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      MIT Faculty Founder Initiative announces three winners of entrepreneurship awards

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      Patients with intractable cancers, chronic pain sufferers, and people who depend on battery-powered medical implants may all benefit from the ideas presented at the 2023-24 MIT-Royalty Pharma Prize Competition’s recent awards. This year’s top prizes went to researchers and biotech entrepreneurs Anne Carpenter, Frederike Petzschner, and Betar Gallant ’08, SM ’10, PhD ’13.MIT Faculty Founder Initiative Executive Director Kit Hickey MBA ’13 describes the time and hard work the three awardees and other finalists devoted to the initiative and its mission of cultivating female faculty in biotech to cross the chasm between laboratory research and its clinical application.“They have taken the first brave step of getting off the bench when they already work seven days a week. They have carved out time from their facilities, from their labs, from their lives in order to put themselves out there and leap into entrepreneurship,” Hickey says. “They’ve done it because they each want to see their innovations out in the world improving patients’ lives.”Carpenter, senior director of the Imaging Platform at the Broad Institute of MIT and Harvard, where she is also an institute scientist, won the competition’s $250,000 2023-24 MIT-Royalty Pharma Faculty Founder Prize Competition Grand Prize. Carpenter specializes in using microscopy imaging of cells and computational methods such as machine learning to accelerate the identification of chemical compounds with therapeutic potential to, for instance, shrink tumors. The identified compounds are then tested in biological assays that model the tumor ecosystem to see how the compounds would perform on actual tumors.Carpenter’s startup, SyzOnc, launched in April, a feat Carpenter associates with the assistance provided by the MIT Faculty Founder Initiative. Participants in the program receive mentorship, stipends, and advice from industry experts, as well as help with incorporating, assembling a management team, fundraising, and intellectual property strategy.“The program offered key insights and input at major decision points that gave us the momentum to open our doors,” Carpenter says, adding that participating “offered validation of our scientific ideas and business plan. That kind of credibility is really helpful to raising funding, particularly for those starting their first company.”Carpenter says she and her team will employ “the best biological and computational advancements to develop new therapies to fight tumors such as sarcoma, pancreatic cancer, and glioblastoma, which currently have dismal survival rates.”The MIT Faculty Founder Initiative was begun in 2020 by the School of Engineering and the Martin Trust Center for MIT Entrepreneurship, based on research findings by Sangeeta Bhatia, the Wilson Professor of Health Sciences and Technology, professor of electrical engineering and computer science, and faculty director of the MIT Faculty Founder Initiative; Susan Hockfield, MIT Corporation life member, MIT president emerita, and professor of neuroscience; and Nancy Hopkins, professor emerita of biology. An investigation they conducted showed that only about 9 percent of MIT’s 250 biotech startups were started by women, whereas women made up 22 percent of the faculty, as was presented in a 2021 MIT Faculty Newsletter.That data showed that “technologies from female labs were not getting out in the world, resulting in lost potential,” Hickey says.“The MIT Faculty Founder Initiative plays a pivotal role in MIT’s entrepreneurship ecosystem. It elevates visionary faculty working on solutions in biotech by providing them with critical mentorship and resources, ensuring these solutions can be rapidly scaled to market,” says Anantha Chandrakasan, MIT’s chief innovation and strategy officer, dean of engineering, and Vannevar Bush Professor of Electrical Engineering and Computer Science.The MIT Faculty Founder Initiative Prize Competition was launched in 2021. At this year’s competition, the judges represented academia, health care, biotech, and financial investment. In addition to awarding a grand prize, the competition also distributed two $100,000 prizes, one to a researcher from Brown University, the first university to collaborate with MIT in the entrepreneurship program.This year’s winner of the $100,000 2023-24 MIT-Royalty Pharma Faculty Founder Prize Competition Runner-Up Prize was Frederike Petzschner, assistant professor at the Carney Institute for Brain Science at Brown, for her SOMA startup’s digital pain management system, which helps sufferers to manage and relieve chronic pain.“We leverage cutting-edge technology to provide precision care, focusing specifically on personalized cognitive interventions tailored to each patient’s unique needs,” she says.With her startup on the verge of incorporating, Petzschner says, “without the Faculty Finder Initiative, our startup would still be pursuing commercialization, but undoubtedly at a much earlier and perhaps less structured stage.”“The constant support from the program organizers and our mentors was truly transformative,” she says.Gallant, associate professor of mechanical engineering at MIT and winner of the $100,000 2023-24 MIT-Royalty Pharma Faculty Founder Prize Competition Breakthrough Prize, is leading the startup Halogen. An expert on advanced battery technologies, Gallant and her team have developed high-density battery storage to improve the lifetime and performance of such medical devices as pacemakers.“If you can extend lifetime, you’re talking about longer times between invasive replacement surgeries, which really affects patient quality of life,” Gallant told MIT News in a 2022 interview.Jim Reddoch, executive vice president and chief scientific officer of sponsor Royalty Pharma, emphasized his company’s support for both the competition and the MIT Faculty Finder Initiative program.“Royalty Pharma is thrilled to support the 2023-2024 MIT-Royalty Pharma Prize Competition and accelerate life sciences innovation at leading research institutions such as MIT and Brown,” Reddoch says. “By supporting the amazing female entrepreneurs in this program, we hope to catalyze more ideas from the lab to biotech companies and eventually into the hands of patients.”Bhatia has referred to the MIT Faculty Founder Initiative as a “playbook” on how to direct female faculty’s high-impact technologies that are not being commercialized into the world of health care.“To me, changing the game means that when you have an invention in your lab, you’re connected enough to the ecosystem to know when it should be a company, and to know who to call and how to get your first investors and how to quickly catalyze your team — and you’re off to the races,” Bhatia says. “Every one one of those inventions can be a medicine as quickly as possible. That’s the future I imagine.”Co-founder Hockfield referred to MIT’s role in promoting entrepreneurship in remarks at the award ceremony, alluding to Brown University’s having joined the effort.“MIT has always been a leader in entrepreneurship,” Hockfield says. “Part of leading is sharing with the world. The collaboration with Brown University for this cohort shows that MIT can share our approach with the world, allowing other universities to follow our model of supporting academic entrepreneurship.”Hickey says that when she and Bhatia asked 30 female faculty members three years ago why they were not commercializing their technologies, many said they had no access to the appropriate networks of mentors, investors, role models, and business partners necessary to begin the journey.“We encourage you to become this network that has been missing,” Hickey told the awards event audience, which included an array of leaders in the biotech world. “Get to know our amazing faculty members and continue to support them. Become a part of this movement.” More

