at MIT, as well as the supportive environment for launching bold research quests and trying to make progress in new areas of study.

      Opportunities for collaboration

      “What really struck me was how vibrant and energetic and collaborative MIT is. I have this mental list of more than 20 people here who I would love to have lunch with every single week and collaborate with on research. So just based on sheer numbers, joining MIT was a clear win,” he says.

      He’s especially enjoyed collaborating with his students, who continually teach him new things and ask deep questions that drive exciting research projects. One such student, Matthew Brennan, who was one of Bresler’s closest collaborators, tragically and unexpectedly passed away in January, 2021.

      The shock from Brennan’s death is still raw for Bresler, and it derailed his research for a time.

      “Beyond his own prodigious capabilities and creativity, he had this amazing ability to listen to an idea of mine that was almost completely wrong, extract from it a useful piece, and then pass the ball back,” he says. “We had the same vision for what we wanted to achieve in the work, and we were driven to try to tell a certain story. At the time, almost nobody was pursuing this particular line of work, and it was in a way kind of lonely. But he trusted me, and we encouraged one another to keep at it when things seemed bleak.”

      Those lessons in perseverance fuel Bresler as he and his students continue exploring questions that, by their nature, are difficult to answer.

      One area he’s worked in on-and-off for over a decade involves learning graphical models from data. Models of certain types of data, such as time-series data consisting of temperature readings, are often constructed by domain experts who have relevant knowledge and can build a reasonable model, he explains.

      But for many types of data with complex dependencies, such as social network or biological data, it is not at all clear what structure a model should take. Bresler’s work seeks to estimate a structured model from data, which could then be used for downstream applications like making recommendations or better predicting the weather.

      The basic question of identifying good models, whether algorithmically in a complex setting or analytically, by specifying a useful toy model for theoretical analysis, connects the abstract work with engineering practice, he says.

      “In general, modeling is an art. Real life is complicated and if you write down some super-complicated model that tries to capture every feature of a problem, it is doomed,” says Bresler. “You have to think about the problem and understand the practical side of things on some level to identify the correct features of the problem to be modeled, so that you can hope to actually solve it and gain insight into what one should do in practice.”

      Outside the lab, Bresler often finds himself solving very different kinds of problems. He is an avid rock climber and spends much of his free time bouldering throughout New England.

      “I really love it. It is a good excuse to get outside and get sucked into a whole different world. Even though there is problem solving involved, and there are similarities at the philosophical level, it is totally orthogonal to sitting down and doing math,” he says. More

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      Q&A: Global challenges surrounding the deployment of AI

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      The AI Policy Forum (AIPF) is an initiative of the MIT Schwarzman College of Computing to move the global conversation about the impact of artificial intelligence from principles to practical policy implementation. Formed in late 2020, AIPF brings together leaders in government, business, and academia to develop approaches to address the societal challenges posed by the rapid advances and increasing applicability of AI.

      The co-chairs of the AI Policy Forum are Aleksander Madry, the Cadence Design Systems Professor; Asu Ozdaglar, deputy dean of academics for the MIT Schwarzman College of Computing and head of the Department of Electrical Engineering and Computer Science; and Luis Videgaray, senior lecturer at MIT Sloan School of Management and director of MIT AI Policy for the World Project. Here, they discuss talk some of the key issues facing the AI policy landscape today and the challenges surrounding the deployment of AI. The three are co-organizers of the upcoming AI Policy Forum Summit on Sept. 28, which will further explore the issues discussed here.

      Q: Can you talk about the ­ongoing work of the AI Policy Forum and the AI policy landscape generally?

      Ozdaglar: There is no shortage of discussion about AI at different venues, but conversations are often high-level, focused on questions of ethics and principles, or on policy problems alone. The approach the AIPF takes to its work is to target specific questions with actionable policy solutions and engage with the stakeholders working directly in these areas. We work “behind the scenes” with smaller focus groups to tackle these challenges and aim to bring visibility to some potential solutions alongside the players working directly on them through larger gatherings.

      Q: AI impacts many sectors, which makes us naturally worry about its trustworthiness. Are there any emerging best practices for development and deployment of trustworthy AI?