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      A data-driven approach to making better choices

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      Imagine a world in which some important decision — a judge’s sentencing recommendation, a child’s treatment protocol, which person or business should receive a loan — was made more reliable because a well-designed algorithm helped a key decision-maker arrive at a better choice. A new MIT economics course is investigating these interesting possibilities.Class 14.163 (Algorithms and Behavioral Science) is a new cross-disciplinary course focused on behavioral economics, which studies the cognitive capacities and limitations of human beings. The course was co-taught this past spring by assistant professor of economics Ashesh Rambachan and visiting lecturer Sendhil Mullainathan.Rambachan studies the economic applications of machine learning, focusing on algorithmic tools that drive decision-making in the criminal justice system and consumer lending markets. He also develops methods for determining causation using cross-sectional and dynamic data.Mullainathan will soon join the MIT departments of Electrical Engineering and Computer Science and Economics as a professor. His research uses machine learning to understand complex problems in human behavior, social policy, and medicine. Mullainathan co-founded the Abdul Latif Jameel Poverty Action Lab (J-PAL) in 2003.The new course’s goals are both scientific (to understand people) and policy-driven (to improve society by improving decisions). Rambachan believes that machine-learning algorithms provide new tools for both the scientific and applied goals of behavioral economics.“The course investigates the deployment of computer science, artificial intelligence (AI), economics, and machine learning in service of improved outcomes and reduced instances of bias in decision-making,” Rambachan says.There are opportunities, Rambachan believes, for constantly evolving digital tools like AI, machine learning, and large language models (LLMs) to help reshape everything from discriminatory practices in criminal sentencing to health-care outcomes among underserved populations.Students learn how to use machine learning tools with three main objectives: to understand what they do and how they do it, to formalize behavioral economics insights so they compose well within machine learning tools, and to understand areas and topics where the integration of behavioral economics and algorithmic tools might be most fruitful.Students also produce ideas, develop associated research, and see the bigger picture. They’re led to understand where an insight fits and see where the broader research agenda is leading. Participants can think critically about what supervised LLMs can (and cannot) do, to understand how to integrate those capacities with the models and insights of behavioral economics, and to recognize the most fruitful areas for the application of what investigations uncover.The dangers of subjectivity and biasAccording to Rambachan, behavioral economics acknowledges that biases and mistakes exist throughout our choices, even absent algorithms. “The data used by our algorithms exist outside computer science and machine learning, and instead are often produced by people,” he continues. “Understanding behavioral economics is therefore essential to understanding the effects of algorithms and how to better build them.”Rambachan sought to make the course accessible regardless of attendees’ academic backgrounds. The class included advanced degree students from a variety of disciplines.By offering students a cross-disciplinary, data-driven approach to investigating and discovering ways in which algorithms might improve problem-solving and decision-making, Rambachan hopes to build a foundation on which to redesign existing systems of jurisprudence, health care, consumer lending, and industry, to name a few areas.“Understanding how data are generated can help us understand bias,” Rambachan says. “We can ask questions about producing a better outcome than what currently exists.”Useful tools for re-imagining social operationsEconomics doctoral student Jimmy Lin was skeptical about the claims Rambachan and Mullainathan made when the class began, but changed his mind as the course continued.“Ashesh and Sendhil started with two provocative claims: The future of behavioral science research will not exist without AI, and the future of AI research will not exist without behavioral science,” Lin says. “Over the course of the semester, they deepened my understanding of both fields and walked us through numerous examples of how economics informed AI research and vice versa.”Lin, who’d previously done research in computational biology, praised the instructors’ emphasis on the importance of a “producer mindset,” thinking about the next decade of research rather than the previous decade. “That’s especially important in an area as interdisciplinary and fast-moving as the intersection of AI and economics — there isn’t an old established literature, so you’re forced to ask new questions, invent new methods, and create new bridges,” he says.The speed of change to which Lin alludes is a draw for him, too. “We’re seeing black-box AI methods facilitate breakthroughs in math, biology, physics, and other scientific disciplines,” Lin  says. “AI can change the way we approach intellectual discovery as researchers.”An interdisciplinary future for economics and social systemsStudying traditional economic tools and enhancing their value with AI may yield game-changing shifts in how institutions and organizations teach and empower leaders to make choices.“We’re learning to track shifts, to adjust frameworks and better understand how to deploy tools in service of a common language,” Rambachan says. “We must continually interrogate the intersection of human judgment, algorithms, AI, machine learning, and LLMs.”Lin enthusiastically recommended the course regardless of students’ backgrounds. “Anyone broadly interested in algorithms in society, applications of AI across academic disciplines, or AI as a paradigm for scientific discovery should take this class,” he says. “Every lecture felt like a goldmine of perspectives on research, novel application areas, and inspiration on how to produce new, exciting ideas.”The course, Rambachan says, argues that better-built algorithms can improve decision-making across disciplines. “By building connections between economics, computer science, and machine learning, perhaps we can automate the best of human choices to improve outcomes while minimizing or eliminating the worst,” he says.Lin remains excited about the course’s as-yet unexplored possibilities. “It’s a class that makes you excited about the future of research and your own role in it,” he says. 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      A technique for more effective multipurpose robots

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      Let’s say you want to train a robot so it understands how to use tools and can then quickly learn to make repairs around your house with a hammer, wrench, and screwdriver. To do that, you would need an enormous amount of data demonstrating tool use.Existing robotic datasets vary widely in modality — some include color images while others are composed of tactile imprints, for instance. Data could also be collected in different domains, like simulation or human demos. And each dataset may capture a unique task and environment.It is difficult to efficiently incorporate data from so many sources in one machine-learning model, so many methods use just one type of data to train a robot. But robots trained this way, with a relatively small amount of task-specific data, are often unable to perform new tasks in unfamiliar environments.In an effort to train better multipurpose robots, MIT researchers developed a technique to combine multiple sources of data across domains, modalities, and tasks using a type of generative AI known as diffusion models.They train a separate diffusion model to learn a strategy, or policy, for completing one task using one specific dataset. Then they combine the policies learned by the diffusion models into a general policy that enables a robot to perform multiple tasks in various settings.In simulations and real-world experiments, this training approach enabled a robot to perform multiple tool-use tasks and adapt to new tasks it did not see during training. The method, known as Policy Composition (PoCo), led to a 20 percent improvement in task performance when compared to baseline techniques.“Addressing heterogeneity in robotic datasets is like a chicken-egg problem. If we want to use a lot of data to train general robot policies, then we first need deployable robots to get all this data. I think that leveraging all the heterogeneous data available, similar to what researchers have done with ChatGPT, is an important step for the robotics field,” says Lirui Wang, an electrical engineering and computer science (EECS) graduate student and lead author of a paper on PoCo.     Wang’s coauthors include Jialiang Zhao, a mechanical engineering graduate student; Yilun Du, an EECS graduate student; Edward Adelson, the John and Dorothy Wilson Professor of Vision Science in the Department of Brain and Cognitive Sciences and a member of the Computer Science and Artificial Intelligence Laboratory (CSAIL); and senior author Russ Tedrake, the Toyota Professor of EECS, Aeronautics and Astronautics, and Mechanical Engineering, and a member of CSAIL. The research will be presented at the Robotics: Science and Systems Conference.Combining disparate datasetsA robotic policy is a machine-learning model that takes inputs and uses them to perform an action. One way to think about a policy is as a strategy. In the case of a robotic arm, that strategy might be a trajectory, or a series of poses that move the arm so it picks up a hammer and uses it to pound a nail.Datasets used to learn robotic policies are typically small and focused on one particular task and environment, like packing items into boxes in a warehouse.“Every single robotic warehouse is generating terabytes of data, but it only belongs to that specific robot installation working on those packages. It is not ideal if you want to use all of these data to train a general machine,” Wang says.The MIT researchers developed a technique that can take a series of smaller datasets, like those gathered from many robotic warehouses, learn separate policies from each one, and combine the policies in a way that enables a robot to generalize to many tasks.They represent each policy using a type of generative AI model known as a diffusion model. Diffusion models, often used for image generation, learn to create new data samples that resemble samples in a training dataset by iteratively refining their output.But rather than teaching a diffusion model to generate images, the researchers teach it to generate a trajectory for a robot. They do this by adding noise to the trajectories in a training dataset. The diffusion model gradually removes the noise and refines its output into a trajectory.This technique, known as Diffusion Policy, was previously introduced by researchers at MIT, Columbia University, and the Toyota Research Institute. PoCo builds off this Diffusion Policy work. The team trains each diffusion model with a different type of dataset, such as one with human video demonstrations and another gleaned from teleoperation of a robotic arm.Then the researchers perform a weighted combination of the individual policies learned by all the diffusion models, iteratively refining the output so the combined policy satisfies the objectives of each individual policy.Greater than the sum of its parts“One of the benefits of this approach is that we can combine policies to get the best of both worlds. For instance, a policy trained on real-world data might be able to achieve more dexterity, while a policy trained on simulation might be able to achieve more generalization,” Wang says.

      With policy composition, researchers are able to combine datasets from multiple sources so they can teach a robot to effectively use a wide range of tools, like a hammer, screwdriver, or this spatula.Image: Courtesy of the researchers

      Because the policies are trained separately, one could mix and match diffusion policies to achieve better results for a certain task. A user could also add data in a new modality or domain by training an additional Diffusion Policy with that dataset, rather than starting the entire process from scratch.