      Madry: The most important thing to understand regarding deploying trustworthy AI is that AI technology isn’t some natural, preordained phenomenon. It is something built by people. People who are making certain design decisions.

      We thus need to advance research that can guide these decisions as well as provide more desirable solutions. But we also need to be deliberate and think carefully about the incentives that drive these decisions. 

      Now, these incentives stem largely from the business considerations, but not exclusively so. That is, we should also recognize that proper laws and regulations, as well as establishing thoughtful industry standards have a big role to play here too.

      Indeed, governments can put in place rules that prioritize the value of deploying AI while being keenly aware of the corresponding downsides, pitfalls, and impossibilities. The design of such rules will be an ongoing and evolving process as the technology continues to improve and change, and we need to adapt to socio-political realities as well.

      Q: Perhaps one of the most rapidly evolving domains in AI deployment is in the financial sector. From a policy perspective, how should governments, regulators, and lawmakers make AI work best for consumers in finance?

      Videgaray: The financial sector is seeing a number of trends that present policy challenges at the intersection of AI systems. For one, there is the issue of explainability. By law (in the U.S. and in many other countries), lenders need to provide explanations to customers when they take actions deleterious in whatever way, like denial of a loan, to a customer’s interest. However, as financial services increasingly rely on automated systems and machine learning models, the capacity of banks to unpack the “black box” of machine learning to provide that level of mandated explanation becomes tenuous. So how should the finance industry and its regulators adapt to this advance in technology? Perhaps we need new standards and expectations, as well as tools to meet these legal requirements.

      Meanwhile, economies of scale and data network effects are leading to a proliferation of AI outsourcing, and more broadly, AI-as-a-service is becoming increasingly common in the finance industry. In particular, we are seeing fintech companies provide the tools for underwriting to other financial institutions — be it large banks or small, local credit unions. What does this segmentation of the supply chain mean for the industry? Who is accountable for the potential problems in AI systems deployed through several layers of outsourcing? How can regulators adapt to guarantee their mandates of financial stability, fairness, and other societal standards?

      Q: Social media is one of the most controversial sectors of the economy, resulting in many societal shifts and disruptions around the world. What policies or reforms might be needed to best ensure social media is a force for public good and not public harm?

      Ozdaglar: The role of social media in society is of growing concern to many, but the nature of these concerns can vary quite a bit — with some seeing social media as not doing enough to prevent, for example, misinformation and extremism, and others seeing it as unduly silencing certain viewpoints. This lack of unified view on what the problem is impacts the capacity to enact any change. All of that is additionally coupled with the complexities of the legal framework in the U.S. spanning the First Amendment, Section 230 of the Communications Decency Act, and trade laws.

      However, these difficulties in regulating social media do not mean that there is nothing to be done. Indeed, regulators have begun to tighten their control over social media companies, both in the United States and abroad, be it through antitrust procedures or other means. In particular, Ofcom in the U.K. and the European Union is already introducing new layers of oversight to platforms. Additionally, some have proposed taxes on online advertising to address the negative externalities caused by current social media business model. So, the policy tools are there, if the political will and proper guidance exists to implement them. More

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      Computing for the health of the planet

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      The health of the planet is one of the most important challenges facing humankind today. From climate change to unsafe levels of air and water pollution to coastal and agricultural land erosion, a number of serious challenges threaten human and ecosystem health.

      Ensuring the health and safety of our planet necessitates approaches that connect scientific, engineering, social, economic, and political aspects. New computational methods can play a critical role by providing data-driven models and solutions for cleaner air, usable water, resilient food, efficient transportation systems, better-preserved biodiversity, and sustainable sources of energy.

      The MIT Schwarzman College of Computing is committed to hiring multiple new faculty in computing for climate and the environment, as part of MIT’s plan to recruit 20 climate-focused faculty under its climate action plan. This year the college undertook searches with several departments in the schools of Engineering and Science for shared faculty in computing for health of the planet, one of the six strategic areas of inquiry identified in an MIT-wide planning process to help focus shared hiring efforts. The college also undertook searches for core computing faculty in the Department of Electrical Engineering and Computer Science (EECS).