      The policy composition technique the researchers developed can be used to effectively teach a robot to use tools even when objects are placed around it to try and distract it from its task, as seen here.Image: Courtesy of the researchers

      The researchers tested PoCo in simulation and on real robotic arms that performed a variety of tools tasks, such as using a hammer to pound a nail and flipping an object with a spatula. PoCo led to a 20 percent improvement in task performance compared to baseline methods.“The striking thing was that when we finished tuning and visualized it, we can clearly see that the composed trajectory looks much better than either one of them individually,” Wang says.In the future, the researchers want to apply this technique to long-horizon tasks where a robot would pick up one tool, use it, then switch to another tool. They also want to incorporate larger robotics datasets to improve performance.“We will need all three kinds of data to succeed for robotics: internet data, simulation data, and real robot data. How to combine them effectively will be the million-dollar question. PoCo is a solid step on the right track,” says Jim Fan, senior research scientist at NVIDIA and leader of the AI Agents Initiative, who was not involved with this work.This research is funded, in part, by Amazon, the Singapore Defense Science and Technology Agency, the U.S. National Science Foundation, and the Toyota Research Institute. More

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      Looking for a specific action in a video? This AI-based method can find it for you

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      The internet is awash in instructional videos that can teach curious viewers everything from cooking the perfect pancake to performing a life-saving Heimlich maneuver.But pinpointing when and where a particular action happens in a long video can be tedious. To streamline the process, scientists are trying to teach computers to perform this task. Ideally, a user could just describe the action they’re looking for, and an AI model would skip to its location in the video.However, teaching machine-learning models to do this usually requires a great deal of expensive video data that have been painstakingly hand-labeled.A new, more efficient approach from researchers at MIT and the MIT-IBM Watson AI Lab trains a model to perform this task, known as spatio-temporal grounding, using only videos and their automatically generated transcripts.The researchers teach a model to understand an unlabeled video in two distinct ways: by looking at small details to figure out where objects are located (spatial information) and looking at the bigger picture to understand when the action occurs (temporal information).Compared to other AI approaches, their method more accurately identifies actions in longer videos with multiple activities. Interestingly, they found that simultaneously training on spatial and temporal information makes a model better at identifying each individually.In addition to streamlining online learning and virtual training processes, this technique could also be useful in health care settings by rapidly finding key moments in videos of diagnostic procedures, for example.“We disentangle the challenge of trying to encode spatial and temporal information all at once and instead think about it like two experts working on their own, which turns out to be a more explicit way to encode the information. Our model, which combines these two separate branches, leads to the best performance,” says Brian Chen, lead author of a paper on this technique.Chen, a 2023 graduate of Columbia University who conducted this research while a visiting student at the MIT-IBM Watson AI Lab, is joined on the paper by James Glass, senior research scientist, member of the MIT-IBM Watson AI Lab, and head of the Spoken Language Systems Group in the Computer Science and Artificial Intelligence Laboratory (CSAIL); Hilde Kuehne, a member of the MIT-IBM Watson AI Lab who is also affiliated with Goethe University Frankfurt; and others at MIT, Goethe University, the MIT-IBM Watson AI Lab, and Quality Match GmbH. The research will be presented at the Conference on Computer Vision and Pattern Recognition.Global and local learningResearchers usually teach models to perform spatio-temporal grounding using videos in which humans have annotated the start and end times of particular tasks.Not only is generating these data expensive, but it can be difficult for humans to figure out exactly what to label. If the action is “cooking a pancake,” does that action start when the chef begins mixing the batter or when she pours it into the pan?“This time, the task may be about cooking, but next time, it might be about fixing a car. There are so many different domains for people to annotate. But if we can learn everything without labels, it is a more general solution,” Chen says.For their approach, the researchers use unlabeled instructional videos and accompanying text transcripts from a website like YouTube as training data. These don’t need any special preparation.They split the training process into two pieces. For one, they teach a machine-learning model to look at the entire video to understand what actions happen at certain times. This high-level information is called a global representation.For the second, they teach the model to focus on a specific region in parts of the video where action is happening. In a large kitchen, for instance, the model might only need to focus on the wooden spoon a chef is using to mix pancake batter, rather than the entire counter. This fine-grained information is called a local representation.The researchers incorporate an additional component into their framework to mitigate misalignments that occur between narration and video. Perhaps the chef talks about cooking the pancake first and performs the action later.To develop a more realistic solution, the researchers focused on uncut videos that are several minutes long. In contrast, most AI techniques train using few-second clips that someone trimmed to show only one action.A new benchmarkBut when they came to evaluate their approach, the researchers couldn’t find an effective benchmark for testing a model on these longer, uncut videos — so they created one.To build their benchmark dataset, the researchers devised a new annotation technique that works well for identifying multistep actions. They had users mark the intersection of objects, like the point where a knife edge cuts a tomato, rather than drawing a box around important objects.“This is more clearly defined and speeds up the annotation process, which reduces the human labor and cost,” Chen says.Plus, having multiple people do point annotation on the same video can better capture actions that occur over time, like the flow of milk being poured. All annotators won’t mark the exact same point in the flow of liquid.When they used this benchmark to test their approach, the researchers found that it was more accurate at pinpointing actions than other AI techniques.Their method was also better at focusing on human-object interactions. For instance, if the action is “serving a pancake,” many other approaches might focus only on key objects, like a stack of pancakes sitting on a counter. Instead, their method focuses on the actual moment when the chef flips a pancake onto a plate.Next, the researchers plan to enhance their approach so models can automatically detect when text and narration are not aligned, and switch focus from one modality to the other. They also want to extend their framework to audio data, since there are usually strong correlations between actions and the sounds objects make.“AI research has made incredible progress towards creating models like ChatGPT that understand images. But our progress on understanding video is far behind. This work represents a significant step forward in that direction,” says Kate Saenko, a professor in the Department of Computer Science at Boston University who was not involved with this work.This research is funded, in part, by the MIT-IBM Watson AI Lab. More

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      A community collaboration for progress

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      While decades of discriminatory policies and practices continue to fuel the affordable housing crisis in the United States, less than three miles from the MIT campus exists a beacon of innovation and community empowerment.“We are very proud to continue MIT’s long-standing partnership with Camfield Estates,” says Catherine D’Ignazio, associate professor of urban science and planning. “Camfield has long been an incubator of creative ideas focused on uplifting their community.”D’Ignazio co-leads a research team focused on housing as part of the MIT Initiative for Combatting Systemic Racism (ICSR) led by the Institute for Data, Systems, and Society (IDSS). The group researches the uneven impacts of data, AI, and algorithmic systems on housing in the United States, as well as ways that these same tools could be used to address racial disparities. The Camfield Tenant Association is a research partner providing insight into the issue and relevant data, as well as opportunities for MIT researchers to solve real challenges and make a local impact.

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      MIT Initiative on Combatting Systemic Racism – Housing Video: MIT Sociotechnical Systems Research Center

      Formerly known as “Camfield Gardens,” the 102-unit housing development in Roxbury, Massachusetts, was among the pioneering sites in the 1990s to engage in the U.S. Department of Housing and Urban Development’s (HUD) program aimed at revitalizing disrepaired public housing across the country. This also served as the catalyst for their collaboration with MIT, which began in the early 2000s.“The program gave Camfield the money and energy to tear everything on the site down and build it back up anew, in addition to allowing them to buy the property from the city for $1 and take full ownership of the site,” explains Nolen Scruggs, a master’s student in the MIT Department of Urban Studies and Planning (DUSP) who has worked with Camfield over the past few years as part of ICSR’s housing vertical team. “At the time, MIT graduate students helped start a ‘digital divide’ bridge gap program that later evolved into the tech lab that is still there today, continuing to enable residents to learn computer skills and things they might need to get a hand up.”Because of that early collaboration, Camfield Estates reached out to MIT in 2022 to start a new chapter of collaboration with students. Scruggs spent a few months building a team of students from Harvard University, Wentworth Institute of Technology, and MIT to work on a housing design project meant to help the Camfield Tenants Association prepare for their looming redevelopment needs.“One of the things that’s been really important to the work of the ICSR housing vertical is historical context,” says Peko Hosoi, a professor of mechanical engineering and mathematics who co-leads the ICSR Housing vertical with D’Ignazio. “We didn’t get to the place we are right now with housing in an instant. There’s a lot of things that have happened in the U.S. like redlining, predatory lending, and different ways of investing in infrastructure that add important contexts.”“Quantitative methods are a great way to look across macroscale phenomena, but our team recognizes and values qualitative and participatory methods as well, to get a more grounded picture of what community needs really are and what kinds of innovations can bubble up from communities themselves,” D’Ignazio adds. “This is where the partnership with Camfield Estates comes in, which Nolen has been leading.”Finding creative solutionsBefore coming to MIT, Scruggs, a proud New Yorker, worked on housing issues while interning for his local congressperson, House Minority Leader Hakeem Jeffries. He called residents to discuss their housing concerns, learning about the affordability issues that were making it hard for lower- and middle-income families to find places to live.“Having this behind-the-scenes experience set the stage for my involvement in Camfield,” Scruggs says, recalling his start at Camfield conducting participatory action research, meeting with Camfield seniors to discuss and capture their concerns.Scruggs says the biggest issue they have been trying to tackle with Camfield is twofold: creating more space for new residents while also helping current residents achieve their end goal of homeownership.“This speaks to some of the larger issues our group at ICSR is working on in terms of housing affordability,” he says. “With Camfield it is looking at where can people with Section 8 vouchers move, what limits do they have, and what barriers do they face — whether it’s through big tech systems, or individual preferences coming from landlords.”Scruggs adds, “The discrimination those people face while trying to find a house, lock it down, talk to a bank, etc. — it can be very, very difficult and discouraging.” Scruggs says one attempt to combat this issue would be through hiring a caseworker to assist people through the process — one of many ideas that came from a Camfield collaboration with the FHLBank Affordable Housing Development Competition.As part of the competition, the goal for Scruggs’s team was to help Camfield tenants understand all of their options and their potential trade-offs, so that in the end they can make informed decisions about what they want to do with their space.“So often redevelopment schemes don’t ensure people can come back.” Scruggs says. “There are specific design proposals being made to ensure that the structure of people’s lifestyles wouldn’t be disrupted.”Scruggs says that tentative recommendations discussed with tenant association president Paulette Ford include replacing the community center with a high-rise development that would increase the number of units available.“I think they are thinking really creatively about their options,” Hosoi says. “Paulette Ford, and her mother before her, have always referred to Camfield as a ‘hand up,’ with the idea that people come to Camfield to live until they can afford a home of their own locally.”Scruggs’s other partnership with Camfield involves working with MIT undergraduate Amelie Nagle as part of the Undergraduate Research Opportunities Program to create programing that will teach computer design and coding to Camfield community kids — in the very TechLab that goes back to MIT and Camfield’s first collaboration.“Nolen has a real commitment to community-led knowledge production,” says D’Ignazio. “It has been a pleasure to work with him and see how he takes all his urban planning skills (GIS, mapping, urban design, photography, and more) to work in respectful ways that foreground community innovation.”She adds: “We are hopeful that the process will yield some high-quality architectural and planning ideas, and help Camfield take the next step towards realizing their innovative vision.” More