      The searches are part of an ongoing effort by the MIT Schwarzman College of Computing to hire 50 new faculty — 25 shared with other academic departments and 25 in computer science and artificial intelligence and decision-making. The goal is to build capacity at MIT to help more deeply infuse computing and other disciplines in departments.

      Four interdisciplinary scholars were hired in these searches. They will join the MIT faculty in the coming year to engage in research and teaching that will advance physical understanding of low-carbon energy solutions, Earth-climate modeling, biodiversity monitoring and conservation, and agricultural management through high-performance computing, transformational numerical methods, and machine-learning techniques.

      “By coordinating hiring efforts with multiple departments and schools, we were able to attract a cohort of exceptional scholars in this area to MIT. Each of them is developing and using advanced computational methods and tools to help find solutions for a range of climate and environmental issues,” says Daniel Huttenlocher, dean of the MIT Schwarzman College of Computing and the Henry Warren Ellis Professor of Electrical Engineering and Computer Science. “They will also help strengthen cross-departmental ties in computing across an important, critical area for MIT and the world.”

      “These strategic hires in the area of computing for climate and the environment are an incredible opportunity for the college to deepen its academic offerings and create new opportunity for collaboration across MIT,” says Anantha P. Chandrakasan, dean of the MIT School of Engineering and the Vannevar Bush Professor of Electrical Engineering and Computer Science. “The college plays a pivotal role in MIT’s overarching effort to hire climate-focused faculty — introducing the critical role of computing to address the health of the planet through innovative research and curriculum.”

      The four new faculty members are:

      Sara Beery will join MIT as an assistant professor in the Faculty of Artificial Intelligence and Decision-Making in EECS in September 2023. Beery received her PhD in computing and mathematical sciences at Caltech in 2022, where she was advised by Pietro Perona. Her research focuses on building computer vision methods that enable global-scale environmental and biodiversity monitoring across data modalities, tackling real-world challenges including strong spatiotemporal correlations, imperfect data quality, fine-grained categories, and long-tailed distributions. She partners with nongovernmental organizations and government agencies to deploy her methods in the wild worldwide and works toward increasing the diversity and accessibility of academic research in artificial intelligence through interdisciplinary capacity building and education.

      Priya Donti will join MIT as an assistant professor in the faculties of Electrical Engineering and Artificial Intelligence and Decision-Making in EECS in academic year 2023-24. Donti recently finished her PhD in the Computer Science Department and the Department of Engineering and Public Policy at Carnegie Mellon University, co-advised by Zico Kolter and Inês Azevedo. Her work focuses on machine learning for forecasting, optimization, and control in high-renewables power grids. Specifically, her research explores methods to incorporate the physics and hard constraints associated with electric power systems into deep learning models. Donti is also co-founder and chair of Climate Change AI, a nonprofit initiative to catalyze impactful work at the intersection of climate change and machine learning that is currently running through the Cornell Tech Runway Startup Postdoc Program.

      Ericmoore Jossou will join MIT as an assistant professor in a shared position between the Department of Nuclear Science and Engineering and the faculty of electrical engineering in EECS in July 2023. He is currently an assistant scientist at the Brookhaven National Laboratory, a U.S. Department of Energy-affiliated lab that conducts research in nuclear and high energy physics, energy science and technology, environmental and bioscience, nanoscience, and national security. His research at MIT will focus on understanding the processing-structure-properties correlation of materials for nuclear energy applications through advanced experiments, multiscale simulations, and data science. Jossou obtained his PhD in mechanical engineering in 2019 from the University of Saskatchewan.

      Sherrie Wang will join MIT as an assistant professor in a shared position between the Department of Mechanical Engineering and the Institute for Data, Systems, and Society in academic year 2023-24. Wang is currently a Ciriacy-Wantrup Postdoctoral Fellow at the University of California at Berkeley, hosted by Solomon Hsiang and the Global Policy Lab. She develops machine learning for Earth observation data. Her primary application areas are improving agricultural management and forecasting climate phenomena. She obtained her PhD in computational and mathematical engineering from Stanford University in 2021, where she was advised by David Lobell. More