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      From steel engineering to ovarian tumor research

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      Ashutosh Kumar is a classically trained materials engineer. Having grown up with a passion for making things, he has explored steel design and studied stress fractures in alloys.Throughout Kumar’s education, however, he was also drawn to biology and medicine. When he was accepted into an undergraduate metallurgical engineering and materials science program at Indian Institute of Technology (IIT) Bombay, the native of Jamshedpur was very excited — and “a little dissatisfied, since I couldn’t do biology anymore.”Now a PhD candidate and a MathWorks Fellow in MIT’s Department of Materials Science and Engineering, Kumar can merge his wide-ranging interests. He studies the effect of certain bacteria that have been observed encouraging the spread of ovarian cancer and possibly reducing the effectiveness of chemotherapy and immunotherapy.“Some microbes have an affinity toward infecting ovarian cancer cells, which can lead to changes in the cellular structure and reprogramming cells to survive in stressful conditions,” Kumar says. “This means that cells can migrate to different sites and may have a mechanism to develop chemoresistance. This opens an avenue to develop therapies to see if we can start to undo some of these changes.”Kumar’s research combines microbiology, bioengineering, artificial intelligence, big data, and materials science. Using microbiome sequencing and AI, he aims to define microbiome changes that may correlate with poor patient outcomes. Ultimately, his goal is to engineer bacteriophage viruses to reprogram bacteria to work therapeutically.Kumar started inching toward work in the health sciences just months into earning his bachelor’s degree at IIT Bombay.“I realized engineering is so flexible that its applications extend to any field,” he says, adding that he started working with biomaterials “to respect both my degree program and my interests.”“I loved it so much that I decided to go to graduate school,” he adds.Starting his PhD program at MIT, he says, “was a fantastic opportunity to switch gears and work on more interdisciplinary or ‘MIT-type’ work.”Kumar says he and Angela Belcher, the James Mason Crafts Professor of biological engineering and materials science, began discussing the impact of the microbiome on ovarian cancer when he first arrived at MIT.“I shared my enthusiasm about human health and biology, and we started brainstorming,” he says. “We realized that there’s an unmet need to understand a lot of gynecological cancers. Ovarian cancer is an aggressive cancer, which is usually diagnosed when it’s too late and has already spread.”In 2022, Kumar was awarded a MathWorks Fellowship. The fellowships are awarded to School of Engineering graduate students, preferably those who use MATLAB or Simulink — which were developed by the mathematical computer software company MathWorks — in their research. The philanthropic support fueled Kumar’s full transition into health science research.“The work we are doing now was initially not funded by traditional sources, and the MathWorks Fellowship gave us the flexibility to pursue this field,” Kumar says. “It provided me with opportunities to learn new skills and ask questions about this topic. MathWorks gave me a chance to explore my interests and helped me navigate from being a steel engineer to a cancer scientist.”Kumar’s work on the relationship between bacteria and ovarian cancer started with studying which bacteria are incorporated into tumors in mouse models.“We started looking closely at changes in cell structure and how those changes impact cancer progression,” he says, adding that MATLAB image processing helps him and his collaborators track tumor metastasis.The research team also uses RNA sequencing and MATLAB algorithms to construct a taxonomy of the bacteria.“Once we have identified the microbiome composition,” Kumar says, “we want to see how the microbiome changes as cancer progresses and identify changes in, let’s say, patients who develop chemoresistance.”He says recent findings that ovarian cancer may originate in the fallopian tubes are promising because detecting cancer-related biomarkers or lesions before cancer spreads to the ovaries could lead to better prognoses.As he pursues his research, Kumar says he is extremely thankful to Belcher “for believing in me to work on this project.“She trusted me and my passion for making an impact on human health — even though I come from a materials engineering background — and supported me throughout. It was her passion to take on new challenges that made it possible for me to work on this idea. She has been an amazing mentor and motivated me to continue moving forward.”For her part, Belcher is equally enthralled.“It has been amazing to work with Ashutosh on this ovarian cancer microbiome project,” she says. “He has been so passionate and dedicated to looking for less-conventional approaches to solve this debilitating disease. His innovations around looking for very early changes in the microenvironment of this disease could be critical in interception and prevention of ovarian cancer. We started this project with very little preliminary data, so his MathWorks fellowship was critical in the initiation of the project.”Kumar, who has been very active in student government and community-building activities, believes it is very important for students to feel included and at home at their institutions so they can develop in ways outside of academics. He says that his own involvement helps him take time off from work.“Science can never stop, and there will always be something to do,” he says, explaining that he deliberately schedules time off and that social engagement helps him to experience downtime. “Engaging with community members through events on campus or at the dorm helps set a mental boundary with work.”Regarding his unusual route through materials science to cancer research, Kumar regards it as something that occurred organically.“I have observed that life is very dynamic,” he says. “What we think we might do versus what we end up doing is never consistent. Five years back, I had no idea I would be at MIT working with such excellent scientific mentors around me.” More

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      in Data Management & Statistics

      Exploring the mysterious alphabet of sperm whales

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      The allure of whales has stoked human consciousness for millennia, casting these ocean giants as enigmatic residents of the deep seas. From the biblical Leviathan to Herman Melville’s formidable Moby Dick, whales have been central to mythologies and folklore. And while cetology, or whale science, has improved our knowledge of these marine mammals in the past century in particular, studying whales has remained a formidable a challenge.Now, thanks to machine learning, we’re a little closer to understanding these gentle giants. Researchers from the MIT Computer Science and Artificial Intelligence Laboratory (CSAIL) and Project CETI (Cetacean Translation Initiative) recently used algorithms to decode the “sperm whale phonetic alphabet,” revealing sophisticated structures in sperm whale communication akin to human phonetics and communication systems in other animal species. In a new open-access study published in Nature Communications, the research shows that sperm whales codas, or short bursts of clicks that they use to communicate, vary significantly in structure depending on the conversational context, revealing a communication system far more intricate than previously understood. 

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      The Secret Language of Sperm Whales, DecodedVideo: MIT CSAIL

      Nine thousand codas, collected from Eastern Caribbean sperm whale families observed by the Dominica Sperm Whale Project, proved an instrumental starting point in uncovering the creatures’ complex communication system. Alongside the data gold mine, the team used a mix of algorithms for pattern recognition and classification, as well as on-body recording equipment. It turned out that sperm whale communications were indeed not random or simplistic, but rather structured in a complex, combinatorial manner. The researchers identified something of a “sperm whale phonetic alphabet,” where various elements that researchers call  “rhythm,” “tempo,” “rubato,” and “ornamentation” interplay to form a vast array of distinguishable codas. For example, the whales would systematically modulate certain aspects of their codas based on the conversational context, such as smoothly varying the duration of the calls — rubato — or adding extra ornamental clicks. But even more remarkably, they found that the basic building blocks of these codas could be combined in a combinatorial fashion, allowing the whales to construct a vast repertoire of distinct vocalizations.The experiments were conducted using acoustic bio-logging tags (specifically something called “D-tags”) deployed on whales from the Eastern Caribbean clan. These tags captured the intricate details of the whales’ vocal patterns. By developing new visualization and data analysis techniques, the CSAIL researchers found that individual sperm whales could emit various coda patterns in long exchanges, not just repeats of the same coda. These patterns, they say, are nuanced, and include fine-grained variations that other whales also produce and recognize.“We are venturing into the unknown, to decipher the mysteries of sperm whale communication without any pre-existing ground truth data,” says Daniela Rus, CSAIL director and professor of electrical engineering and computer science (EECS) at MIT. “Using machine learning is important for identifying the features of their communications and predicting what they say next. Our findings indicate the presence of structured information content and also challenges the prevailing belief among many linguists that complex communication is unique to humans. This is a step toward showing that other species have levels of communication complexity that have not been identified so far, deeply connected to behavior. Our next steps aim to decipher the meaning behind these communications and explore the societal-level correlations between what is being said and group actions.”Whaling aroundSperm whales have the largest brains among all known animals. This is accompanied by very complex social behaviors between families and cultural groups, necessitating strong communication for coordination, especially in pressurized environments like deep sea hunting.Whales owe much to Roger Payne, former Project CETI advisor, whale biologist, conservationist, and MacArthur Fellow who was a major figure in elucidating their musical careers. In the noted 1971 Science article “Songs of Humpback Whales,” Payne documented how whales can sing. His work later catalyzed the “Save the Whales” movement, a successful and timely conservation initiative.“Roger’s research highlights the impact science can have on society. His finding that whales sing led to the marine mammal protection act and helped save several whale species from extinction. This interdisciplinary research now brings us one step closer to knowing what sperm whales are saying,” says David Gruber, lead and founder of Project CETI and distinguished professor of biology at the City University of New York.Today, CETI’s upcoming research aims to discern whether elements like rhythm, tempo, ornamentation, and rubato carry specific communicative intents, potentially providing insights into the “duality of patterning” — a linguistic phenomenon where simple elements combine to convey complex meanings previously thought unique to human language.Aliens among us“One of the intriguing aspects of our research is that it parallels the hypothetical scenario of contacting alien species. It’s about understanding a species with a completely different environment and communication protocols, where their interactions are distinctly different from human norms,” says Pratyusha Sharma, an MIT PhD student in EECS, CSAIL affiliate, and the study’s lead author. “We’re exploring how to interpret the basic units of meaning in their communication. This isn’t just about teaching animals a subset of human language, but decoding a naturally evolved communication system within their unique biological and environmental constraints. Essentially, our work could lay the groundwork for deciphering how an ‘alien civilization’ might communicate, providing insights into creating algorithms or systems to understand entirely unfamiliar forms of communication.”“Many animal species have repertoires of several distinct signals, but we are only beginning to uncover the extent to which they combine these signals to create new messages,” says Robert Seyfarth, a University of Pennsylvania professor emeritus of psychology who was not involved in the research. “Scientists are particularly interested in whether signal combinations vary according to the social or ecological context in which they are given, and the extent to which signal combinations follow discernible ‘rules’ that are recognized by listeners. The problem is particularly challenging in the case of marine mammals, because scientists usually cannot see their subjects or identify in complete detail the context of communication. Nonetheless, this paper offers new, tantalizing details of call combinations and the rules that underlie them in sperm whales.”Joining Sharma, Rus, and Gruber are two others from MIT, both CSAIL principal investigators and professors in EECS: Jacob Andreas and Antonio Torralba. They join Shane Gero, biology lead at CETI, founder of the Dominica Sperm Whale Project, and scientist-in residence at Carleton University. The paper was funded by Project CETI via Dalio Philanthropies and Ocean X, Sea Grape Foundation, Rosamund Zander/Hansjorg Wyss, and Chris Anderson/Jacqueline Novogratz through The Audacious Project: a collaborative funding initiative housed at TED, with further support from the J.H. and E.V. Wade Fund at MIT. More

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      Fostering research, careers, and community in materials science

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      Gabrielle Wood, a junior at Howard University majoring in chemical engineering, is on a mission to improve the sustainability and life cycles of natural resources and materials. Her work in the Materials Initiative for Comprehensive Research Opportunity (MICRO) program has given her hands-on experience with many different aspects of research, including MATLAB programming, experimental design, data analysis, figure-making, and scientific writing.Wood is also one of 10 undergraduates from 10 universities around the United States to participate in the first MICRO Summit earlier this year. The internship program, developed by the MIT Department of Materials Science and Engineering (DMSE), first launched in fall 2021. Now in its third year, the program continues to grow, providing even more opportunities for non-MIT undergraduate students — including the MICRO Summit and the program’s expansion to include Northwestern University.“I think one of the most valuable aspects of the MICRO program is the ability to do research long term with an experienced professor in materials science and engineering,” says Wood. “My school has limited opportunities for undergraduate research in sustainable polymers, so the MICRO program allowed me to gain valuable experience in this field, which I would not otherwise have.”Like Wood, Griheydi Garcia, a senior chemistry major at Manhattan College, values the exposure to materials science, especially since she is not able to learn as much about it at her home institution.“I learned a lot about crystallography and defects in materials through the MICRO curriculum, especially through videos,” says Garcia. “The research itself is very valuable, as well, because we get to apply what we’ve learned through the videos in the research we do remotely.”Expanding research opportunitiesFrom the beginning, the MICRO program was designed as a fully remote, rigorous education and mentoring program targeted toward students from underserved backgrounds interested in pursuing graduate school in materials science or related fields. Interns are matched with faculty to work on their specific research interests.Jessica Sandland ’99, PhD ’05, principal lecturer in DMSE and co-founder of MICRO, says that research projects for the interns are designed to be work that they can do remotely, such as developing a machine-learning algorithm or a data analysis approach.“It’s important to note that it’s not just about what the program and faculty are bringing to the student interns,” says Sandland, a member of the MIT Digital Learning Lab, a joint program between MIT Open Learning and the Institute’s academic departments. “The students are doing real research and work, and creating things of real value. It’s very much an exchange.”Cécile Chazot PhD ’22, now an assistant professor of materials science and engineering at Northwestern University, had helped to establish MICRO at MIT from the very beginning. Once at Northwestern, she quickly realized that expanding MICRO to Northwestern would offer even more research opportunities to interns than by relying on MIT alone — leveraging the university’s strong materials science and engineering department, as well as offering resources for biomaterials research through Northwestern’s medical school. The program received funding from 3M and officially launched at Northwestern in fall 2023. Approximately half of the MICRO interns are now in the program with MIT and half are with Northwestern. Wood and Garcia both participate in the program via Northwestern.“By expanding to another school, we’ve been able to have interns work with a much broader range of research projects,” says Chazot. “It has become easier for us to place students with faculty and research that match their interests.”Building communityThe MICRO program received a Higher Education Innovation grant from the Abdul Latif Jameel World Education Lab, part of MIT Open Learning, to develop an in-person summit. In January 2024, interns visited MIT for three days of presentations, workshops, and campus tours — including a tour of the MIT.nano building — as well as various community-building activities.“A big part of MICRO is the community,” says Chazot. “A highlight of the summit was just seeing the students come together.”The summit also included panel discussions that allowed interns to gain insights and advice from graduate students and professionals. The graduate panel discussion included MIT graduate students Sam Figueroa (mechanical engineering), Isabella Caruso (DMSE), and Eliana Feygin (DMSE). The career panel was led by Chazot and included Jatin Patil PhD ’23, head of product at SiTration; Maureen Reitman ’90, ScD ’93, group vice president and principal engineer at Exponent; Lucas Caretta PhD ’19, assistant professor of engineering at Brown University; Raquel D’Oyen ’90, who holds a PhD from Northwestern University and is a senior engineer at Raytheon; and Ashley Kaiser MS ’19, PhD ’21, senior process engineer at 6K.Students also had an opportunity to share their work with each other through research presentations. Their presentations covered a wide range of topics, including: developing a computer program to calculate solubility parameters for polymers used in textile manufacturing; performing a life-cycle analysis of a photonic chip and evaluating its environmental impact in comparison to a standard silicon microchip; and applying machine learning algorithms to scanning transmission electron microscopy images of CrSBr, a two-dimensional magnetic material. “The summit was wonderful and the best academic experience I have had as a first-year college student,” says MICRO intern Gabriella La Cour, who is pursuing a major in chemistry and dual degree biomedical engineering at Spelman College and participates in MICRO through MIT. “I got to meet so many students who were all in grades above me … and I learned a little about how to navigate college as an upperclassman.” “I actually have an extremely close friendship with one of the students, and we keep in touch regularly,” adds La Cour. “Professor Chazot gave valuable advice about applications and recommendation letters that will be useful when I apply to REUs [Research Experiences for Undergraduates] and graduate schools.”Looking to the future, MICRO organizers hope to continue to grow the program’s reach.“We would love to see other schools taking on this model,” says Sandland. “There are a lot of opportunities out there. The more departments, research groups, and mentors that get involved with this program, the more impact it can have.” More